Asthma is associated with single‐nucleotide polymorphisms in ADAM33

Abstract

This study replicates the recently published association between asthma and ADAM33 gene variants. However, most of the associated SNPs were at non-identical positions in the German, UK and US samples. As linkage disequilibrium is high among the tested SNPs, and there is no known functional polymorphism, either not-tested variants in ADAM33, unknown regulatory elements or a gene in close proximity is responsible for this association.

Association of ADAM33 gene polymorphisms with asthma in Indian children

“…Several groups have examined the association of ADAM33 gene polymorphisms (F+1, V4, ST+4, S2 and ST+5) with asthma in various populations and the findings are summarized in Table 6. Similar to our results, S2 gene polymorphism was reported to be associated with asthma in a UK-only population, 7 in a family-based study on Germans, 19 as well as in African-American, US White and US Hispanic, 20 Japanese 21 and Thai 32 populations. The ST+5 gene polymorphism was associated with a family-based study conducted by Werner et al 19 The ST+4 ADAM33 gene polymorphism was found to be associated with US/UK combined and UK-only populations, 7 in a German family-based study conducted by Werner et al, 19 as well as in Thai case-control 32 and Japanese family-based studies.…”

“…Similar to our result, the F+1 gene polymorphism has shown positive association in a UK-only population and in German family-based studies. 7,19 Recently, Blakey et al 29 conducted transmission disequilibrium and case-control studies, followed by a meta-analysis of all existing data. The meta-analysis showed that F+1 and ST+7 (not performed in this study), which were not associated with asthma in most of the studies, were significantly associated with asthma.…”

“…7,14,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] Several SNPs in ADAM33 have been shown to be significantly associated with asthma, suggesting an important role for ADAM33 in the etiology of asthma. 7,14,19,20,32 However, most data available for ADAM33 and asthma have been obtained from Caucasians, but little data on ADAM33 SNPs associated with asthma and atopic disease are available for Asian populations. 14,19,21,26,33,34 In light of this, we attempted to examine the association of ADAM33 gene polymorphisms F+1 G/A, S2 G/C, ST+4 A/C, ST+5 C/T and V4 C/G with asthma in Indian children.…”

“…7,14,19,20,32 However, most data available for ADAM33 and asthma have been obtained from Caucasians, but little data on ADAM33 SNPs associated with asthma and atopic disease are available for Asian populations. 14,19,21,26,33,34 In light of this, we attempted to examine the association of ADAM33 gene polymorphisms F+1 G/A, S2 G/C, ST+4 A/C, ST+5 C/T and V4 C/G with asthma in Indian children.…”

Typing of single nucleotide polymorphisms by MALDI mass spectrometry: Principles and diagnostic applications

“…SNPs in ADAM33 were found to be associated with asthma and related traits in two German populations [50]. The transmission disequilibrium test (TDT) was applied for association analysis in a family-based study.…”