Asthma versus chronic obstructive pulmonary disease, the Dutch versus British hypothesis, and role of interleukin-5

Abstract

Although patients with ACOS or overlap symptoms may be an exception, overall there appears to be more evidence supporting that asthma and COPD are distinct processes. Targeting eosinophils with anti-IL-5 therapy appears to be an exciting pathway in the properly selected patient with asthma and recent data also supports its use in COPD.

Common manifestation of airway diseases: chronic obstructive pulmonary disease and asthma bronchiale

“…According to dutch hypothesis asthma bronchiale, chronic bronchitis and emphysema are a common genetical disease with different manifestations, in pathogenesis airway hyperreactivity is the main factor. [3][4][5][6][7][8] According to british hypothesis chronic bronchitis, emphysema and asthma bronchialeare three different disease with three different clinical manifestations, three different origin and three different prognosis. Reversibility can help to differentiation.…”

“…Reversibility can help to differentiation. [3][4][5][6][7][8][9] In the opposite part, international guidelines are dealing with asthma bronchiale and COPD common manifestation. According to GINA 2017, inhalatory exposition of injurable materials (mainly smoking) can cause a mixed inflammatory typical process of asthma bronchiale and COPD in patients with asthma bronchiale.…”

“…Clinical symptoms can hardly differentiate COPD and asthma bronchial. [1][2][3][4][5][6][7][8] Significant smoking anamnesis can support COPD origin, but some asthma bronchialetic patients are smoker, also. 9 Most of the asthma bronchialetic patients have paroxismatic dyspnoic wheezing in the early morning or after exercise.…”

“…9 Most of the asthma bronchialetic patients have paroxismatic dyspnoic wheezing in the early morning or after exercise. [1][2][3][4][5][6][7][8][9] In COPD, the dyspnoea is progressive and it is manifested during exercise at first. Hey fever with obstructive pulmonary disease support the definition of allergic asthma bronchiale bronchiale, but there is a significant portion of COPD patients with hey fever as co-morbidity.…”

“…10 Asthma bronchiale and COPD together show similar clinical feature as asthma bronchiale. [1][2][3][4][5][6][7][8] Lung function is crucial for differentiation. In asthma bronchiale, most of the cases have reversible airway obstruction, lung function goes to normal values.…”