Asthma in rural Bangladeshi children

Zaman, Khalequz; Takeuchi, Haruko; Yunus, Muhammad; Arifeen, Shams El; Chowdhury, Hafizur Rahman; Baqui, Abdullah H; Wakai, Susmu; Iwata, Tadahisa

doi:10.1007/s12098-007-0104-0

Cited by 32 publications

(36 citation statements)

References 30 publications

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“…By contrast, the prevalence of current wheezing, diagnosed asthma, and allergic rhinoconjunctivitis in Tibet was 0.8%, 1.1%, and 5.2%, respectively 85. Although asthma prevalence in rural Bangladesh is 16.1%86 and in Pakistan there is a doubling of the prevalence of AR and asthma in ISAAC III as compared with ISAAC I, in a study in urban India the overall prevalence of asthma was 2.38% 87. Prevalence of allergic rhinitis in 5- to 11-year-old children in Vietnam is 34.9%88 and prevalence of allergic rhinitis in patients with asthma is 48.54% (Le Van Khang et al Study of sensitivity, specificity of house dust mite allergen made in Vietnam in diagnosis of asthma.…”

Section: Asthma and Allergic Rhinitis In Asia Pacificmentioning

confidence: 91%

Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008

Pawankar

Bunnag

Khaltaev

et al. 2012

World Allergy Organization Journal

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The prevalence of allergic diseases such as allergic rhinitis (AR) and asthma are markedly increasing to epidemic proportions worldwide as societies adopt Western lifestyles. An estimated 300 million persons worldwide have asthma, about 50% of whom live in developing countries, and about 400 million people suffer from AR. AR has a marked impact on quality of life, socially, at school, and in the workplace and is a huge socioeconomic burden. Thus, there was clearly a need for a global evidence-based guideline not only for managing AR but also highlighting the interactions between the upper and lower airways including diagnosis, epidemiology, common risk factors, management, and prevention. The Allergic Rhinitis and its Impact on Asthma (ARIA) document was first published in 2001 as a state-of-the-art document for the specialist, the general practitioner, and other health care professionals. Subsequent research and increasing knowledge have resulted in the ARIA 2008 update. The present review summarizes the ARIA update with particular emphasis on the current status of AR and asthma in Asia Pacific.

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Section: Asthma and Allergic Rhinitis In Asia Pacificmentioning

confidence: 91%

Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008

Pawankar

Bunnag

Khaltaev

et al. 2012

World Allergy Organization Journal

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“…The ISAAC study demonstrated a high prevalence of asthma in schoolchildren in low-income countries; 55 for example, in Mozambique the prevalence of current asthma was 13.3% in schoolchildren aged 6-7 years 56 and the 1-year prevalence among children aged 5-6 years in Bangladesh was 16.1%. 57 Of the few studies reported in under-5s, the prevalence of asthma in 4-year-old children in Tanzania was found to be 14.0 % and the prevalence of current wheezing during infancy was 13.8%. 58 In Brazil the prevalence of wheeze in 6-59-month-old children was 12.5%, of whom 93% were reported with a medical diagnosis of asthma.…”

Section: Under-diagnosis Of Asthmamentioning

confidence: 95%

“…69 Epidemiological studies suggest that children diagnosed with recurrent pneumonia in infancy are often later diagnosed with asthma. 25,57,71,72 Heffelfinger et al suggested that children diagnosed with recurrent pneumonia according to IMCI-criteria in Haiti, compared with children never diagnosed with pneumonia, were more likely to get an asthma diagnosis later, and asthma should be considered as an alternatiove diagnosis to recurrent pneumonia.…”

Section: Under-diagnosis Of Asthmamentioning

confidence: 99%

Childhood asthma in low income countries: an invisible killer?

Østergaard

Nantanda

Tumwine

et al. 2012

Primary Care Respiratory Journal

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Bacterial pneumonia has hitherto been considered the key cause of the high respiratory morbidity and mortality in children under five years of age (under-5s) in low-income countries, while asthma has not been stated as a significant reason. This paper explores the definitions and concepts of pneumonia and asthma/wheezing/bronchiolitis and examines whether asthma in under-5s may be confused with pneumonia. Over-diagnosing of bacterial pneumonia can be suspected from the limited association between clinical pneumonia and confirmatory test results such as chest x-ray and microbiological findings and poor treatment results using antibiotics. Moreover, children diagnosed with recurrent pneumonia in infancy were often later diagnosed with asthma. Recent studies showed a 10-15% prevalence of preschool asthma in low-income countries, although under-5s with long-term cough and difficulty breathing remain undiagnosed. New studies demonstrate that approximately 50% of acutely admitted under-5s diagnosed with pneumonia according to Integrated Management of Childhood Illnesses could be re-diagnosed with asthma or wheezing when using re-defined diagnostic criteria and treatment. It is hypothesised that untreated asthma may contribute to respiratory mortality since respiratory syncytial virus (RSV) is an important cause of respiratory death in childhood, and asthma in under-5s is often exacerbated by viral infections, including RSV. Furthermore, acute respiratory treatment failures were predominantly seen in under-5s without fever, which suggests the diagnosis of asthma/wheezing rather than bacterial pneumonia. Ultimately, underlying asthma may have contributed to malnutrition and fatal bacterial pneumonia. In conclusion, preschool asthma in low-income countries may be significantly under-diagnosed and misdiagnosed as pneumonia, and may be the cause of much morbidity and mortality.

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“…However, the association between helminth infection and childhood asthma and atopy remains controversial [8]. In the present study, we examined the effects of helminth infections on asthma and atopy among children in Bangladesh, where repeated helminth infections occur and the prevalence of asthma and atopy is increasing [9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children

Hawlader

Noguchi

et al. 2014

Trop.Med.Health

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Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children. A total of 912 children aged 4.5 years (mean = 54.4, range = 53.5–60.8 months) participated in a cross-sectional study nested into a randomized controlled trial in Bangladesh. Ever-asthma, ever-wheezing and current wheezing were identified using the International Study of Asthma and Allergies in Childhood questionnaire. Current helminth infection was defined by the presence of helminth eggs in stools, measured by routine microscopic examination. Repeated Ascaris infection was defined by the presence of anti-Ascaris IgE ≥ 0.70 UA/ml in serum measured by the CAP-FEIA method. Atopy was defined by specific IgE to house dust mite (anti-DP IgE) ≥ 0.70 UA/ml measured by the CAP-FEIA method and/or positive skin prick test (≥ 5 mm). Anti-Ascaris IgE was significantly associated with ever asthma (odds ratio (OR) = 1.86, 95% CI: 1.14–3.04, highest vs. lowest quartile; P for trend 0.016). Anti-Ascaris IgE was also significantly associated with positive anti-DP IgE (OR = 9.89, 95% CI: 6.52–15.00, highest vs. lowest; P for trend < 0.001) and positive skin prick test (OR = 1.69, 95% CI: 1.01–2.81, highest vs. lowest, P for trend 0.076). These findings suggest that repeated Ascaris infection is a risk factor for asthma and atopy in rural Bangladeshi children. Further analysis is required to examine the mechanism of developing asthma and atopy in relation to helminth infection.

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Asthma in rural Bangladeshi children

Abstract: Our results suggest that wheezing is a significant cause of morbidity among children in rural Bangladesh. Greater efforts are needed to prevent pneumonia among children during their infancy to reduce the chances of subsequent development of wheezing.

Cited by 32 publications

References 30 publications

Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008

Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008

Childhood asthma in low income countries: an invisible killer?

Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children

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