Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases

Abstract

Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and as critical ingredients for functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from a variety of familiar edible plants, such as the seeds of green tea, Morus alba L., and Cuscuta chinensis. It is noteworthy that AG has a wide range of pharmacological activities and possesses therapeutic effects against a variety of diseases, covering cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory diseases, and reproductive system diseases. This article reviewed the natural source and pharmacokinetics of AG and systematically summarized the pharmacological activities and potential mechanisms of AG in treating diverse diseases in order to promote the development of AG as a functional food, in doing so providing references for its clinical application in disease therapy.

Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin

“…Cynaroside possesses antibacterial, antifungal, antileishmanial, hepatoprotective, antidiabetic, and anticancer properties . Astragalin exerts therapeutic effects against diverse diseases, covering osteoporosis, cancers, mastitis, osteoarthritis, ulcerative colitis, neuropathy, reproductive system diseases, and respiratory diseases …”

“…38 Astragalin exerts therapeutic effects against diverse diseases, covering osteoporosis, cancers, mastitis, osteoarthritis, ulcerative colitis, neuropathy, reproductive system diseases, and respiratory diseases. 39 Health-Promoting Flavonoids in Legumes. There are differences in the physiological effects of flavonoid of various subclasses and in the composition and abundance of flavonoid in diverse legumes.…”

Profiling the Phytochemicals of Orostachys margaritifolia: Biological Activities, LC-ESI/MS, and HPLC Analyses

“…Astragalin has long been utilized for pharmaceutical purposes and is known for its biological functions, such as antioxidant, anti-inflammatory and anticancer activities [ 37 ]. Moreover, it is mentionable that astragalin possesses the potential to alleviate osteoporosis, osteoarthritis, and obesity [ 38 ]. Among seven compounds found in the shrub Thuja orientalis , isoquercitrin was notable for its strong antioxidant activity [ 39 , 40 , 41 , 42 , 43 ].…”

Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury

“…Astragalin (AG) is a flavonoid that occurs naturally and can be extracted from various edible plants, including green tea seeds, Morus alba L., and Cuscuta chinensis . AG has a wide range of pharmacological activities and can be used to treat various diseases, including cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory diseases, and reproductive system diseases ( Chen et al, 2023 ). The expression of PAR-1 and PAR-2 was induced by the model group, and this effect was attenuated by the administration of ≥10 mg/kg astragalin.…”