Asthma control and COPD symptom burden in patients using fixed-dose combination inhalers (SPRINT study)

Roche, Nicolás; Plaza, Vicente; Backer, Vibeke; Palen, Job van der; Cerveri, Isa; Gonzalez, Chelo; Safioti, Guilherme; Scheepstra, Irma; Patino, Oliver; Singh, Dave

doi:10.1038/s41533-019-0159-1

Cited by 26 publications

(22 citation statements)

References 34 publications

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“…While it seems to have been taken for granted that poor adherence is one common reason behind not-controlled asthma, previous studies in this field have usually been cross-sectional or short-term follow-ups and no long-term studies have been conducted [10][11][12][13][14][15][16][17] . These crosssectional studies mostly included patients having asthma diagnosis but the information on age of asthma onset, diagnostic criteria or duration of asthma were often lacking [10][11][12]14,[16][17][18] loss.…”

Section: Decline In Lung Functionmentioning

confidence: 99%

“…In these studies, mean adherence to ICS was 52% and 69%, respectively. Previous studies assessing asthma control and adherence have been either crosssectional or with short follow-ups [10][11][12][13][14][15][16][17][18] . In addition, the evaluation of adherence and asthma control has mostly been questionnaire-based and information concerning diagnostic criteria, duration and age of onset of asthma are often missing, potentially influencing the results 4,13,15 .…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies assessing asthma control and adherence have been either cross-sectional or with short follow-up [ 10 – 18 ]. In addition, the evaluation of adherence and asthma control has mostly been questionnaire-based and information concerning diagnostic criteria, duration and age of onset of asthma are often missing, potentially influencing the results [ 4 , 13 , 15 ]. Poor asthma control has been associated with higher risk of exacerbations, lower quality of life and increased healthcare use [ 2 , 4 , 10 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma

et al. 2021

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BackgroundIn short-term studies, poor adherence to inhaled corticosteroids (ICS) has been associated with worse asthma control, but the association of long-term adherence and disease control remains unclear.ObjectiveTo assess the relationship between 12-year adherence to ICS and asthma control in patients with adult-onset asthma.MethodsAs part of the Seinäjoki Adult Asthma Study, 181 patients with clinically confirmed new-onset adult asthma and regular ICS medication were followed-up for 12 years. Adherence (%) to ICS was assessed individually ((µg dispensed/µg prescribed)×100) during the follow-up. Asthma control was evaluated after 12 years of treatment according to the Global Initiative for Asthma 2010 guideline.ResultsAsthma was controlled in 31% and not controlled (partly controlled or uncontrolled) in 69% of the patients. Patients with not-controlled asthma were more often male, older, nonatopic and used higher doses of ICS than those with controlled disease. The mean±sd 12-year adherence to ICS was 63±38% in patients with controlled asthma and 76±40% in patients with not-controlled disease (p=0.042). Among patients with not-controlled asthma, those with lower 12-year adherence (<80%) had more rapid decline in forced expiratory volume in 1 s (−47 mL·year−1) compared to patients with better adherence (≥80%) (−40 mL·year−1) (p=0.024). In contrast, this relationship was not seen in patients with controlled asthma.ConclusionsIn adult-onset asthma, patients with not-controlled disease showed better 12-year adherence to ICS treatment than those with controlled asthma. In not-controlled disease, adherence <80% was associated with more rapid lung function decline, underscoring the importance of early recognition of such patients in routine clinical practice.

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Section: Decline In Lung Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma

et al. 2021

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“…The use of telephones as a tool for the application and supervision of an exercise training program for patients with moderate to severe COPD in a home environment, has been used by different studies with good clinical and compliance results [ 44 ]. However, in a recent meta-analysis, the evidence for effectiveness in physical function was inconsistent across studies and the combined effect size was not significant with notable variation in the outcome measures used between trials [ 45 ]. Most PR studies in COPD that compare home versus hospital-based programs have analyzed outcomes in quality of life or exercise capacity (6MWT) [ 21 , 43 , 46 ], but few studies have focused on the effect of home RP interventions on muscular strength or functional performance of lower limbs.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Non-Presential Individualized Exercise Training PrOgram(NIETO) in Lower Limb Physical Performance in Advanced COPD

Sánchez-Nieto

Fernández-Muñoz

Carrillo-Alcaraz

et al. 2021

JCM

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Muscle training, a component of pulmonary rehabilitation (PR), improves the physical performance of patients with chronic obstructive pulmonary disease (COPD). Despite the existing evidence, the traditional center-based PR model is applied to a small percentage of patients and presents numerous problems of accessibility, adherence, and costs. This study present a home model of simple muscle training, non-presential, monitored by telephone and individualized, according to the severity of the COPD. In addition, to evaluate the results, simple tests associated with the physical performance of the lower limbs, previously validated in COPD, have been used, such as the four-meter walk, speed test (4MGS) and the five-repetition test sitting and standing (5STS). The objective was to evaluate whether the Individualized Non-Presential Exercise Training PrOgram (NIETO) induces improvements in the 4MGS, 5STS and quadriceps muscle strength (QMS) tests in outpatients with advanced COPD (FEV1 ≤ 50%). After one year, the QMS was significantly higher in the intervention group (IG) than in the control group (CG) (2.44 ± 4.07 vs. 0.05 ± 4.26 kg; p = 0.009). The 4MGS and 5STS tests were significantly shorter in IG than in CG (−0.39 ± 0.86 vs. 0.37 ± 0.96 s; p = 0.001) and (−1.55 ± 2.83 vs. 0.60 ± 2.06 s; p = 0.001), respectively. A home model of simple muscle training monitored by telephone such as NIETO, can improve 4MGS, 5STS, and quadriceps strength tests in outpatients with advanced COPD.

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“…It can complicate the diagnosis and the management of asthma. The symptom of co-morbid conditions may be similar to those associated with poor asthma control which can lead to misdiagnosis and under treatment or over treatment [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Self-care practice and associated factors among adult asthmatic patients on follow-up care at Northwest Amhara referral hospitals, Northwest Ethiopia 2020

2021

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Background Self-care practice of asthma is the strategy for asthma symptom control and future reduction of exacerbation, but it is poorly implemented in clinical settings due to the patients, professionals, and organizational related factors. Therefore, the study aimed to assess the self-care practice and associated factors among adult asthmatic patients at Northwest Amhara referral hospitals. Methods Institution-based cross-sectional study was conducted among asthmatic patients on follow-up care at Northwest Amhara Regional State referral hospitals from February 1st, 2020 to March 30, 2020. Data were collected through an interviewer-administered technique. Asthma self-care practice tool was used to measure the outcome. Data were entered into EPI info version 7 and exported to SPSS version 22 for analysis. A binary logistic regression analysis was used. In multivariable logistic regression analysis, those independent variables having p value < 0.05 were considered as statistically significant with poor self-care practice of asthma. Results A total of 470 participants enrolled in the study with a response rate of 100%. The proportion of good self-care practice among asthmatic patients was found to be 42.3%. The study revealed that; age group ≥ 55 years, having a co-morbid illness and borderline anxiety, having no social support, and drinking alcohol were significantly associated with poor asthma self-care practice. Conclusions Poor-self care practice in this study was high. Efforts need to be implemented for asthmatic patients with older age, having co-morbid illness and borderline anxiety, having no social support, and drinking alcohol.

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Asthma control and COPD symptom burden in patients using fixed-dose combination inhalers (SPRINT study)

Cited by 26 publications

References 34 publications

Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma

Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma

Effectiveness of Non-Presential Individualized Exercise Training PrOgram(NIETO) in Lower Limb Physical Performance in Advanced COPD

Self-care practice and associated factors among adult asthmatic patients on follow-up care at Northwest Amhara referral hospitals, Northwest Ethiopia 2020

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