Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-α and its associated MMP-9 activity and CD44 expression

Yi, Hongwei; Lü, Xiaomin; Fěng, Fang; Wang, Jun; Xu, Qiang

doi:10.1016/j.intimp.2008.06.006

Cited by 28 publications

(14 citation statements)

References 31 publications

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“…Li et al, 2016), flavokawin B , kaempferol (K. Y. Kim et al, 2016), chrysin (Zaric et al, 2015), butein (Woo et al, 2016), naringenin (R. F. Li et al, 2015), catechin (L. Zhang et al, 2014), genistein (I. G. Kim et al, 2014), apigenin (Gonzalez-Mejia et al, 2010;Jayasooriya et al, 2012), dorsmanin F (Kuete et al, 2015), astilbin (H. W. Yi et al, 2008), EGCG (Annabi et al, 2007;, icaraside ), phloridzin (Arumuggam et al, 2017), isochamaejasmin (S. D. Zhang et al, 2015, MF derivatives (Wudtiwai et al, 2011), icaritin (Q. Li et al, 2013, FEOJ (W. S. Lee et al, 2015), casticin (Kikuchi et al, 2013), chalcone , deguelin (S. Yi et al, 2015), morin (C. Park et al, 2014), medicarpin (Gatouillat et al, 2015), Antho 50 (Alhosin et al, 2015), rotenone (Estrella-Parra et al, 2014), glabridin (H. L. , hispidulin (H. , oroxylin A (Hui et al, 2016), rhamnazin (Philchenkov & Zavelevych, 2015), wogonoside (Y. Chen et al, 2013) (Nicolini et al, 2014), phloretin (Kobori, Iwashita, Shinmoto, & Tsushida, 1999), and xanthohumol (Lust et al, 2005) with their chief working mechanisms in leukemia cells.…”

Section: Inhibition Of Survival Involved Signaling Pathwaysmentioning

confidence: 99%

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Leukemia therapy by flavonoids: Future and involved mechanisms

Saraei

Marofi

Naimi

et al. 2018

Journal Cellular Physiology

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Flavonoids are a varied family of phytonutrients (plant chemicals) usually are detected in fruits and vegetables. In this big family, there exist more than 10,000 members that is separated into six chief subtypes: isoflavonols, flavonoenes, flavones, flavonols, anthocyanins, and chalcones. The natural compounds, such as fruits, have visible positive effects in regulating of survival involved signaling pathways that performance as the regulator of cell survival, growth, and proliferation. Researchers have established that commonly consumption up flavonoids decreases incidence and development risk of certain cancers, especially leukemia. Flavonoids have been able to induce apoptosis and stimulate cell cycle arrest in cancer cells via different pathways. Similarly, they have antiangiogenesis and antimetastasis capability, which were shown in wide ranges of cancer cells, particularly, leukemia. It seems that flavonoid because of their widespread approval, evident safety and low rate of side effects, have hopeful anticarcinogenic potential for leukemia therapy. Based on the last decade reports, the most important acting mechanisms of these natural compounds in leukemia cells are stimulating of apoptosis pathways by upregulation of caspase 3, 8, 9 and poly ADP‐ribose polymerase (PARP) and proapoptotic proteins, particularly Bax activation. As well, they can induce cell cycle arrest in target cells not only via increasing of activated levels of p21 and p53 but also by inhibition of cyclins and cyclin‐dependent kinases. Furthermore, attenuation of neclear factor‐κB and signal transducer and activator of transcription 3 activation, suppression of signaling pathway and downregulation of intracellular antiapoptotic proteins are other significant antileukemic function mechanism of flavonoids. Overall, it appears that flavonoids are promising and effective compounds in the field of leukemia therapy. In this review, we tried to accumulate and revise most promising flavonoids and finally declared their major working mechanisms in leukemia cells.

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Section: Inhibition Of Survival Involved Signaling Pathwaysmentioning

confidence: 99%

“…. Besides, in astilbin-treated acute T-cell leukemia Jurkat cells, MMP-9 secretion was reduced and the expression of CD44 and tumor necrosis factor-α (TNF-α), which involved in cell migration, was diminished significantly (H. W Yi, Lu, Fang, Wang, & Xu, 2008)…”

mentioning

confidence: 99%

Leukemia therapy by flavonoids: Future and involved mechanisms

Saraei

Marofi

Naimi

et al. 2018

Journal Cellular Physiology

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“…For instance, a co‐culture of macrophage and adipocytes was used to show the anti‐obesity activity of naringenin (Hirai and others ; Yoshida and others ; Yoshida and others ). Further, the effect of anthocyanins on the development of angiogenesis (tube formation) was investigated using a HUVEC/fibroblast contact co‐culture system (Tanaka and others ), whereas the effect of grape seed procyanidin extract and astilbin on the adhesion properties of T‐cells to endothelial cells was determined using HUVEC/Jurkat (Sen and Bagchi ) and ECV‐304/Jurkat (Yi and others ) co‐cultures. Galangin and luteolin were shown to reduce the differentiation of osteoclasts when co‐cultured with macrophage (Huh and others ) and bone marrow cells (Lee and others ), which helps prevent bone resorption.…”

Section: Co‐culture Models In the Study Of Flavonoid Bioavailability mentioning

confidence: 99%

Review on the Use of Cell Cultures to Study Metabolism, Transport, and Accumulation of Flavonoids: From Mono‐Cultures to Co‐Culture Systems

Gonzales

Camp

Vissenaekens

et al. 2015

Comp Rev Food Sci Food Safe

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The aim of this review is to provide a comprehensive discussion on the various human/animal cell-based models used to study the absorption, transport, and metabolism of flavonoids. Flavonoids are plant-based bioactive compounds that have been extensively investigated for their active role in health alleviation and disease prevention. For this purpose, cell lines isolated from various human and animal tissues have been routinely used as an in vitro model to assess the bioavailability and bioactivity of these compounds. This paper reviews for the first time various transporters (SLCT, SGLT, bilitranslocase, and ABC transporters), metabolic routes (deglycosylation, glucuronidation, sulfation, and deconjugation), and accumulation of flavonoids in different cell lines commonly used in flavonoid research. Also, the use of co-culture systems to study flavonoid bioactivity will be discussed. To date, no definite mono-culture or co-culture formulation has been generally accepted to be the most accurate representation of the in vivo situation. Therefore, further investigation and improvement of cell-based in vitro models for flavonoid research merit further investigation.

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“…Individual plants of the decoction have previously been reported to inhibit (a) COX and lipoxygenase (5-LO) activities in rat peritoneal leukocytes [41], (b) NO production in LPS-induced murine macrophages [42], (c) in vivo and in vitro expression of TNF α in mice bearing concanavalin A-induced liver damages [43] and in Jurkat cells, respectively [44], and (d) NF- κ B activation [45, 46]. However, all these studies used ethanolic extracts of the plant materials and not their aqueous extracts.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised ofNigella sativa(Seeds),Hemidesmus indicus(Root), andSmilax glabra(Rhizome) Mediates Its Antihepatocarcinogenic Effects

Galhena

Samarakoon

Thabrew

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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The present study investigated the anti-inflammatory effects of a polyherbal decoction comprised of Nigella sativa, Hemidesmus indicus, and Smilax glabra in order to justify its claimed antihepatocarcinogenic activity. Activation of hepatic nuclear factor-kappa B (NF-κB), IκB kinase (IKK α/β) proteins, and TNFα and IL-6 expression was investigated in diethylnitrosamine- (DEN-) induced C3H mice-bearing early hepatocarcinogenic changes. Acute phase inflammatory response was evaluated by carrageenan-induced rat paw edema formation. Anti-inflammatory mechanisms were also assessed by determining effect on (a) membrane stabilization, (b) nitric oxide (NO) inhibitory activity, and (c) inhibition of leukocyte migration. A significant inhibition of the paw edema formation was observed in healthy rats as well as in rats bearing early hepatocarcinogenic changes with oral administration of the decoction. As with the positive control, indomethacin (10 mg/kg b.w.) the inhibitory effect was pronounced at 3rd and 4th h after carrageenan injection. A notable IKK α/β mediated hepatic NF-κB inactivation was associated with a significant hepatic TNFα downregulation among mice-bearing hepatocarcinogenic changes subjected to decoction treatment. Inhibition of NO production, leukocyte migration, and membrane stabilization are possible mechanisms by which anti-inflammatory effect is mediated by the decoction. Overall findings imply that anti-inflammatory activity could be one of the mechanisms by which the decoction mediates its antihepatocarcinogenic effects.

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Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-α and its associated MMP-9 activity and CD44 expression

Cited by 28 publications

References 31 publications

Leukemia therapy by flavonoids: Future and involved mechanisms

Leukemia therapy by flavonoids: Future and involved mechanisms

Review on the Use of Cell Cultures to Study Metabolism, Transport, and Accumulation of Flavonoids: From Mono‐Cultures to Co‐Culture Systems

Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised ofNigella sativa(Seeds),Hemidesmus indicus(Root), andSmilax glabra(Rhizome) Mediates Its Antihepatocarcinogenic Effects

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