Asthma symptoms in early childhood – what happens then?

Goksör, Emma; Åmark, Mainor; Alm, Bernt; Gustafsson, Per; Wennergren, Göran

doi:10.1080/08035250500499440

Cited by 68 publications

(87 citation statements)

References 28 publications

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“…Our results are in line with results from two Scandinavian cohorts of young children (<2 years of age) admitted to hospital for severe wheezing, where 40–49% of patients had asthma at the age of 5–7 years [17, 37]. Further follow-up showed that the high risk of asthma persisted into adulthood [15]. Taken together, these data may be used in paediatric hospitals and departments to counsel parents of preschool children with EVW on the expected outcome of wheeze in these patients.…”

Section: Discussionsupporting

confidence: 90%

Severe episodic viral wheeze in preschool children: High risk of asthma at age 5–10 years

Kappelle

Brand

2012

Eur J Pediatr

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In population studies, most children with episodic viral wheeze (EVW) become symptom free by 6 years. We studied the outcome of children with severe EVW, treated and followed up in hospital. We followed up 78 children <4 years, managed by paediatricians for severe EVW, to the age of 5–10 years. We recorded respiratory symptoms, spirometry and exhaled nitric oxide (FeNO). At follow-up, 42 children (54%) had current wheeze or dyspnoea, and 52 (67%) had current asthma. There was no significant difference between children with and without current asthma in FEV1 (p = 0.420), but FeNO was higher in children with current asthma (median (interquartile range) 14.5 (11.25–21.50) ppb) than in those without (12.0 (10.0–13.8) ppb, p = 0.020). Positive family history of asthma was the only factor associated with current asthma (odds ratio 8.77, 95% CI 2.88–26.69, p < 0.001). This remained significant after adjustment for duration of follow-up, gender and parental smoking. Conclusion. Severe EVW at preschool age has a high risk of asthma at age 5–10 years, and this is reinforced by a positive family history of asthma and to elevated FeNO levels.

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Section: Discussionsupporting

confidence: 90%

Severe episodic viral wheeze in preschool children: High risk of asthma at age 5–10 years

Kappelle

Brand

2012

Eur J Pediatr

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“…Such different “phenotypes” of asthma may vary in response to treatment [1], in prognosis [2], in inflammatory patterns [3], and in susceptibility to environmental exposure [4]. Identifying possible subphenotypes has therefore rendered increasing interest in recent years [5, 6].…”

Section: Introductionmentioning

confidence: 99%

The Heterogeneity of Asthma Phenotypes in Children and Young Adults

et al. 2012

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Objective. Genetic heterogeneity and risk factor distribution was analyzed in two previously proposed asthma phenotypes. Method. A sample of 412 subjects was investigated at 7-8, 12-13, and 21-22 years of age with questionnaires, skin prick tests, and genetic analysis of IL-4 receptor (IL4R) single-nucleotide polymorphisms. The sample was subdivided in one group with no asthma, and two groups with asthma separated by age of onset of symptoms, namely, early onset asthma (EOA) and late onset asthma (LOA). Risk factors and IL4R markers were analyzed in respect to asthma phenotypes. Results. EOA and LOA groups were both associated with atopy and a maternal history of asthma. Female gender was more common in LOA, whereas childhood eczema, frequent colds in infancy, and a paternal history of asthma were more common in EOA. The AA genotype of rs2057768 and the GG genotype of rs1805010 were more common in LOA, whereas the GG genotype of rs2107356 was less common in EOA. Conclusion. Our data suggest that early and late onset asthma may be of different endotypes and genotypes.

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“…Sensitization (and subsequent allergen exposure) should, however, be viewed as a prognostic marker, Fig. 2.2 The airways and lungs of preterm babies are vulnerable to outside exposures, and preterm birth is associated with later manifestations of respiratory tract diseases since early wheezing disorders combined with current allergy are an important risk factor for asthma later in life [80].…”

Section: Tobacco Smoke and Nicotine Exposurementioning

confidence: 99%

Special Considerations in Preschool Age

Kere

2019

Severe Asthma in Children and Adolescents

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Asthma symptoms in early childhood – what happens then?

Cited by 68 publications

References 28 publications

Severe episodic viral wheeze in preschool children: High risk of asthma at age 5–10 years

Severe episodic viral wheeze in preschool children: High risk of asthma at age 5–10 years

The Heterogeneity of Asthma Phenotypes in Children and Young Adults

Special Considerations in Preschool Age

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