Asthma in Underserved Schoolchildren in Miami, Florida: Results of a School- and Community-Based Needs Assessment

Page, Timothy F.; Beck-Sague, Consuelo M.; Pinzón-Iregui, María C.; Cuddihy, Andrew; Tyler, Timothy F.; Forno, Erick; Dean, Andrew G.; Sivén, Jacqueline; Pottinger, Sharon; Gasana, Janvier

doi:10.3109/02770903.2013.790416

Cited by 12 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies should fulfill the following inclusive criteria: (1) original study of human participants; (2) case-control or cohort design; (3) allele or phenotype frequencies was available; (4) genotype distribution in controls met the Hardy-Weinberg equilibrium (HWE).…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Asthma, one of the most common chronic respiratory disorders among children, is characterized by airway inflammation and hyper‐responsiveness with typical symptoms such as intermittent attacks of breathlessness, wheezing, and coughing. In the last decade, there has been an increasing prevalence of childhood asthma .…”

Section: Introductionmentioning

confidence: 99%

“…9 VDR is correlated with the function of vitamin D for the most part. As a transcriptional mediator, it regulates the effects of the active form of vitamin D 1,25-dihydroxyvitamin D3 [1,25(OH) 2D3]. Previous study showed that VDR regulated gene expression in many cell types, including immune cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta‐analysis

Zhao

Ren

et al. 2016

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Section: Inclusion Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta‐analysis

Zhao

Ren

et al. 2016

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…Page and colleagues took advantage of the CDC Youth Risk Behavior Surveillance System as well as surveys of school nurses and parents of schoolchildren to determine asthma prevalence in Miami, Florida. [6] With these approaches asthma prevalence ranged from 21% using CDC data, 4.9% from nursing surveys and 25% from parental reporting. Wendt and colleagues were able to demonstrate that state-level Medicaid claims could effectively estimate age-adjusted incidence of asthma among low income children in Texas.…”

Section: Epidemiology Of Urban Oldsmentioning

confidence: 99%

Obstructive airway disease in urban populations

Drummond

2014

Current Opinion in Pulmonary Medicine

View full text Add to dashboard Cite

Purpose of Review Obstructive lung disease (OLD), including asthma and chronic obstructive pulmonary disease (COPD), have a more substantial prevalence and morbidity in urban populations. This review highlights recent publications examining the epidemiology, risk factors and interventions concerning OLD in urban populations. Recent Findings Using a variety of approaches, estimates of asthma prevalence in urban populations range from 5–25%. Early life exposures including in utero cigarette smoke, postnatal bisphenol A, home and school particulates and environmental air pollution contribute to increased OLD prevalence and symptom manifestations. Individuals with increased exposure to traffic-related pollution demonstrate abnormal inflammatory and lung function profiles. Obesity, more common in urban populations, is likely both a risk factor for asthma as well as contributor to poor control. Interventions targeted at home-based education and assessments are efficacious and cost-effective in improving outcomes of OLD in urban settings. Summary The burden of OLD in urban populations is driven by maternal, environmental and acquired factors. There are few recent data regarding risk factors and interventions for urban cohorts with COPD. The complex interplay of race, socioeconomic status, environmental exposures and healthcare access in the urban population require continued research efforts.

show abstract

“…Childhood asthma is a chronic inflammatory disorder of the airways (Page et al, 2013). The prevalence of asthma in the 6-7-year-old group is 11.7%, while its prevalence in 13-14 years is 14.1% (Yamamoto and Nagano, 2015).…”

Section: Introductionmentioning

confidence: 99%

A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma

Gao

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. This study aimed to predict pathogenic genes of childhood asthma based on molecular interaction networks and gene expression data. Known pathogenic genes identified from the human protein-protein interaction network were denoted as seed genes, and were included in network A. We extracted sub-network B (pathogenic network), which consisted of genes that interacted with at least two seed genes. We assigned a weight to select the pathogenic genes from this network according to its interactions and co-expressions with the seed genes. We also conducted ClusterONE analysis for the pathogenic network, and determined the statistical significance of the predicted clusters through a significance score (SS). Lastly, we investigated the biological pathways of the seed and candidate genes based on information obtained from the KEGG database. In network A, we identified 172 interactions and 125 genes that interacted with seed genes. In the pathogenic network, we found 51 genes and 102 interactions. The top 10 candidate genes with high weight scores were recorded. The SS of the predicted clusters demonstrated that 3 gene clusters were statistically relevant for childhood asthma. Pathway analysis showed that the seed genes and the top 10 candidate genes were significantly enriched in the same three biological processes. NFKBIA and BIRC3, which were involved in all three biological processes, may therefore be pathogenic genes. Using the network approach, we predicted that the pathogenic genes NFKBIA and BIRC3 are associated with childhood asthma. This information can provide guidelines for future experimental verification of childhood asthma.

show abstract

Asthma in Underserved Schoolchildren in Miami, Florida: Results of a School- and Community-Based Needs Assessment

Abstract: Asthma may be common in MDC schoolchildren, particularly in poor communities. Formidable structural factors limit the caregivers' abilities to manage childhood asthma.

Cited by 12 publications

References 14 publications

Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta‐analysis

Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta‐analysis

Obstructive airway disease in urban populations

A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma

Contact Info

Product

Resources

About