Asthma treatment and growth

Shaw, Nicholas; Fraser, N C; Weller, P

doi:10.1136/adc.77.4.284

Cited by 15 publications

(6 citation statements)

References 40 publications

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“…The magnitude of this effect may be influenced by the dose delivery system as well as the systemic bioavailability of the inhaled steroid used. 25 This effect may be most pronounced over the first few weeks of treatment. 26 Long term studies are difficult due to a number of confounding factors including the plethora of drugs, delivery systems, compliance, and disease severity, but there is no clear evidence that final height is compromised following inhaled GC therapy in children with asthma.…”

Section: Asthma Eczema and Hay Fevermentioning

confidence: 99%

The impact of corticosteroids on growth and bone health

Mushtaq

2002

Archives of Disease in Childhood

151

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Section: Asthma Eczema and Hay Fevermentioning

confidence: 99%

The impact of corticosteroids on growth and bone health

Mushtaq

2002

Archives of Disease in Childhood

151

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“…Prophylactic anti-inflammatory treatment with glucocorticoids in asthmatic children should aim at optimal disease control and make normal development and growth possible 1. In most schoolchildren this can be achieved with recommended daily doses of 200–400 μg of an inhaled glucocorticoid administered from a metered dose inhaler with a spacer, or with 100–200 μg from a dry powder inhalation device 2…”

mentioning

confidence: 99%

A randomised controlled trial of short term growth and collagen turnover in asthmatics treated with inhaled formoterol and budesonide

Heuck

Heickendorff²,

Wolthers³

2000

Archives of Disease in Childhood

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Aims-To determine eVects on short term growth and collagen turnover of adding formoterol (Eformoterol) to half the glucocorticoid dose in children with asthma, treated with inhaled budesonide (Pulmicort Turbuhaler). Design-A randomised double blind, placebo controlled crossover study with two six-week periods. Setting-Outpatient clinic in secondary referral centre. Subjects-A total of 27 prepubertal children aged 6-13 years. Interventions-Formoterol 12 µg and dry powder budesonide 100 µg twice daily in one period; placebo and dry powder budesonide 200 µg twice daily in the other. Outcome measures-Primary outcome measures were lower leg growth rate, and serum and urine markers of type I and type III collagen turnover. Secondary outcome measures were inflammation markers in serum, and parameters of asthma control. Results-During budesonide 200 µg twice daily treatment, mean lower leg growth rate was 0.14 mm/week (p = 0.02) lower than during the formoterol and budesonide period. Similar statistically significant eVects on markers of collagen turnover were found, whereas inflammation markers and asthma control did not vary statistically significantly between the two periods. Conclusions-In children treated with inhaled glucocorticoids, halving the dose and adding formoterol is associated with faster short term growth and an increase in markers of collagen turnover, with no loss of asthma control.

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“…Regarding the suppression of the hypothalamus-hypophysis-adrenal cortex axis, there is no sound evidence of this adverse effect in children (40,41,46) .…”

Section: Inhaled Corticosteroids and Growthmentioning

confidence: 99%

“…Glucocorticoids are known as potent inhibitors of growth hormone secretion and action, of IGF-1, of collagen synthesis, and of suprarenal androgen production; the most important factor of growth arrest or delay is, however, still uncertain (45)(46)(47)(48)(49)(50)(51) .…”

Section: Inhaled Corticosteroids and Growthmentioning

confidence: 99%

Linear growth in asthmatic children

et al. 2003

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Asthma is the most frequent chronic inflammatory disease in childhood, and its prevalence has increased remarkably over the last decades. Therefore, the scientific community became interested in studying the growth of the affected children. The relationship between asthma and growth suffers the influence of the clinical picture, of therapeutics, but the different study methods make it difficult to distinguish the factors responsible for the growth retardation detected by some authors. This review has the purpose of providing an overall outlook on this matter. (J Pneumol 2003;29(1):36-42)

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Asthma treatment and growth

Cited by 15 publications

References 40 publications

The impact of corticosteroids on growth and bone health

The impact of corticosteroids on growth and bone health

A randomised controlled trial of short term growth and collagen turnover in asthmatics treated with inhaled formoterol and budesonide

Linear growth in asthmatic children

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