Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice

Xu, Nan; Kan, Pengcheng; Yao, Xiuhua; Yang, Ping; Wang, Jiwei; Xiang, Lei; Zhu, Yulan

doi:10.1007/s12275-018-8327-5

Cited by 55 publications

(41 citation statements)

References 29 publications

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“…Traditional Chinese medicine (TCM) has a natural advantage in maintaining cell homeostasis. A variety of TCM compounds or extracted components have been shown to have autophagy regulation function (Gong et al, 2018;Xu et al, 2018a;Li et al, 2019). Shan zhu yu (Cornus officinalis) is one of the most important ingredients in the classic TCM patent prescription "Liuwei Dihuang Wan".…”

Section: Introductionmentioning

confidence: 99%

Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro

et al. 2020

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“…Therefore, it is a critical factor in intestinal disease pathogenesis. ASIV, an active ingredient isolated from Astragalus membranaceus, has demonstrated antioxidative and protective effects on gastrointestinal health [23,24].…”

Section: Discussionmentioning

confidence: 99%

Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling

Wang

Jiang

Cheng

et al. 2019

IJMS

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Oxidative stress can damage intestinal epithelial cell integrity and function, causing gastrointestinal disorders. Astragaloside IV (ASIV) exhibits a variety of biological and pharmacological properties, including anti-inflammatory and antioxidant effects. The purpose of this research was to investigate the cytoprotective action of ASIV and its mechanisms in calf small intestine epithelial cells with hydrogen peroxide (H2O2)-induced oxidative stress. ASIV pretreatment not only increased cell survival, but it also decreased reactive oxygen species generation and apoptosis, enhanced superoxide dismutase, catalase, and glutathione peroxidase levels, and it reduced malondialdehyde formation. Furthermore, pretreatment with ASIV elevated the mRNA and protein levels of nuclear factor erythroid 2-related factor 2 (NFE2L2), heme oxygenase-1 (HMOX1), and NAD(P)H quinone dehydrogenase 1 (NQO1). The NFE2L2 inhibitor ML385 inhibited NFE2L2 expression and then blocked HMOX1 and NQO1 expression. These results demonstrate that ASIV treatment effectively protects against H2O2-induced oxidative damage in calf small intestine epithelial cells through the activation of the NFE2L2-antioxidant response element signaling pathway.

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“…ese beneficial bacteria could prevent pathogenic bacteria from invading. For example, astragaloside can regulate the intestinal microenvironment disorders, increasing the abundance of Bifidobacterium, Brucella, and Clostridium [49], while Ginseng polysaccharide can improve the absorption of ginsenosides and promote the growth of Lactobacillus and Bacteroides [50]. In addition, HM can regulate the intestinal mucosal barrier to prevent bacterial translocation.…”

Section: Gut Microbiota and Herbalmentioning

confidence: 99%

Cross‐Talk between Gut Microbiota and the Heart: A New Target for the Herbal Medicine Treatment of Heart Failure?

Zhong

Cheng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Heart failure (HF) is the severe and terminal stage of various heart diseases. A growing number of studies have suggested the potential clinical significance of gut microbiota in the pathophysiology of HF. Herbal medicine (HM) plays a role in rebalancing the composition of gut microbiota and is widely used in the prevention and treatment of HF. There are many similarities between intestinal microecology and the traditional Chinese medicine (TCM) theory, such as the holistic concept and the theory of the “heart’s connection with the small intestine.” These similarities provide a theoretical basis for HM to prevent and treat diseases by regulating the intestinal flora and its metabolites. In this work, the cross-talk between gut microbiota and the heart is reviewed, and the relationship between TCM and gut microbiota is discussed. Based on the current literature and research, we hypothesize that the cross-talk between gut microbiota and the heart may offer a new therapeutic target for HF intervention.

show abstract

Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice

Cited by 55 publications

References 29 publications

Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro

Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro

Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling

Cross‐Talk between Gut Microbiota and the Heart: A New Target for the Herbal Medicine Treatment of Heart Failure?

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