Astragaloside IV (AS-IV) alleviates the malignant biological behavior of hepatocellular carcinoma<i>via</i>Wnt/β-catenin signaling pathway

Jiang, Zhongyu; Mao, Zhen

doi:10.1039/c9ra05933d

Cited by 9 publications

(7 citation statements)

References 49 publications

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“…Scholars have found that astragaloside IV has a certain role in the treatment of cancer in multiple parts of the body. Through the Wnt/β-catenin signaling pathway, astragaloside IV reduces the hepatocellular carcinoma's biologically malignant activity [34] and attenuates 3,4-benzo(a)pyrene increased inflammation caused by macrophages, which led to an abdominal aortic aneurysm [35]. Astragaloside IV is able to enhance the sensitivity of some chemotherapy drugs [36][37][38][39][40][41].…”

Section: Application Of Astragaloside IV In Anti-tumormentioning

confidence: 99%

“…The search term: TS = ("astragaloside IV"), and the search was from January 1, 1998, to May 31, 2022, with 1011 records. Invalid documents were excluded, including meeting abstracts (34), editorial materials (1), corrections (4), and letters (1). A total of 971 records were retrieved, which were divided into two document types, 891 articles (91.761%) and 80 reviews (8.239%).…”

Section: Data Collectionmentioning

confidence: 99%

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The state of astragaloside IV research: A bibliometric and visualized analysis

Liu,

Ji,

Liu

et al. 2023

Fundamemntal Clinical Pharma

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BackgroundAstragaloside IV has emerged as a pharmaceutical monomer with great medical applications and potential. Astragaloside IV has many effects such as improving myocardial ischemia, cerebral ischemia–reperfusion injury, anti‐inflammatory, analgesic, antiviral, promoting lymphocyte proliferation, and antitumor effects. However, there are few bibliometric studies on astragaloside IV.ObjectivesWe aim to visualize the hotspots and trends in astragaloside IV research through bibliometric analysis to further understand the future development of basic and clinical research.Methods The articles and reviews on astragaloside IV were screened from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace software. Bibliometric analysis was performed on 971 articles published from 1998 to 2022.ResultsThe number of articles on astragaloside IV increased yearly. These publications came from 42 countries/regions, with China being the largest. The primary research institutions were Shanghai University of Traditional Chinese Medicine and Guangzhou University of Traditional Chinese Medicine. Journal of Ethnopharmacology was the most studied journal and co‐cited journal. A total of 473 authors were included, among which Hongxin Wang had the highest number of publications and Zhang Wd had the highest total citation frequency. After analysis, the most common keywords are astragaloside IV, expression, and oxidative stress. Cardiovascular disease, cerebral ischemia, cancer, and kidney disease are current and developing research fields.ConclusionThis study used bibliometrics and visualization methods to analyze the research hotspots and trends of astragaloside IV. Astragaloside IV on ischemia–reperfusion injury, cancer, and tumor may become the focus of future research.

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Section: Application Of Astragaloside IV In Anti-tumormentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

The state of astragaloside IV research: A bibliometric and visualized analysis

Liu,

Ji,

Liu

et al. 2023

Fundamemntal Clinical Pharma

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“…Astragaloside IV (AS-IV) is a purified natural active component of Astragalus membranaceus, widely used in traditional Chinese medicine [110]. Antioxidant, immunostimulant, and anti-inflammatory properties have been attributed to this plant.…”

Section: Astragaloside IVmentioning

confidence: 99%

Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review

2021

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Burns are a major threat to public health and the economy due to their costly and laborious treatment and high susceptibility to infection. Efforts have been made recently to investigate natural bioactive compounds with potential use in wound healing. The importance lies in the capacities that these compounds could possess both in infection control by common and resistant microorganisms, as well as in the regeneration of the affected tissues, having in both cases low adverse effects. However, some bioactive molecules are chemically unstable, poorly soluble, and susceptible to oxidative degradation or have low bioavailability. Therefore, developing new technologies for an efficient treatment of wound healing poses a real challenge. In this context, electrospun nanofibers have gained increasing research interest because bioactive molecules can be easily loaded within the nanofiber, resulting in optimal burst control and enhanced drug stability. Additionally, the nanofibers can mimic the extracellular collagen matrix, providing a suitable highly porous structural support for growing cells that facilitate and accelerate skin burns healing. This review gives an overview of the current state of electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment.

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“…AS-IV is the main active substance of Astragali Radix, which possesses anticardiovascular disease (Wang Q. N. et al, 2021), liver protection (Liang et al, 2021), antidiabetic nephropathy (Xing et al, 2021), and antitumor activities (Xu et al, 2018). AS-IV exerts antitumor effects on various cancer models, such as lung (Li et al, 2021a), liver (Jiang and Mao, 2019), and colorectal (Ye et al, 2017) carcinomas. In addition, AS-IV can be used in combination with other antitumor drugs and increase the sensitivity of chemotherapy drugs (Zheng et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV, as a potential anticancer agent

Xia

Li²,

Tang

et al. 2023

Front. Pharmacol.

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Cancer is a global intractable disease, and its morbidity and mortality are increasing year by year in developing countries. Surgery and chemotherapy are often used to treat cancer, but they result in unsatisfactory outcomes, such as severe side effects and drug resistance. With the accelerated modernization of traditional Chinese medicine (TCM), an increasing body of evidence has shown that several TCM components have significant anticancer activities. Astragaloside IV (AS-IV) is considered the main active ingredient of the dried root of Astragalus membranaceus. AS-IV exhibits various pharmacological effects, such as anti-inflammatory, hypoglycemic, antifibrotic, and anticancer activities. AS-IV possesses a wide range of activities, such as the modulation of reactive oxygen species-scavenging enzyme activities, participation in cell cycle arrest, induction of apoptosis and autophagy, and suppression of cancer cell proliferation, invasiveness, and metastasis. These effects are involved in the inhibition of different malignant tumors, such as lung, liver, breast, and gastric cancers. This article reviews the bioavailability, anticancer activity, and mechanism of AS-IV and provides suggestions for further research of this TCM.

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Astragaloside IV (AS-IV) alleviates the malignant biological behavior of hepatocellular carcinomaviaWnt/β-catenin signaling pathway

Abstract: Astragaloside IV (AS-IV) is an active substance isolated from Astragalus membranaceus (Fisch.) Bungede, which has been shown to have pharmacological effects in a variety of cancers.

Cited by 9 publications

References 49 publications

The state of astragaloside IV research: A bibliometric and visualized analysis

The state of astragaloside IV research: A bibliometric and visualized analysis

Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review

Astragaloside IV, as a potential anticancer agent

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