Asthma as aetiology of bronchiectasis in Finland

Mäntylä, Jarkko; Mazur, Witold; Törölä, Tanja; Bergman, Paula; Saarinen, Tuure; Kauppi, Paula

doi:10.1016/j.rmed.2019.04.022

Cited by 20 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To address this question, we retrospectively analyzed 234 hospitalized patients aged ≥18 years with non-cystic fibrosis bronchiectasis in the past 8 years in West China hospital. Asthma was considered as the etiology driver to bronchiectasis if it was diagnosed earlier than bronchiectasis, consistent with the definition in the study by Jarkko Mantyla [2]. Our results showed that: among the 32 patients (14%) with bronchiectasis complicated with asthma, 15 patients (6%) were caused by asthma, with higher BMI and worse lung ventilation function (FEV1%, FEV1/FVC, MMEF%) ( Table 1).…”

Section: To the Editorsupporting

confidence: 87%

“…Fewer researches have been performed on the coexistence of bronchiectasis and asthma due to the neglects and not enough attentions [1]. Recently, Jarkko Mantyla has investigated the characteristics and outcomes of patients with bronchiectasis in Finland, of which he has specifically addressed bronchiectasis caused by asthma [2]. He found that clinical parameters including body mass index (BMI), highresolution computed tomography (HRCT) ≥ 4 affected lobes, and the number of hospitalization due to exacerbations were higher in the 25 cases (26%) with bronchiectasis caused by asthma compared to those in the 70 patients with bronchiectasis caused by miscellaneous aetiologies.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Asthma-associated bronchiectasis: More attention needed!

Liu¹,

Huang²,

Yang

et al. 2020

Respiratory Medicine

View full text Add to dashboard Cite

Section: To the Editorsupporting

confidence: 87%

Section: To the Editormentioning

confidence: 99%

Asthma-associated bronchiectasis: More attention needed!

Liu¹,

Huang²,

Yang

et al. 2020

Respiratory Medicine

View full text Add to dashboard Cite

“…First, it may support the perspective that bronchiectasis is a consequence of asthma and, therefore, needs time to develop. [ 28 ] Also, it may indicate that the clinical features of bronchiectasis in patients with asthma may be overshadowed by the symptoms of asthma.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of asthma with comorbid bronchiectasis

Zhang¹,

Xiong²,

Wu³

et al. 2021

Medicine

View full text Add to dashboard Cite

Background: This meta-analysis aimed to systematically estimate the prevalence of comorbid bronchiectasis in patients with asthma and to summarize its clinical impact. Methods: Embase, PubMed, and Cochrane Library electronic databases were searched to identify relevant studies published from inception until March 2020. Study Selection: Studies were included if bronchiectasis was identified by high-resolution computed tomography. Outcomes included the prevalence of bronchiectasis and its association with demographic characteristics and indicators of asthma severity, including results of lung function tests and the number of exacerbations. Results: Five observational studies with 839 patients were included. Overall, the mean prevalence of bronchiectasis in patients with asthma was 36.6% (307/839). Patients with comorbid bronchiectasis had lower forced expiratory volume in 1 second (FEV 1 )/forced vital capacity (FVC) (MD: −2.71; 95% CI: −3.72 to −1.69) and more frequent exacerbations (MD: 0.68; 95% CI: 0.03 to 1.33) than those with asthma alone, and there was no significant difference of sex, duration of asthma and serum levels of immunoglobulin(Ig)Es between asthmatic patients with or without bronchiectasis. Conclusion: The presence of bronchiectasis in patients with asthma was associated with greater asthma severity. There are important therapeutic implications of identifying bronchiectasis in asthmatic patients.

show abstract

“…Only those over 18 years of age and with non-cystic brosis BE were recruited. Details of this cohort have been reported previously [11].…”

Section: Methodsmentioning

confidence: 99%

Poor Physical Capacity in Bronchiectasis Patients Is Correlated with Poor Quality of Life

Mäntylä¹,

Törölä

Mazur

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

BackgroundTo study the risk factors associated with quality of life (QoL) in a cohort of Finnish non-cystic fibrosis bronchiectasis (BE) patients. We aimed to evaluate which of the clinical characteristics were risk factors for poor quality of life, how patients with frequent exacerbations differed from those with only few exacerbations and if QoL symptom domains were correlated with dyspnoea or severity of BE.MethodsA cross-sectional study and part of the EMBARC study including questionnaire data and medical record data. Study participants were recruited between August 2016 and March 2018 from three different pulmonary clinics in Helsinki University Central Hospital (HUH) catchment area, Finland. The study included 95 adult patients with (mean age was 69 (SD± 13) years).A Finnish translation of the disease-specific quality of life-bronchiectasis (QoL-B) questionnaire was applied, and scores in the lowest quarter (25%) of the scale were considered to indicate poor QoL. The bronchiectasis severity index (BSI) and FACED (including FEV1, age, pulmonary bacterial colonization, affected lobes and dyspnoea) score were used. The severity of dyspnoea was examined using the modified Medical Research Council (mMRC) dyspnoea scale.ResultsAlmost all (82%) presented with chronic sputum production and exacerbations, with a median rate of 1.7 (SD ±1.6). Exacerbations (OR 1.7, p < 0.01), frequent exacerbations (OR 4.9, p < 0.01), high BSI score (OR 1.3, p < 0.01) and extensive disease (OR 3.7, p = 0.05) were predictive of poor QoL. Frequent exacerbations were associated with bronchial bacterial colonisation, low forced expiratory volume in one second (FEV1) and radiological disease severity. Based on the BSI, 34.1% of our cohort had severe disease, whereas 11.6% were classified as severe according to the FACED score. The mMRC dyspnoea score (r = -0.57) and BSI (r = -0.60) were negatively correlated with physical domain in QoL-B questionnaire. ConclusionFrequent exacerbations, radiological disease severity and high BSI score were predictive of poor QoL. Reduced physical capacity was correlated with dyspnoea and severity of disease. Interventions to reduce bacterial colonisation and to maintain physical functioning should be used to minimize exacerbations and to improve quality of life in BE patients.Study registrationUniversity of Helsinki, faculty of medicine; 148/16.08.2017

show abstract

Asthma as aetiology of bronchiectasis in Finland

Cited by 20 publications

References 23 publications

Asthma-associated bronchiectasis: More attention needed!

Asthma-associated bronchiectasis: More attention needed!

Clinical features of asthma with comorbid bronchiectasis

Poor Physical Capacity in Bronchiectasis Patients Is Correlated with Poor Quality of Life

Contact Info

Product

Resources

About