Asthma patients with specific genotypes identified for fish oil treatment trial

Abstract

The lifetime prevalence of asthma in California is nearly 20%, and better therapies are needed to manage this common chronic disease. Fish oils containing omega-3 fatty acids are considered a potential therapy for asthma and other inflammatory diseases. Fish oil inhibits the production of arachidonic acid 5-lipoxygenase (ALOX5), an enzyme that exacerbates the lung inflammation that causes asthma. We discuss the genetics of asthma and our preliminary results using a strategy to identify the subgroup of patients who may respond well to treatment with fish oil. These findings, and others, suggest that certain gene polymorphisms of the ALOX5 gene predispose patients to the increased production of inflammatory leukotrienes. Our clinical trials will test the hypothesis that patients with moderate to severe asthma, and with specific high-risk ALOX5 gene sequence variations, will have fewer asthma symptoms when treated with fish oil. The strategy is to decrease the total burden of leukotriene production by supplementing with omega-3 polyunsaturated fatty acids. These studies will also help determine whether genotyping or metabolic profiling (for example, with exhaled breath condensate) can help establish "personalized medicine" for asthma.

Effectiveness of Fish Oil Containing Omega-3 in Improving Symptoms and Lung Function in Asthma Outpatient in Surabaya, Indonesia

“…Genetic polymorphisms of ALOX5 as well as 5lipoxygenase-activating protein (FLAP) are associated with excessive production of leukotrienes. ALOX5 and FLAP are increased RNA messenger in peripheral blood leukocytes in asthmatics and leukotriene concentrations in There is a significant difference P> 0.05; Ho rejected means there is no significant difference P <0.05; Ho accepted means there is a significant difference sputum are greater in asthma patients compared with nonasthma 13 . Environmental factors (eg trigger exposure): To minimize the influence of environmental factors in this study respondents will always be required to report their activities during fish oil therapy, as factors such as contact with triggers, diet, excessive physical activity, etc.…”

“…Leukotriene and prostaglandin E2 contribute to the formation of immunoglobulin E (IgE), an antibody that contributes to the occurrence of an allergic response. This is usually increased in patients with asthma 13 . Although the respondents experienced an improvement in ACT scores, there were several factors that could affect the value of ACT, among others: Gender and age: In table 1, shows the largest number of samples are women than men.…”

“…The antiinflammatory effect on omega-3 is due to the content of EPA which is a competitive substrate with arachidonate so it has the potential to reduce inflammation of the respiratory tract and bronchoconstriction. This has led to a new understanding over the last 30 years that fish oil deficiency can aggravate asthma 13 . This study aims to determine the effect of omega-3 on the control of asthma in patients with asthma in Surabaya who will be given fish oil.…”

Pilot Study of Lung Function Improvement in Peak Expiratory Flow (PEF) Value Using Fish Oil Containing Omega-3 Therapy in Asthma

“…Fish oil inhibits the production of arachidonic acid 5-lipoxygenase (ALOX5), an enzyme that exacerbates inflammation of the lungs that causes asthma. 15 Indonesia, a maritime country, has excellent fish production potential, which can process fish oil, such as salmon, cod, etc. Meanwhile, several studies related to fish oil have also been carried out, which contain omega-3 as conducted by Aprizayanti, 16 and Santoso et al 17 However, there are no studies related to the effect of omega-3 in fish oil on asthma improvement.…”

Omega-3 fatty acids: a potential future treatment for asthma?

“…This varied response to fish oil may possibly be ascribed to genotype determined differences between subjects, and it is quite possible that a gene-diet interaction exists within a subgroup of asthma patients [20]; these particular asthmatic patients may have more than one polymorphism of specific genes in the 5-lipoxygenase (ALOX5) pathway, resulting in an increased production of the AA-derived proinflammatory LTs [20]. Nutraceuticals such as marine oils may play an important role in the treatment of this condition by inhibiting ALOX5, and the resulting proinflammatory mediators.…”