Asthma in every fifth child in Oslo, Norway: a 10‐year follow up of a birth cohort study*

Carlsen, Kai‐Håkon; Håland, Geir; Devulapalli, Chandra Sekhar; Munthe‐Kaas, Monica Cheng; Pettersen, Morten; Granum, Berit; Løvik, Martinus; Carlsen, K-H.

doi:10.1111/j.1398-9995.2005.00938.x

Cited by 149 publications

(58 citation statements)

References 31 publications

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“…The prevalence of asthma found in the present study is lower than the prevalence reported in other European countries as Norway, where the prevalence was 11.1% in 10 year-old children (Lødrup Carlsen et al, 2006), Portugal, where the prevalence was 12.9% in 13-year-old children (Falcão et al, 2008), Greece, where the prevalence was 9.0% and 5.0% at 7 and 18 years, respectively (Bacopoulou et al, 2009), or France, where the prevalence among children between 11 and 14 years was 9% (Delmas et al, 2009). Nevertheless, our results are more proximal to the prevalence found in Sweden children (5.9%) from 5-14 years old (Kim et al, 2005), Dutch children (6.5%), who had the same range age than children studied in our study (8-13 years) (Tabak et al, 2006) or One-way ANOVA was used to identify significant differences between children with and without asthma.…”

Section: Discussioncontrasting

confidence: 55%

Fat intake and asthma in Spanish schoolchildren

et al. 2010

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Objectives: To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren. Subjects/Methods: The subjects of this cross-sectional study were 638 Spanish schoolchildren (8-13 years of age). The weight and height of all the subjects were recorded. A questionnaire, completed by the subjects' parents, was used to obtain personal and health information. Current asthma was established when the children had ever had asthma, if they had been diagnosed with asthma by a doctor and if they had been treated with medications at some time in the previous 12 months. Food intake was monitored using a 3-day food record. All foods consumed were converted into energy and nutrients. Results: The energy derived from lipids, saturated fatty acids (SFAs) and myristic and palmitic acids was independently associated with current asthma (Odds Ratio (OR) third tertile 2.85 (1.01-8.07) P ¼ 0.049, 10.00 (0.89-111.97) P ¼ 0.002, 11.21 (1.36-92.24) P ¼ 0.002, 7.58 (1.40-41.03) P ¼ 0.022, respectively), as was the intake of butter (OR third tertile 2.97 (1.01-8.68) P ¼ 0.001). No relationship was seen between this condition and the intake of any other fatty acid, the n-6/n-3 ratio, nor the consumption of margarine, milk products, fish, meat, eggs or vegetable oils. Conclusions: Increased intakes of SFAs, myristic and palmitic acids and butter seem to be related to the risk of current asthma in children.

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Section: Discussioncontrasting

confidence: 55%

Fat intake and asthma in Spanish schoolchildren

et al. 2010

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“…T1D patients were diagnosed according to EURODIAB criteria. 39 Allergic asthma was diagnosed based on having two of the three following criteria in the presence of at least one positive skin prick test against a standard panel of food and inhalant allergens: 38,40 (1) symptoms, (2) medication, (3) a doctor's diagnosis by the age of 10.…”

Section: Methodsmentioning

confidence: 99%

“…Both the asthma cases and the T1D controls and asthma controls were selected from a general Norwegian population-based birth cohort study, the ECA. 38 The control groups used in the T1D and asthma analyses are not totally identical, as the T1D control group included children without a diagnosis of T1D, whereas the asthma control group included children without a diagnosis of allergy or asthma. More than 95% of the cases and controls were of Norwegian ethnicity.…”

Section: Subjectsmentioning

confidence: 99%

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

et al. 2009

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Type 1 diabetes (T1D) and allergic asthma are immune-mediated diseases. Pattern recognition receptors are proteins expressed by cells in the immune system to identify microbial pathogens and endogenous ligands. Toll-like receptors (TLRs) and CD14 are members of this family and could represent a molecular link between microbial infections and immune-mediated diseases. Diverging hypotheses regarding whether there exists a common or inverse genetic etiology behind these immunemediated diseases have been presented. We aimed to test whether there exist common or inverse associations between polymorphisms in the pattern recognition receptors TLR2, TLR4 and CD14 and T1D and allergic asthma. Eighteen single nucleotide polymorphisms (SNPs) were genotyped in TLR2 (2), TLR4 (12) and CD14 (4) in 700 T1D children, 357 nuclear families with T1D children and 796 children from the 'Environment and Childhood Asthma' study. Allele and haplotype frequencies were analyzed in relation to diseases and in addition transmission disequilibrium test analyses were performed in the family material. Both T1D and allergic asthma were significantly associated with the TLR2 rs3804100 T allele and further associated with the haplotype including this SNP, possibly representing a susceptibility locus common for the two diseases. Neither TLR4 nor CD14 were associated with T1D or allergic asthma.

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“…Det er angitt at mellom 1 500 og 3 000 barn pr. år fødes med en eller flere misdannelser (Parelius & Aag, 2008 Norske studier angir at 20-25 % av norske barn har eller har hatt astma ved 10 års alder (Carlsen et al, 2006), men det er et stort spenn i alvorlighet av sykdommen. Man finner ingen geografiske forskjeller i forekomst av astma (Nystad et al, 1997 …”

Section: Faglig Samarbeidunclassified