Asthma and sensitization in a community with low indoor allergen levels and low pet-keeping frequency

Al-Mousawi, M.; Lovel, Hermione; Behbehani, Nasser; Arifhodžić, Nermina; Woodcock, Ashley; Čustović, Adnan

doi:10.1016/j.jaci.2004.09.005

Cited by 77 publications

(74 citation statements)

References 35 publications

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“…A cross-sectional study from Kuwait, where pet ownership was even less common, found a positive association between cat ownership and sensitization to cat. 9 These studies and findings from the European Community Health Survey suggest that the community prevalence of cat ownership might influence the likelihood of the pet protective effect. 28 In communities with low cat ownership, non-cat owners at high risk for atopy, in contrast to cat owners, might not be exposed to sufficient cat allergen to experience an allergic response.…”

Section: Discussionmentioning

confidence: 94%

Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort

Perzanowski¹,

Chew²,

Divjan³

et al. 2008

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 94%

Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort

Perzanowski¹,

Chew²,

Divjan³

et al. 2008

Journal of Allergy and Clinical Immunology

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“…Therefore, sensitization to C. herbarum and A. alternata is an important risk factor for severe asthma in these countries (2). Quite unexpectedly, sensitization to the two molds is also the major risk factor for developing asthma in countries with a desert climate, such as Saudi Arabia and Kuwait (32,33). The case histories of the patients tested showed no correlation between RAST classes, pattern of IgE reactivity, and the patients' symptoms.…”

Section: Discussionmentioning

confidence: 96%

NADP-dependent Mannitol Dehydrogenase, a Major Allergen of Cladosporium herbarum

Simon-Nobbe

Denk

Schneider

et al. 2006

Journal of Biological Chemistry

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Cladosporium herbarum is an important allergenic fungal species that has been reported to cause allergic diseases in nearly all climatic zones. 5-30% of the allergic population displays IgE antibodies against molds. Sensitization to Cladosporium has often been associated with severe asthma and less frequently with chronic urticaria and atopic eczema. However, no dominant major allergen of this species has been found so far. We present cloning, production, and characterization of NADP-dependent mannitol dehydrogenase of C. herbarum (Cla h 8) and show that this protein is a major allergen that is recognized by IgE antibodies of ϳ57% of all Cladosporium allergic patients. This is the highest percentage of patients reacting with any Cladosporium allergen characterized so far. Cla h 8 was purified to homogeneity by standard chromatographic methods, and both N-terminal and internal amino acid sequences of protein fragments were determined. Enzymatic analysis of the purified natural protein revealed that this allergen represents a NADP-dependent mannitol dehydrogenase that interconverts mannitol and D-fructose. It is a soluble, non-glycosylated cytoplasmic protein. Two-dimensional protein analysis indicated that mannitol dehydrogenase is present as a single isoform. The cDNA encoding Cla h 8 was cloned from a -ZAP library constructed from hyphae and spores. The recombinant non-fusion protein was expressed in Escherichia coli and purified to homogeneity. Its immunological and biochemical identity with the natural protein was shown by enzyme activity tests, CD spectroscopy, IgE immunoblots with sera of patients, and by skin prick testing of Cladosporium allergic patients. This protein therefore is a new major allergen of C. herbarum.

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“…AL-MOUSAWI et al [27] pointed out that the prevalence of dog ownership was extremely low in the study population (1.5%), and so were the dog allergen levels in the children's home. Therefore, the result may not be suitable for generalisation to the communities where the prevalence of dog ownership is seven times higher.…”

mentioning

confidence: 84%

Dog ownership and contact during childhood and later allergy development

Cm¹,

Morgenstern²,

Bischof³

et al. 2008

Eur Respir J

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The effect of dog ownership during childhood on the development of allergy has been investigated in few studies with conflicting results. The association between dog contact and indoor endotoxin exposure during infancy and the development of allergic sensitisation and atopic disease up to age 6 yrs was investigated.Two ongoing birth cohorts, the German Infant Nutrition Intervention Programme (GINI; n51,962) and the Influences of Lifestyle Related Factors on the Human Immune System and Development of Allergies in Children (LISA; n51,193), were analysed. In both studies, information on children's contact with dogs and their allergic symptoms and doctor-diagnosed allergic disease were collected during follow-up using questionnaires. Specific immunoglobulin E to common aeroallergens was measured at age 6 yrs. House dust samples were collected at age 3 months and the amount of endotoxin was determined.Dog ownership in early childhood was associated with a significantly lower rate of mixed pollen and inhalant sensitisation but not with dog sensitisation or allergic symptoms and diseases up to age 6 yrs. Regular contact with dogs, without ownership, during childhood was not associated with those health outcomes. No associations were found between house dust endotoxin exposure during infancy and sensitisation outcomes.In conclusion, dog ownership in early childhood protects against the development of inhalant sensitisation and this effect cannot be attributed to the simultaneous exposure to endotoxin.

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Asthma and sensitization in a community with low indoor allergen levels and low pet-keeping frequency

Cited by 77 publications

References 35 publications

Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort

Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort

NADP-dependent Mannitol Dehydrogenase, a Major Allergen of Cladosporium herbarum

Dog ownership and contact during childhood and later allergy development

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