Astragalin augments basal calcium influx and insulin secretion in rat pancreatic islets

Methyl Caffeate Isolated from the Flowers of Prunus persica (L.) Batsch Enhances Glucose-Stimulated Insulin Secretion

“…Among the isolated compounds, caffeic acid (5), methyl caffeate (6), ferulic acid (7), chlorogenic acid (8), naringenin (11), nicotiflorin (12), and astragalin (13) increased GSIS. Our results are in agreement with previous studies, which showed that caffeic acid (5) [16,17], ferulic acid (7) [18], chlorogenic acid (8), naringenin (11) [17], and astragalin (13) [19] have been reported to increase insulin secretion [20]. Whereas each compound was previously isolated from a different plant, in our study, PRPE with GSIS effect contained all these compounds, with the addition of methyl caffeate (6), chlorogenic acid (8), and nicotiflorin (12), for which no GSIS effect was reported.…”

“…The flowers of P. persica contain phenolic compounds, which in many plants have been reported to possess antidiabetic effects. Caffeic acid [16,17], naringenin [17], ferulic acid [18], astragalin [19], and chlorogenic acid have been reported to increase insulin secretion [20]. It has been reported that methyl caffeate induces pancreatic islet β-cell regeneration [21].…”

Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway

“…Astragalin (ASG) (Figure 1A), also known as kaempferol-3-O-glycosidase, is a natural flavonoid found in various herbs and medicinal plants (Liu et al, 2019), including horseradish tree leaf, lotus leaf, and Chinese rose Oldoni et al, 2019;Li et al, 2020) as well as in some fruits and vegetables such as persimmon (Harikrishnan et al, 2020). Astragalin is used in various pharmacological applications owing to its antiinflammatory, antioxidant, anticancer, bacteriostatic properties, its ability to provide nerve and heart protection, and resistance against and osteoporosis (Rey et al, 2019;Harikrishnan et al, 2020). For instance, astragalin can alleviate acute lung injury caused by lipopolysaccharide-induced inflammation and airway thickening in mice (Soromou et al, 2012;Kim et al, 2017), and it could also delay aging induced by superoxide dismutase and catalase D-galactose in mice .…”

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“…The results of the present study demonstrate that the pain threshold of CCI rats was significantly lower than that of Ctrl rats; in contrast, there was no hyperalgesia in the Sham group, indicating that the neuropathic pain model was successfully established. AST is a compound used in traditional Chinese medicine that has anti-inflammatory and neuroprotective effects (Rey et al, 2019). We found here that MWT and TWL were increased in AST-treated and 5-BDBDtreated CCI rats compared to untreated CCI rats, indicating that P2X4 receptor is involved in pain transmission, and AST can alleviate mechanical and thermal hyperalgesia.…”

“…Chronic constriction injury (CCI) to the sciatic nerve triggers the release of inflammatory factors and induces upregulation of the activated SGC marker glial fibrillary acidic protein (GFAP), which is implicated in the modulation of neuropathic pain (Yuan et al, 2018). Astragalin (AST) is a flavonoid extracted from the white stamen of some flowers with known pharmacologic properties including anti-inflammatory, antioxidant, and anti-allergic activities and protective effects against dermatitis and neuronal injury (Rey et al, 2019). In the present study, we investigated whether AST also has analgesic effects using a rat model of CCI-induced neuropathic pain.…”