Asthma in merchant seamen and laboratory workers caused by allergy to castor beans: analysis of allergens

Davison, A. G.; Britton, Mark; Forrester, J. A.; Davies, Robert J.; Hughes, David T.

doi:10.1111/j.1365-2222.1983.tb02637.x

Cited by 26 publications

(9 citation statements)

References 13 publications

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“…sIgE to conalbumin and lysozyme was less frequently found (the sensitivities were 0.6 and 0.4, respectively) 39. sIgE against the highly purified components ricin, ricinus agglutinin and dericinus of castor beans was detected in all three sera that were positive for the complete allergen, including one false-positive result 40. An identical sensitivity of 1.0 was also reported for four subjects for the two enzymes alpha-amylase and lipase from porcine pancreatic extract 17…”

Section: Resultsmentioning

confidence: 63%

Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis

et al. 2019

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ObjectivesTo determine the test performance parameters for the retrievable range of high-molecular-weight (HMW) and low-molecular-weight (LMW) occupational allergens and to evaluate the impact of allergenic components and the implementation of measures for test validation.MethodsA protocol with predefined objectives and inclusion criteria was the basis of an electronic literature search of MEDLINE and EMBASE (time period 1967–2016). The specific inhalation challenge and serial peak flow measurements were the reference standards for the specific IgE (sIgE) test parameters. All of the review procedures were reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses.ResultsSeventy-one studies were selected, and 62 entered meta-analysis. Pooled pairs analysis indicated a sensitivity of 0.74(95% CI 0.66 to 0.80) and specificity of 0.71(95% CI 0.63 to 0.77) for HMW allergens and a sensitivity of 0.28(95% CI 0.18 to 0.40) and specificity of 0.89(95% CI 0.77 to 0.95) for LMW allergens. Component-specific analysis improved the test parameters for some allergens. Test validation was handled heterogeneously among studies.ConclusionsIgE test performance is rather satisfactory for a wide range of HMW allergens with the potential for component-specific approaches, whereas sensitivity for LMW allergens is considerably lower, indicating methodological complications and/or divergent pathomechanisms. A common standard for test validation is needed.

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Section: Resultsmentioning

confidence: 63%

Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis

et al. 2019

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“…Those individuals who had epidemic asthma had specific IgE sensitization to soy bean and were shown to have experienced exposure to high levels of soy bean [70]. Similarly, exposure to castor bean has also been implicated in asthma epidemics [71].…”

Section: Ige‐mediated Allergymentioning

confidence: 99%

Report on the potential allergenicity of genetically modified organisms and their products

Lack

Chapman²,

Kalsheker

et al. 2002

Clin Experimental Allergy

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“…Castor bean allergy has been studied for years by one of us in collaboration with Layton [22][23][24][25] and has been used as a model for the evaluation of in vitro techniques of detection of specific IgE [26,27]. Recently new aspects of castor bean allergy have been investigated [28][29][30]. Our aim was to study the problems of sensitivity to this allergen, using RAST as a complement to skin testing in the diagnosis of clinical allergy.…”

Section: Introductionmentioning

confidence: 99%

Results of skin test and RAST in allergy to a clinically potent allergen (castor bean)

Panzani

Johansson

1986

Clin Experimental Allergy

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Summary In order to investigate once more the usefulness of the RAST procedure in the diagnosis of reaginic hypersensitivity, we studied a series of patients showing a well known sensitivity to castor bean, which is a potent antigen, and compared the results with those given by patients with no clinical allergy to this antigen as confirmed by negative skin testing. The latter group included patients with no contact, a remote contact or a close contact with castor bean. Castor bean allergy seems to be a good model in the testing of human reaginic hypersensitivity. We observed in the castor bean positive group of forty‐one patients a 95% correlation between RAST positivity and skin test positivity with only two negative RAST scores, and in the castor bean negative group of ninety‐four patients, a 97% correlation, with three RAST positive scores. For its specificity and its good sensibility (although lesser than skin testing), RAST can thus be recommended as a diagnostic tool as a complement to skin testing. Moreover, for potent allergens, RAST offers a risk‐free diagnostic alternative.

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Asthma in merchant seamen and laboratory workers caused by allergy to castor beans: analysis of allergens

Cited by 26 publications

References 13 publications

Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis

Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis

Report on the potential allergenicity of genetically modified organisms and their products

Results of skin test and RAST in allergy to a clinically potent allergen (castor bean)

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