Asthma mortality among children and adolescents in China, 2008–2018

Shen, Kunling

doi:10.1007/s12519-022-00548-y

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…Our findings have important clinical and public health implications. Childhood asthma is a heavy disease burden in China, which drives the need for prevention and treatment [ 32 ]. However, clinicians and health professionals play less attention to monitoring and intervention for gestational hypertension, gestational diabetes and gestational anaemia because of the lack of conclusive evidence on associations between these maternal complications and childhood asthma.…”

Section: Discussionmentioning

confidence: 99%

Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study

Zhang

et al. 2023

ERJ Open Res

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BackgroundStudies on the associations between maternal complications during pregnancy and childhood asthma are exclusively conducted in Western countries. The findings are mixed and may not be translated to other populations. We aimed to investigate the associations among the Chinese population and to determine whether the associations were mediated through preterm birth, cesarean delivery, low birth weight, and not breastfeeding in the first 6 months.MethodsWe conducted a retrospective cohort study of 166 772 children in Guangzhou, China. Information on maternal gestational hypertension, gestational diabetes, and gestational anemia during pregnancy was extracted from medical records. Ever diagnosis of asthma in children aged 6–12 years was obtained by questionnaire. Logistic regression models and mediation analyses were used to estimate the adjusted odds ratios (aORs) and 95% confidential intervals (CIs) for childhood asthma.ResultsGestational hypertension, gestational diabetes, and gestational anemia during pregnancy were associated with an increased risk of ever diagnosed childhood asthma; the aOR was 1.48 (95%CI 1.37–1.60), 1.71 (95%CI 1.65–1.78) and 1.34 (95%CI 1.26–1.45), respectively. A stronger association was observed for 2 or 3 gestational complications (aOR=2.02, 95%CI 1.93–2.16) than 1 gestational complication (aOR=1.64, 95%CI 1.52–1.77). The aOR for three gestational complications was 1.35 (95%CI 1.26–1.45), 1.63 (95%CI 1.58–1.70), and 1.32 (95%CI 1.24–1.43), respectively, after controlling for the mediators, including preterm birth, cesarean delivery, low birth weight, and not breastfeeding in the first 6 months.ConclusionsGestational hypertension, diabetes, and anemia during pregnancy were associated with childhood asthma, and the associations were partially explained by the mediation effects.

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Section: Discussionmentioning

confidence: 99%

Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study

Zhang

et al. 2023

ERJ Open Res

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“…Adolescent asthma has a higher incidence, mortality and poor treatment compliance, with a more pronounced disease burden compared to younger children. The characteristics of adolescence determine the difference between the management model of asthma in adolescence and that of children and adults (13,14). So this paper is divided into pre-school age, school age and adolescence.…”

Section: Characteristics Of Children With Bronchial Asthmamentioning

confidence: 99%

Relationship between meteorological and environmental factors and acute exacerbation for pediatric bronchial asthma: Comparative study before and after COVID-19 in Suzhou

Guo

Chen²,

Chen³

et al. 2023

Front. Public Health

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ObjectiveClimate and environmental change is a well-known factor causing bronchial asthma in children. After the outbreak of coronavirus disease (COVID-19), climate and environmental changes have occurred. The present study investigated the relationship between climate changes (meteorological and environmental factors) and the number of hospitalizations for pediatric bronchial asthma in Suzhou before and after the COVID-19 pandemic.MethodsFrom 2017 to 2021, data on daily inpatients diagnosed with bronchial asthma at Children's Hospital of Soochow University were collected. Suzhou Meteorological and Environmental Protection Bureau provided daily meteorological and environmental data. To assess the relationship between bronchial asthma-related hospitalizations and meteorological and environmental factors, partial correlation and multiple stepwise regression analyses were used. To estimate the effects of meteorological and environmental variables on the development of bronchial asthma in children, the autoregressive integrated moving average (ARIMA) model was used.ResultsAfter the COVID-19 outbreak, both the rate of acute exacerbation of bronchial asthma and the infection rate of pathogenic respiratory syncytial virus decreased, whereas the proportion of school-aged children and the infection rate of human rhinovirus increased. After the pandemic, the incidence of an acute asthma attack was negatively correlated with monthly mean temperature and positively correlated with PM2.5. Stepwise regression analysis showed that monthly mean temperature and O3 were independent covariates (risk factors) for the rate of acute asthma exacerbations. The ARIMA (1, 0, 0) (0, 0, 0) 12 model can be used to predict temperature changes associated with bronchial asthma.ConclusionMeteorological and environmental factors are related to bronchial asthma development in children. The influence of meteorological and environmental factors on bronchial asthma may be helpful in predicting the incidence and attack rates.

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“…2,3 Although standardized asthma therapy has been aggressively promoted in clinical settings, the clinical control proportion of asthma still falls short of the desired level, resulting in China having one of the highest asthma fatality proportions globally. [4][5][6] Therefore, actively monitoring of asthma patients using effective means is crucial for improving their prognosis and extending their lifespan. It has been established that airway remodeling plays a central role in the pathogenesis of asthma and is a significant component in the early stages of the disease.…”

Section: Introductionmentioning

confidence: 99%

Changes and clinical significance of serum MMP-9, TIMP-1, COX-2, and immune levels in patients with asthma

Ming,

Huang,

Mao

et al. 2023

Allergol Immunopathol

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Objective: To detect serum metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases (TIMP-1), cyclooxygenase-2 (COX-2), and T helper cells 1–T helper cells 2 (Th1–Th2) levels in asthma patients and assess their clinical significance. Methods: A total of 72 patients experiencing acute asthma (acute group), 66 stable asthma patients (stable group), and 60 healthy volunteers (control group) were included in this study. The levels of TIMP-1, COX-2, and Th1–Th2 in patients with acute asthma were measured following treatment with budesonide aerosol inhalation. In addition, the levels of MMP-9, TIMP-1, COX-2 and Th1–Th2 were compared in patients with different severity of acute asthma before and after treatment. Results: The serum levels of MMP-9, TIMP-1, and COX-2 showed an increasing trend in the control, stable, and acute groups, while levels of Th1–Th2 showed a sequential decreasing trend, and the differences were statistically significant. Comparison of lung function indexes among the three groups of patients established a negative correlation between serum MMP-9 and its forced vital capacity% predicted (FEV%pred), TIMP-1, and COX-2, and FEV%pred and forced expiratory volume in 1 s–forced vital capacity (FEV1/FVC) levels, but a positive correlation between Th1–Th2 and FEV1/FVC levels in the acute group. A significant difference was observed on comparing the levels of serum MMP-9, TIMP-1, COX-2, and Th1–Th2 in patients with different conditions in the acute group. Specifically, as the condition worsened, a significant increase in serum MMP-9, TIMP-1, and COX-2 levels but a significant decrease in Th1–Th2 levels was observed. After treatment, we observed a significant decrease in serum MMP-9, TIMP-1, and COX-2 levels but a significant increase in Th1–Th2 levels in the acute group. Conclusion: The serum levels of MMP-9, TIMP-1, COX-2, and Th1–Th2 are valuable indicators reflecting the condition of asthma patients and could be considered promising clinical monitoring indicators.

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Asthma mortality among children and adolescents in China, 2008–2018

Cited by 9 publications

References 39 publications

Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study

Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study

Relationship between meteorological and environmental factors and acute exacerbation for pediatric bronchial asthma: Comparative study before and after COVID-19 in Suzhou

Changes and clinical significance of serum MMP-9, TIMP-1, COX-2, and immune levels in patients with asthma

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