Asthma Drugs Counter-regulate interleukin-8 Release Stimulated by Sodium Sulfite in an A549 Cell Line

Yang, Yu‐Shih; Hsu, Jeng-Yuan; Fu, Lin-Shien; Hsu, Fei‐Ting; Chu, Jao-Jia

doi:10.1080/02770900802628508

Cited by 14 publications

(10 citation statements)

References 51 publications

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“…IL-8 is a chemical signal involved in neutrophil recruitment and activation. IL-8 release was inhibited by a selection of asthma drugs (Yang et al, 2009). Sulfite oxidation by a mammalian peroxidase-hydrogen peroxide system, resulting in the highly reactive sulfate radical ), has been shown for the first time in an experiment using human myeloperoxidase and human neutrophils and (bi)sulfite anions at 20-100 μM (Ranguelova et al, 2012).…”

Section: Short-term Respiratory Effectsmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Section: Short-term Respiratory Effectsmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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“…Therefore, it is thought that the IL-8 may be upregulated by proinflammatory compounds and oxidants. Therefore, we chose chlorobenzene [31], sodium sulfite [32], and sphingosine-1-phosphate [33] as proinflammatory compounds, and paraquat [34] as an oxidant (Table 3). …”

Section: Resultsmentioning

confidence: 99%

A Novel Approach for a Toxicity Prediction Model of Environmental Pollutants by Using a Quantitative Structure-Activity Relationship Method Based on Toxicogenomics

et al. 2011

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The development of automobile emission reduction technologies has decreased dramatically the particle concentration in emissions; however, there is a possibility that unexpected harmful chemicals are formed in emissions due to new technologies and fuels. Therefore, we attempted to develop new and efficient toxicity prediction models for the myriad environmental pollutants including those in automobile emissions. We chose 54 compounds related to engine exhaust and, by use of the DNA microarray, examined their effect on gene expression in human lung cells. We focused on IL-8 as a proinflammatory cytokine and developed a prediction model with quantitative structure-activity relationship (QSAR) for the IL-8 gene expression by using an in silico system. Our results demonstrate that this model showed high accuracy in predicting upregulation of the IL-8 gene. These results suggest that the prediction model with QSAR based on the gene expression from toxicogenomics may have great potential in predictive toxicology of environmental pollutants.

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“…Mining the literature identified that 2 natural products, wedelolactone [12] and ellagic acid [13] are active in modulating allergic reaction in vitro and/or in vivo. Ellagic acid was recently found to be a potent GPR35 agonist in our laboratory [22].…”

Section: Resultsmentioning

confidence: 99%

“…Natural products have been the single most productive source to identify leads for drug development [9]. Certain phytochemicals including gallic acid [10], caffeic acid [11], wedelolactone [12] and ellagic acid [13] can suppress allergic reaction-related cellular responses in vitro and/or allergic symptoms in vivo, although their molecular mode of action for anti-inflammatory effects are mostly unknown [14,15]. Thus, we hypothesized that these anti-inflammatory natural products may modulate allergic responses via their agonism at the GPR35.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Gallic Acid and Wedelolactone Are G Protein-Coupled Receptor-35 Agonists

Deng

2012

Pharmacology

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G protein-coupled receptor-35 (GPR35) has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Gallic acid and caffeic acids are reported to modulate allergic reactions via unknown mode(s) of action. Here we attempt to elucidate whether both phenolic acids share a common mode of action with the two asthma drugs. Label-free dynamic mass redistribution (DMR) assays showed that both phenolic acids triggered robust DMR signals in HT-29 cells, whose characteristics were similar to that of cromolyn disodium. Both phenolic acids resulted in detectable β-arrestin translocation signals in an engineered U2OS cell line stably expressing a C-terminal-modified GPR35, but with lower efficacy than cromolyn disodium. Antiallergic wedelolactone was found to be a potent β-arrestin-biased GPR35 agonist. These results suggest that certain anti-inflammatory phytochemicals including gallic acid and wedelolactone may modulate inflammatory allergic action via their agonism at GPR35. GPR35 may represent a target for the treatment of allergic disorders including asthma.

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Asthma Drugs Counter-regulate interleukin-8 Release Stimulated by Sodium Sulfite in an A549 Cell Line

Cited by 14 publications

References 51 publications

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A Novel Approach for a Toxicity Prediction Model of Environmental Pollutants by Using a Quantitative Structure-Activity Relationship Method Based on Toxicogenomics

Anti-Inflammatory Gallic Acid and Wedelolactone Are G Protein-Coupled Receptor-35 Agonists

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