Asthma is associated with endometriosis: A retrospective population-based cohort study

Peng, Yen‐Chun; Su, Shan-Yu; Liao, Wei; Huang, Chien Wen; Hsu, Chung Y.; Chen, Hsuan Ju; Wu, Trong Neng; Ho, Wen Chao; Wu, Chin Ching

doi:10.1016/j.rmed.2017.10.004

Cited by 18 publications

(21 citation statements)

References 34 publications

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“…Phthalate exposure is associated with an increased risk of endometriosis 108 . Endometriosis also increases the risk of spontaneous pregnancy loss 109 and women with asthma also have an increased risk of endometriosis 110 . The sexually dimorphic increased incidence of nonallergic asthma in young women following puberty 111 has been attributed to fluctuations in endogenous sex hormones as menarche, menstrual irregularity, pregnancy, and menopause as well as exogenous sex hormones (oral contraceptives and hormone replacement therapy) influence asthma exacerbations/remissions 112 .…”

Section: Discussionmentioning

confidence: 99%

Asthma and/or hay fever as predictors of fertility/impaired fecundity in U.S. women: National Survey of Family Growth

Turkeltaub¹,

Lockey

Holmes

et al. 2019

Sci Rep

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This study addresses whether asthma and/or hay fever predict fertility and impaired fecundity. The lifetime number of pregnancies (fertility) and spontaneous pregnancy losses (impaired fecundity) in 10,847 women representative of the U.S. population 15 to 44 years of age with histories of diagnosed asthma and/or hay fever are analyzed in the 1995 National Survey of Family Growth using multivariable Poisson regression with multiple covariates and adjustments for complex sampling. Smokers have significantly increased fertility compared to nonsmokers. Smokers with asthma only have significantly increased fertility compared to other smokers. Higher fertility is associated with impaired fecundity (ectopic pregnancy, miscarriage, stillbirth). Women with asthma (with and without hay fever) have significantly higher pregnancy losses than women without asthma. With increasing number of pregnancies, smokers have increased pregnancy losses compared to nonsmokers. Smokers, especially those with asthma only, have increased fertility and require special attention as to their family planning needs, reproductive health, and smoking cessation. Women with asthma, regardless of number of pregnancies, and smokers with higher numbers of pregnancies have high risk pregnancies that require optimal asthma/medical management prenatally and throughout pregnancy. Whether a proinflammatory asthma endotype underlies both the increased fertility and impaired fecundity associated with age and smoking is discussed.

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Section: Discussionmentioning

confidence: 99%

Asthma and/or hay fever as predictors of fertility/impaired fecundity in U.S. women: National Survey of Family Growth

Turkeltaub¹,

Lockey

Holmes

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…23 However, none of these studies controlled for confounding factors. Conversely, conflicting results have been reported for the association between asthma and endometriosis, with most studies reporting a positive association, 6,22,24 one study reporting no association, 25 and one study reporting an inverse association. 26 These contradicting results may be due to differences in controlling for confounding factors and differences in the population from which controls were selected.…”

Section: Ta B L E 3 Multivariable Association Between Family History Of Immune Dysfunction Diseases and Laparoscopically Confirmed Endomementioning

confidence: 97%

Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women

Shafrir

Palmor

Fourquet

et al. 2021

American J Rep Immunol

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Problem: Associations between immune dysfunction conditions (eg, systemic lupus erythematous, rheumatoid arthritis) and endometriosis have been observed in adult women, but not assessed among a younger population. We investigated the association between immune-mediated conditions and endometriosis among young women. Method of Study:This cross-sectional analysis in the Women's Health Study: From Adolescence to Adulthood included 551 participants with surgically diagnosed endometriosis (median age=19) and 652 controls without endometriosis (median age=24). Participants completed an expanded Endometriosis Phenome and Biobanking Harmonization Project questionnaire. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the associations between autoimmune/inflammatory, atopic, chronic pain/fatigue, and endocrine disorders with endometriosis, adjusting for confounders.Results: Participants with any autoimmune and/or inflammatory condition had an increased odds of co-occurring endometriosis (OR: 1.87; CI: 0.92-3.80), as did par-

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“…Several previous studies reported a positive correlation between asthma and endometriosis 17,21,25,26 . A large cohort study from Taiwan reported a 1.5‐fold higher risk of endometriosis in women with asthma compared with women without asthma 21 .…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies of the association between allergic or autoimmune diseases and endometriosis have reported inconsistent results 17–24 . In a cross‐sectional study by Sinaii et al 17 autoimmune diseases (RA, SLE), allergies and asthma were more common in women with endometriosis than in the general population.…”

Section: Introductionmentioning

confidence: 97%

Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case‐control study using a health insurance claims database

Yoshii

Yamana

Ono

et al. 2021

American J Rep Immunol

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Problem Immune responses were reported to be associated with the pathogenesis of endometriosis. However, previous studies of an association between allergic or autoimmune diseases and endometriosis have reported inconsistent results. We investigated the association between allergic or autoimmune diseases and the incidence of endometriosis. Method of study Using a large‐scale health insurance claims database in Japan, we identified patients with endometriosis diagnosed between April 2011 and August 2018. For each case, we identified up to four controls with the same age and registration month. Conditional logistic regression analyses were conducted to evaluate the incidence rate ratio (IRR) of endometriosis in women with allergic diseases (asthma, allergic rhinitis, urticaria, atopic dermatitis, allergic conjunctivitis, and type 1 allergies combined), systemic lupus erythematosus, and rheumatoid arthritis compared with women without these diseases. Results We identified 30 516 cases with endometriosis and 120 976 control participants. Mean age at registration was 30 years. There were significant positive associations between type 1 allergy and endometriosis (IRR, 1.10; 95% confidence interval, 1.06–1.13) and between rheumatoid arthritis and endometriosis (IRR, 1.31; 95% confidence interval, 1.05–1.64). Diagnosis of systemic lupus erythematosus was not associated with increased incidence of endometriosis. Among the different allergic diseases, allergic rhinitis, urticaria, and allergic conjunctivitis were associated with the increased incidence. Conclusion Several allergic diseases were associated with an increased incidence of endometriosis. A higher incidence was also observed in patients with rheumatoid arthritis. Further studies are warranted to elucidate the influence of immune responses on the development of endometriosis.

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Asthma is associated with endometriosis: A retrospective population-based cohort study

Abstract: Compared with women without asthma, women with asthma of reproductive age are at a higher risk of endometriosis. Additional studies are warranted to elucidate the mechanism(s) underlying the association between asthma and a higher risk of endometriosis.

Cited by 18 publications

References 34 publications

Asthma and/or hay fever as predictors of fertility/impaired fecundity in U.S. women: National Survey of Family Growth

Asthma and/or hay fever as predictors of fertility/impaired fecundity in U.S. women: National Survey of Family Growth

Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women

Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case‐control study using a health insurance claims database

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