Asthma, obesity, and microbiota: A complex immunological interaction

Menegati, Laura Machado; Oliveira, Érick Esteves de; Oliveira, Bernardo de Castro; Macedo, Gilson Costa; Silva, Flávia Márcia de Castro e

doi:10.1016/j.imlet.2023.01.004

Cited by 9 publications

(4 citation statements)

References 157 publications

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“…Asthma and obesity are both related to an altered microbiota and intestinal barrier, thus, the combination of obesity and allergic asthma has been associated with more severe symptoms, a higher frequency of exacerbation episodes and a lower response to therapy [15]. Although the implication of the intestinal microbiota in both pathologies is well known, the pathophysiological relationship between the fecal content and intestinal function is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children

Córdova,

Tena-Garitaonaindia,

Álvarez-Mercado

et al. 2024

IJMS

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Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function and immunity, and with the composition of the intestinal microbiota and food consumption. In this study, we aimed to establish an organoid model to test the hypothesis that the intestinal content of lean and obese, allergic, asthmatic children differentially regulates epithelial intestinal gene expression. A model of mouse jejunum intestinal organoids was used. A group of healthy, normal-weight children was used as a control. The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (Tnf-tumor necrosis factor, Cd14, Muc13-mucin 13, Tff2-Trefoil factor 2 and Tff3, Cldn1-claudin 1 and 5, Reg3g-regenerating family member 3 gamma, mt-Nd1-NADH dehydrogenase 1 and 6, and mt-Cyb-mitochondrial cytochrome b) via the RAGE-advanced glycosylation end product-specific receptor, NF-κB-nuclear factor kappa b and AKT kinase signal transduction pathways. Fecal homogenates from asthmatic normal-weight and obese children induce a differential phenotype in intestinal organoids, in which the presence of obesity plays a major role.

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Section: Discussionmentioning

confidence: 99%

Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children

Córdova,

Tena-Garitaonaindia,

Álvarez-Mercado

et al. 2024

IJMS

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“…MetS is a cluster of conditions manifested by visceral obesity, hypertension, glucose intolerance, hyperinsulinism, and atherogenic dyslipidemia [82]. As mentioned before, inflammation is a common feature of many of the patho-physiological conditions leading to the MetS, and interestingly, asthma is a chronic inflammatory disease of the lungs that has been shown to have a prevalence in people with a systemic inflammatory chronic disease such as obesity [83]. In the proposed gut-lung axis interplay, gut microbiota affected the immune responsiveness of the lung, thus playing a role in asthma onset.…”

Section: Untangling the Role Of Non-nutritional Components (Contamina...mentioning

confidence: 99%

Ultra-Processed Foods Consumption and Asthma in the Western Diet

Frontela-Saseta,

Finlayson,

Sánchez-Moya

et al. 2024

Dietetics

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Obesity is considered an important risk factor for the onset of asthma, playing a key role in enhancing the disease’s severity. However, there is increasing evidence linking not only obesity but also overweight with a higher risk of asthma. Although the correlation between obesity and asthma has already been reported, several aspects are still not fully elucidated, mainly about the inflammatory processes underlying both diseases. It is well known that Western-type calorically rich diets and overfeeding can act as triggers of chronic metabolic inflammation, but few studies have examined associations between ultra-processed foods (UPFs) intake, despite its positive correlation with obesity, and biomarkers of inflammation. In addition to their nutrient composition, UPF may have chemical additives and contaminants from packaging, whose effects on health and food addiction are still under research. In this review, we provide an overview of the current data that identify the associations between the obese asthma phenotype and UPF consumption, highlighting the potential central role played by the intestinal microbiota.

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“…Recent studies indicate that microbiome-derived metabolites can impact the immune component in the local niche and distant organs [64]. For example, short-chain fatty acids (SCFA) produced by gut bacteria can promote an anti-inflammatory environment by directly binding to G protein-coupled receptors or inhibiting the epigenetic enzymes of histone deacetylase family in epithelial cells and immune cells residing in the gut [64,65]. However, the alteration in the levels of SCFAs is found to be linked with allergic diseases such as asthma.…”

Section: Obesity Asthma and Microbiomementioning

confidence: 99%

Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals

Shailesh,

Bhat,

Janahi

2023

Biomedicines

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Obesity and asthma are two common health issues that have shown increased prevalence in recent years and have become a significant socioeconomic burden worldwide. Obesity increases asthma incidence and severity. Obese asthmatic individuals often experience increased exacerbation rates, enhanced airway remodeling, and reduced response to standard corticosteroid therapy. Recent studies indicate that obesity-associated non-T2 factors such as mechanical stress, hyperinsulinemia, systemic inflammation, adipose tissue mediators, metabolic dysregulation, microbiome dysbiosis, and high-fat-diet are responsible for increased asthma symptoms and reduced therapeutic response in obese asthmatic individuals. This manuscript reviews the recent findings highlighting the role of obesity-associated factors that contribute to airway hyper-reactivity, airway inflammation and remodeling, and immune cell dysfunction, consequently contributing to worsening asthma symptoms. Furthermore, the review also discusses the possible future therapies that might play a role in reducing asthma symptoms by diminishing the impact of obesity-associated non-T2 factors.

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Asthma, obesity, and microbiota: A complex immunological interaction

Cited by 9 publications

References 157 publications

Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children

Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children

Ultra-Processed Foods Consumption and Asthma in the Western Diet

Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals

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