Asthma susceptible genes in children

Ruan, Zhen; Shi, Zhaoling; Zhang, Guocheng; Kou, Jiushe; Ding, Hui

doi:10.1097/md.0000000000023051

Cited by 11 publications

(10 citation statements)

References 51 publications

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“…The East Asian population showed a lower risk of asthma association in all the models used, and relative to the other ethnicity subgroups, it showed the lowest risk, however, the association is still present. Our results are inconsistent with past meta-analyses since most studies about Chinese populations reported the association of IL-13 SNP rs20541 with asthma risk, instead of rs1800925 [ 16 , 45 , 46 ]. Though previous studies did not associate the polymorphism with the progression of the disease [ 29 ], our findings reported a positive association with asthma; hence, it is suggested that genetic diversity might be present in the East Asian population.…”

Section: Discussioncontrasting

confidence: 99%

Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis

Gaceja,

Ancheta,

Buna

et al. 2023

Asia Pacific Allergy

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Background: The interleukin-13 (IL-13) gene has been associated with allergic asthma pathogenesis due to its role in IgE synthesis. The IL-13 single nucleotide polymorphism (SNP) rs1800925 has been implicated in exacerbated allergic asthma symptoms in different ethnicities. Objectives: To determine the association of IL-13 SNP rs1800925 with allergic asthma symptoms in the Asian population Methods: Major databases were searched for studies on the association of IL-13 rs1800925 with allergic asthma in various Asian populations published between 2010 and February 2022. The odds ratio with 95% CI was obtained from included studies, and the association was evaluated using different genetic models. Heterogeneity was explored by subgroup analyses and I 2 statistic evaluation. Results: Eleven studies with a total of 2895 cases and 2914 controls were included in this meta-analysis. The majority of the cases exhibited CC genotype (n = 1897), followed by CT genotype (n = 852), and TT genotype (n = 146). IL-13 rs1800925 was significantly associated with increased allergic asthma risk in the Asian population under the recessive model (TT vs CT/CC: OR, 1.48; 95% CI, 1.14–1.93; P = 0.37; I 2 = 08%). Subgroup analyses by ethnicity showed an elevated risk of allergic asthma in West Asians (Iranian and Saudi Arabian) followed by East Asians (Chinese and Japanese) using the recessive model. Both age groups (adults and children) exhibited an increased risk of allergic asthma. Conclusion: This meta-analysis provides evidence that IL-13 SNP rs1800925 is a risk factor for allergic asthma in the Asian Population. It also suggests that rs1800925 is a risk factor present in both adult and children population.

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Section: Discussioncontrasting

confidence: 99%

Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis

Gaceja,

Ancheta,

Buna

et al. 2023

Asia Pacific Allergy

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“…Among childhood, asthma is accepted as the most common chronic disease. Recently, accumulating evidence researched the function role of VDR gene polymorphism in childhood asthma, and four SNPs, including BsmI (rs1544410), ApaI (rs7975232), FokI (rs2228570), and TaqI (rs731236), were the main gene locuses (3,29). Based on the meta-analysis, our data showed that FokI (rs2228570) could significantly affect the risk of childhood asthma across co dominant model and dominant model, especially among Caucasians.…”

Section: Discussionmentioning

confidence: 74%

Meta-Analysis of Vitamin D Receptor Gene Polymorphisms in Childhood Asthma

Zhou

2022

Front. Pediatr.

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We conducted the systematic review to investigate the potential relationship between the vitamin polymorphisms of D receptor (VDR) gene and childhood asthma. Relevant studies researching on VDR polymorphisms and asthma susceptibility were searched throughout Embase, PubMed, China Science and technology journal database (CQVIP), etc. till 12 April, 2021. We calculated the pooled odds ratios (OR) and its 95% confidence interval (CI) using RevMan 5.3 software and Stata 11.0. FokI (rs2228570) could significantly affect childhood asthma risk across co dominant model (Ff vs. FF: OR (95%CI) = 0.82 (0.65, 1.02), P = 0.071) and dominant model (ff+Ff vs. FF: OR (95%CI) = 0.77 (0.63, 0.95), P = 0.016), especially among Caucasians in additive model (f vs. F: OR (95%CI) = 0.63 (0.43, 0.92), P = 0.015) and dominant model (ff+Ff vs. FF: OR (95%CI) = 0.67 (0.51, 0.88), P = 0.004). TaqI (rs731236) was significantly related with childhood asthma in additive model (t vs. T: OR (95%CI) = 0.45 (0.23, 0.89), P = 0.022), co dominant model (Tt vs. TT: OR (95%CI) = 0.36 (0.17, 0.77), P = 0.009), and dominant model (tt+Tt vs. TT: OR (95%CI) = 0.36 (0.15, 0.87), P = 0.024) among Asian, as well as population-based subgroup in co dominant model (Tt vs. TT: OR (95%CI) = 0.53 (0.31, 0.94), P = 0.029). However, no evidence supported the role of ApaI (rs7975232) and BsmI (rs1544410) polymorphisms in childhood asthma. FokI and TaqI polymorphisms were found to be related with the susceptibility of childhood asthma. However, it seems that ApaI and BsmI polymorphisms are not related with childhood asthma susceptibility.

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“…Particular genes directly impact the immune response, both humoral and cellular. For instance, IL-13+2044G/A, IL-4-590C/T polymorphisms are associated with an increased risk of childhood asthma development ( 20 ).…”

Section: Immunological Genetic and Epigenetic Factors Of Allergy Deve...mentioning

confidence: 99%

Promising Immunomodulatory Effects of Bacterial Lysates in Allergic Diseases

et al. 2022

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In light of an escalating prevalence of allergic disorders, it is crucial to fully comprehend their pathophysiology and etiology. Such knowledge would play a pivotal role in the search for new therapeutic approaches concerning not only diseases’ symptoms, but also their underlying causes. The hygiene hypothesis indicates a high correlation between limited exposure to pathogens in early childhood and the risk of developing allergic disorders. Bearing in mind the significance of respiratory and digestive systems’ mucous membrane’s first-line exposure to pathogens as well as its implications on the host’s immune response, a therapy targeted at aforesaid membranes could guarantee promising and extensive treatment outcomes. Recent years yielded valuable information about bacterial lysates (BLs) known for having immunomodulatory properties. They consist of antigen mixtures obtained through lysis of bacteria which are the most common etiologic agents of respiratory tract infections. They interact with dendritic cells located in the mucous membranes of the upper respiratory tract and the gastrointestinal tract by toll-like receptors. The dendritic cells present acquired antigens resulting in innate immune response development on the release of chemokines, both stimulating monocytes and NK cells maturation and promoting polymorphonuclear neutrophil migration. Moreover, they influence the adaptive immune system by stimulating an increase of specific antibodies against administered bacterial antigens. The significance of BLs includes not only an anti-inflammatory effect on local infections but also restoration of Th1/Th2 balance, as demonstrated mainly in animal models. They decrease Th2-related cytokine levels (IL-4, IL-13) and increase Th1-related cytokine levels (IFN-γ). The reestablishment of the balance of the immune response leads to lowering atopic reactions incidence which, in addition to reduced risk of inflammation, provides the alleviation and improvement of clinical manifestations of allergic disorders. In this review, we hereby describe mechanisms of BLs action, considering their significant immunomodulatory role in innate immunity. The correlation between local, innate, and adaptive immune responses and their impact on the clinical course of allergic disorders are discussed as well. To conclude our review, we present up-to-date literature regarding the outcomes of BLs implemented in atopic dermatitis, allergic rhinitis, and asthma prevention and treatment, especially in children.

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Asthma susceptible genes in children

Abstract: Supplemental Digital Content is available in the text

Cited by 11 publications

References 51 publications

Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis

Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis

Meta-Analysis of Vitamin D Receptor Gene Polymorphisms in Childhood Asthma

Promising Immunomodulatory Effects of Bacterial Lysates in Allergic Diseases

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