Asthma Relieved by Acetylsalicylic Acid and Nonsteroid Anti-Inflammatory Drugs

Resta, Onofrio; Barbaro, Maria Pia Foschino; Carniméo, N; Bavoso, Pasquale; Picca, V.

doi:10.1159/000194679

Cited by 17 publications

(12 citation statements)

References 7 publications

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“…Ibuprofen has been shown to preserve pulmonary function better than placebo in children with cystic fibrosis and mild lung disease, 6 and there have been anecdotal reports of improvements in forced expiratory volume in 1 second in individuals who have asthma and are challenged with aspirin or other NSAIDs. 7,8 Furthermore, it was suggested recently that in young children, antiinflammatory medications might modulate the immune response to allergens. 9 Viral infections during childhood initially promote a TH1-type, or nonallergic, lymphocyte response, but during the resolution of the illness, a localized TH2, or allergic, lymphocyte response may predominate, and simultaneous allergen exposure could enhance the development of TH2 memory lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Asthma Morbidity After the Short-Term Use of Ibuprofen in Children

et al. 2002

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ABSTRACT.Objective. To test the hypothesis that short-term use of ibuprofen increases asthma morbidity in children.Methods. A randomized, double-blind, acetaminophen-controlled clinical trial was conducted. Children who had asthma and a febrile illness were randomly assigned to receive either acetaminophen suspension or ibuprofen suspension for fever control. Rates of hospitalization and outpatient visits for asthma during follow-up were compared by randomization group.Results. A total of 1879 children receiving asthma medications were studied. Rates of hospitalization for asthma did not vary significantly by antipyretic assignment; compared with children who were randomized to acetaminophen, the relative risk for children who were assigned to ibuprofen was 0.63 (95% confidence interval: 0.25-1.6). However, the risk of an outpatient visit for asthma was significantly lower in the ibuprofen group; compared with children who were randomized to acetaminophen, the relative risk for children who were assigned to ibuprofen was 0.56 (95% confidence interval: 0.34 -0.95).Conclusion. Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks. Whether the observed difference in morbidity according to treatment group is attributable to increased risk after acetaminophen use or a decrease after ibuprofen cannot be determined. These data provide evidence of the relative safety of ibuprofen use in children with asthma. Pediatrics 2002;109(2). URL: http:// www.pediatrics.org/cgi/content/full/109/2/e20; ibuprofen, NSAIDs, acetaminophen, clinical trial, asthma, bronchospasm.ABBREVIATIONS. NSAIDs, nonsteroidal antiinflammatory drugs; CI, confidence interval.

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Section: Discussionmentioning

confidence: 99%

Asthma Morbidity After the Short-Term Use of Ibuprofen in Children

et al. 2002

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“…[1][2][3]6,7 The benefit was reported to occur within 30 -60 min after of aspirin ingestion, and to last several hours, and in one case 3 days. 3 Symptom improvement was observed only with cyclooxygenase inhibitors, and it was hypothesized that the effect was caused by a diversion of the arachidonic acid metabolism toward cyclooxygenase products. 2 Our patient did not have asthma but did report bronchial hyper-responsiveness to volatile chemicals.…”

Section: Discussionmentioning

confidence: 99%

“…The available data suggest a prevalence of 0.5-2% among asthmatic patients. 3,7,10 Upper-respiratory-tract inflammation and chronic rhinosinusitis frequently reduce olfaction and decrease quality of life, [11][12][13] and the available therapies are limited and their effects transitory. 14,15 A study is needed on whether aspirin-tolerant patients with chronic rhinosinusitis and/or asthma benefit from ingested or topical aspirin.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Chronic Rhinitis Under Aspirin

Merkonidis

Gudziol²,

Cecchini

et al. 2012

Respir Care

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In a subset of aspirin-tolerant asthmatics, administration of aspirin improves respiratory symptoms. We present a patient with chronic rhinosinusitis with nasal polyps who exhibited relief of nasal obstruction and nasal discharge and improvement in the sense of smell following oral administration of 150 mg of aspirin daily. Improvement in the patency of the nasal passages was documented by nasal endoscopy and magnetic resonance imaging. Improvement of olfactory function was documented by validated psychophysical olfactory testing and by means of olfactory event-related potentials.

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“…Most patients with asthma tolerate aspirin without problems and some patients with asthma improve when challenged with aspirin and other nonsteroidal antiinflammatory drugs (24)(25)(26). In aspirin-tolerant patients, the increase in cysteinyl leukotrienes and reduction in prostaglandin E 2 may be counterbalanced or overwhelmed by reductions in the bronchoconstrictors prostaglandin D 2 , prostaglandin F 2 , and the thromboxanes (27) triggered by COX-1 inhibition.…”

Section: Discussionmentioning

confidence: 99%

Aspirin and Decreased Adult-Onset Asthma

Barr

Kurth

Stampfer

et al. 2007

Am J Respir Crit Care Med

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Rationale:In an observational cohort study, women who selfselected for frequent aspirin use developed less newly diagnosed asthma than women who did not take aspirin. Objective: To explore whether low-dose aspirin decreased the risk of newly diagnosed asthma in a randomized, double-blind, placebocontrolled trial. Methods: The Physicians' Health Study randomized 22,071 apparently healthy male physicians, aged 40-84 yr at baseline and tolerant of aspirin, over an 18-wk run-in period, to 325 mg aspirin or placebo on alternate days. The aspirin component was terminated after 4.9 yr due principally to the emergence of a statistically extreme 44% reduction in risk of first myocardial infarction among those randomly assigned to aspirin. Measurements: Physicians could self-report an asthma diagnosis on questionnaires at baseline, 6 mo, and annually thereafter. Asthma was not an a priori endpoint of the trial. Results: Among 22,040 physicians without reported asthma at randomization, there were 113 new asthma diagnoses in the aspirin group and 145 in the placebo group. The hazard ratio was 0.78 (95% confidence interval, 0.61-1.00; p ϭ 0.045). This apparent 22% lower risk of newly diagnosed asthma among those assigned to aspirin was not modified by baseline characteristics including smoking, body mass index, or age. Conclusions: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men. This result requires replication in randomized trials designed a priori to test this hypothesis; it does not imply that aspirin improves symptoms in patients with asthma.Keywords: asthma; aspirin; NSAIDs; analgesics; obstructive airways disease Asthma prevalence has increased in the United States since the late 1970s, particularly among children (1), and now approaches that of high-prevalence countries such as the United Kingdom and Australia (2). The increase in the United States coincided with a substantial decline in the use of aspirin as an antipyretic and analgesic in the late 1970s and 1980s (3). The switch from aspirin to other over-the-counter analgesics (e.g., acetamino- AT A GLANCE COMMENTARY Scientific Knowledge on the SubjectAspirin is known to worsen symptoms among a minority of patients with asthma. Recent epidemiologic and bench studies, however, suggest that frequent aspirin use might reduce the risk of developing asthma among adults. What This Study Adds to the FieldThis secondary analysis of a large randomized, double-blind, placebo-controlled trial of aspirin-tolerant men showed that randomization to aspirin reduced the risk of adult-onset asthma.phen) was particularly pronounced among children due to reports of a link between aspirin and Reyes syndrome in the early 1980s (4, 5). Because aspirin might promote Th1 and inhibit Th2 phenotypes (6, 7), Varner and colleagues hypothesized that the reduction in pediatric aspirin use in the United States contributed, in part, to the increase in asthma prevalence (3).In a large observational co...

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Asthma Relieved by Acetylsalicylic Acid and Nonsteroid Anti-Inflammatory Drugs

Cited by 17 publications

References 7 publications

Asthma Morbidity After the Short-Term Use of Ibuprofen in Children

Asthma Morbidity After the Short-Term Use of Ibuprofen in Children

Improvement of Chronic Rhinitis Under Aspirin

Aspirin and Decreased Adult-Onset Asthma

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