2009
DOI: 10.1097/aci.0b013e328330634f
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Asthma and pregnancy: emerging evidence of epigenetic interactions in utero

Abstract: New studies reinforce the importance of in-utero exposures (including dietary nutrients, microbial products, cigarette smoking, and certain maternal mediations) in fetal immune development and in programming the susceptibility to asthma and allergic disease.

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Cited by 134 publications
(92 citation statements)
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“…New avenues of research include microbial influences on epigenetic interactions in utero and their potential effect on developmental immune programming through alterations in fetal DNA through altered histone methylation, histone acetylation, and chromatin structure (107). For example, bacterial infections have already been shown to promote DNA hypermethylation (108).…”
Section: Discussionmentioning
confidence: 99%
“…New avenues of research include microbial influences on epigenetic interactions in utero and their potential effect on developmental immune programming through alterations in fetal DNA through altered histone methylation, histone acetylation, and chromatin structure (107). For example, bacterial infections have already been shown to promote DNA hypermethylation (108).…”
Section: Discussionmentioning
confidence: 99%
“…Differences in neonatal immune function of children who go on to develop allergic disease suggest that factors driving this rise in disease are likely to begin to exert their effects in utero (reviewed in [29]). While these changes are environmental (and cannot be explained by genetic changes in this time-frame), this may be the result of effects in both the exogenous and the endogenous environment in pregnancy.…”
Section: Discussionmentioning
confidence: 99%
“…Here we propose that variations in maternal of Th1/Th2 modulation that are conferred by her allergic propensity may influence the fetus similarly. There is emerging evidence of how in utero exposures can modify fetal gene expression through heritable epigenetic effects, which can be amplified across generations (also reviewed in [29]). Thus, it is important to consider the possibility that 'allergy may beget more allergy' with subsequent generations.…”
Section: Discussionmentioning
confidence: 99%
“…The impact of such chemical intoxication is not restricted to the human body development but goes beyond that, affecting the emotional, mental functioning of the organism. Maternal smoking during pregnancy is a risk for abortion (Castles, Adams, Melvin, Kelsch, & Boulton, 1999), preterm delivery (Castles et al, 1999;Kaddar et al, 2009;Shah & Bracken, 2000), respiratory disease (Cook & Strachan, 1999), immune system difficulties such as asthma and allergies (Prescott & Clifton, 2009), and cancer later in life (Doherty, Grabowski, Hoffman, Ng, & Zelikoff, 2009), alterations to the development and function of the placenta (Einarson & Riordan, 2009), delayed psychomotor and mental developmental scores as measured by the Bayley Scales of Infant Development (Kiechl-Kohlendorfer et al, 2010), may negatively impact a child's future speech and language development (Benasich & Tallal, 2002;Kable et al, 2009;Molfese, 2000), is responsible for physical aggression during early childhood (Huijbregts, Seguin, Zoccolillo, Boivin, & Tremblay, 2007;2008). Sudden Infant Death Syndrome (SIDS) is connected with parental smoking (Flemming & Blair, 2015).…”
Section: Maternal Smoke and Other Toxic Storiesmentioning
confidence: 99%