Asthma, oxidant stress, and diet

Greene, Lawrence S.

doi:10.1016/s0899-9007(99)00209-9

Cited by 63 publications

(46 citation statements)

References 97 publications

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“…Firstly, the inflammatory process results in the generation of oxygen free radicals, and antioxidant defence systems are important in controlling inflammation (Greene, 1999). Atopic diseases, in particular asthma and atopic dermatitis, are characterized by increased oxidative stress (Montuschi et al, 1999;Omata et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Vitamin C in breast milk may reduce the risk of atopy in the infant

et al. 2004

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Objective: To assess the effects of maternal dietary and supplement intake of vitamins C and E on breast milk antioxidant composition (vitamin C, a-tocopherol and b-carotene) and their protective potential against the development of atopy in the infant. Design, subjects and methods: Mothers with atopic disease were recruited at the end of gestation and maternal sensitization was assessed by skin-prick testing. The 4-day food records of the mothers and breast milk samples were collected at the infants' age of 1 month. Infants' atopy was defined by the presence of atopic dermatitis during the first year of life and a positive skinprick test reaction at 12 months of age (n ¼ 34). Results: Maternal intake of vitamin C in diet but not as supplement was shown to determine the concentration of vitamin C in breast milk. A higher concentration of vitamin C in breast milk was associated with a reduced risk of atopy in the infant (OR ¼ 0.30; 95% CI 0.09-0.94; P ¼ 0.038), whereas a-tocopherol had no consistent relationship with atopy. The group at risk of suboptimal vitamin C supply from breast milk was identified as infants whose mothers suffer from food hypersensitivity. Conclusion: A maternal diet rich in natural sources of vitamin C during breastfeeding could reduce the risk of atopy in high-risk infants. Sponsorship: The Academy of Finland, the Juho Vainio Foundation and the Finnish Cultural Foundation.

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Section: Introductionmentioning

confidence: 99%

Vitamin C in breast milk may reduce the risk of atopy in the infant

et al. 2004

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“…3 Fruits, vegetables, and whole grain products are rich in antioxidant vitamins (vitamin C, vitamin E, b-carotene) and other substances with antioxidant capacity (including phenolic acids and phytic acid in whole grains 4 5 ). Fish oils are rich sources of n-3 fatty acids.…”

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confidence: 99%

Diet and asthma in Dutch school children (ISAAC-2)

Tabak

Wijga

Meer

et al. 2006

Thorax

103

112

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Background: The rise in the prevalence of asthma in western societies may be related to changed dietary habits. Epidemiological studies in children have shown inverse associations of asthma related outcomes with intake of fruits, vegetables, dairy and whole grain products, and fish. In contrast to most previous studies, we used both questionnaire and clinical data to define asthma. Methods: Intake of the abovementioned foods was studied in relation to asthma in 598 Dutch children aged 8-13 years. Dietary intake was estimated using a parent completed semi-quantitative food frequency questionnaire. Current wheeze and current asthma were defined based on questionnaire data. More complex end points were defined using information on bronchial hyperresponsiveness (BHR) and atopic sensitisation as well. Linear associations were studied using logistic regression analysis and odds ratios presented for the highest versus the lowest tertile of intake. In the final models, adjustments were made for maternal educational level, foreign descent, and total energy intake. Results: The intake of whole grain products and of fish was inversely associated with asthma. Adjusted odds ratios for the independent associations with whole grains and fish were 0.46 (95% CI 0.19 to 1.10) and 0.34 (95% CI 0.13 to 0.85) for current asthma and 0.28 (95% CI 0.08 to 0.99) and 0.12 (95% CI 0.02 to 0.66) for atopic asthma with BHR. Similar results were observed for current wheeze and atopic wheeze with BHR. Intake of (citrus) fruits, vegetables, and dairy products showed no clear associations with asthma end points. Conclusions: Our findings suggest that a high intake of whole grain products and fish may have a protective effect against asthma in children.

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“…Many of the pathophysiological changes associated with allergic diseases are produced by activated inflammatory cells, which generate an excessive amount of oxygen free radicals. A postulated hypothesis is that antioxidants, because of their ability to quench free radicals, prevent chain reactions that could result in lipid peroxidation and damage to cell membranes, ie, of immune cells (3) or DNA, both of which have been suggested to be involved in the allergic disease process (30,31). On the other hand, it has been proposed that several antioxidant nutrients can act as prooxidants at higher doses through a reduction of transition metal ions (32).…”

Section: Tablementioning

confidence: 99%

Use of multivitamin supplements in relation to allergic disease in 8-y-old children

Marmsjö¹,

Rosenlund²,

Kull³

et al. 2009

The American Journal of Clinical Nutrition

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Background: Multivitamins are frequently consumed by children, but it is unclear whether this affects the risk of allergic disease. Objective: We sought to study the association between multivitamin supplementation and allergic disease in 8-y-old children. Design: Data were obtained from a Swedish birth cohort study. Information on lifestyle factors, including use of vitamin supplements, environmental exposures, and symptoms and diagnoses of allergic diseases, was obtained by parental questionnaires. In addition, allergen-specific IgE concentrations of food and airborne allergens were measured in blood samples collected at age 8 y. A total of 2423 children were included in the study. The association between use of vitamin supplements and the selected health outcomes was analyzed with logistic regression. Results: Overall, no strong and consistent associations were observed between current multivitamin use and asthma, allergic rhinitis, eczema, or atopic sensitization at age 8 y. However, children who reported that they started taking multivitamins before or at age 4 y had a decreased risk of sensitization to food allergens (odds ratio: 0.61; 95% CI: 0.39, 0.97) and tendencies toward inverse associations with allergic rhinitis. In contrast, there was no consistent association among children who started to use multivitamins at or after age 5 y. Conclusion: Our results show no association between current use of multivitamins and risk of allergic disease but suggest that supplementation with multivitamins during the first years of life may reduce the risk of allergic disease at school age.

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Asthma, oxidant stress, and diet

Cited by 63 publications

References 97 publications

Vitamin C in breast milk may reduce the risk of atopy in the infant

Vitamin C in breast milk may reduce the risk of atopy in the infant

Diet and asthma in Dutch school children (ISAAC-2)

Use of multivitamin supplements in relation to allergic disease in 8-y-old children

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