Astilbin Attenuates Cadmium-Induced Adipose Tissue Damage by Inhibiting NF-κB Pathways and Regulating the Expression of HSPs in Chicken

Sun, Jianxu; Jiao, Zitao; Zhu, Weifeng; Li, Xiuyu; Wang, Panpan; Tai, Tiange; Wang, Yuxi; Wang, Haibin; Shi, Guangliang

doi:10.1007/s12011-022-03327-y

Cited by 7 publications

(2 citation statements)

References 68 publications

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“…However, the antioxidant defense of adipose tissue concerning Cd exposure has yet to be well-studied. It has been found that toxic concentration of Cd exposure by oral gavage showed an activity decrease in SOD, CAT, and GPx [ 247 ]. MTs play a critical role in adipogenesis and maintaining adipocyte size beyond their chelating capacity [ 210 ].…”

Section: Adipose Tissue Antioxidant Defensementioning

confidence: 99%

Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

Moroni-González

Sarmiento-Ortega

Díaz

et al. 2023

Toxics

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Cadmium has been well recognized as a critical toxic agent in acute and chronic poisoning cases in occupational and nonoccupational settings and environmental exposure situations. Cadmium is released into the environment after natural and anthropogenic activities, particularly in contaminated and industrial areas, causing food pollution. In the body, cadmium has no biological activity, but it accumulates primarily in the liver and kidney, which are considered the main targets of its toxicity, through oxidative stress and inflammation. However, in the last few years, this metal has been linked to metabolic diseases. The pancreas–liver–adipose axis is largely affected by cadmium accumulation. Therefore, this review aims to collect bibliographic information that establishes the basis for understanding the molecular and cellular mechanisms linked to cadmium with carbohydrate, lipids, and endocrine impairments that contribute to developing insulin resistance, metabolic syndrome, prediabetes, and diabetes.

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Section: Adipose Tissue Antioxidant Defensementioning

confidence: 99%

Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

Moroni-González

Sarmiento-Ortega

Díaz

et al. 2023

Toxics

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“…Oxidative stress can cause inflammation via a number of mechanisms, including Nucleotide-binding oligomerization domain-like receptors, TOLL receptors, and NFκB pathways ( 66 ). Simultaneously, inflammation can result in oxidative stress ( 67 , 68 ). The oxidative stress level in the ovarian cortex around endometriotic cysts was much higher than in dermoid cysts ( 69 ).…”

Section: Ems Causes Gcs Destructionmentioning

confidence: 99%

Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells

Fan,

Yuan,

et al. 2023

Front. Endocrinol.

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Infertility and menstrual abnormalities in endometriosis patients are frequently caused by aberrant follicular growth or a reduced ovarian reserve. Endometriosis typically does not directly harm the oocyte, but rather inhibits the function of granulosa cells, resulting in a decrease in oocyte quality. Granulosa cells, as oocyte nanny cells, can regulate meiosis, provide the most basic resources required for oocyte development, and influence ovulation. Endometriosis affects oocyte development and quality by causing granulosa cells apoptosis, inflammation, oxidative stress, steroid synthesis obstacle, and aberrant mitochondrial energy metabolism. These aberrant states frequently interact with one another, however there is currently relatively little research in this field to understand the mechanism of linkage between abnormal states.

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The antagonism mechanism of astilbin against cadmium-induced injury in chicken lungs via Treg/Th1 balance signaling pathway

Shi,

Tai,

Miao

et al. 2024

Ecotoxicology and Environmental Safety

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Astilbin Attenuates Cadmium-Induced Adipose Tissue Damage by Inhibiting NF-κB Pathways and Regulating the Expression of HSPs in Chicken

Cited by 7 publications

References 68 publications

Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells

The antagonism mechanism of astilbin against cadmium-induced injury in chicken lungs via Treg/Th1 balance signaling pathway

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