Astragaloside reduces toxic effect of periodontal ligament fibroblasts induced by lipopolysaccharide

Wu, Caihong; Xia, Lin; Zhou, Bin; Bai, Zhiming; Yuan, Ling; Xu, Dongsheng

doi:10.1016/j.abb.2023.109693

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Periodontitis is an inflammatory disease in which teeth are lost due to the inflamm tion of periodontal tissue and destruction of alveolar bone [3,23]. HPDL cells are fibr blast-like cells with characteristics of collagen production and osteoblasts and are one the main cells of the periodontal ligament involved in the inflammatory process [24,25 Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria such Porphyromonas gingivalis, causes periodontal disease [26]. Lipopolysaccharide (LPS) is complex glycolipid composed of lipid A, a short core oligosaccharide, and an O-antige which can be a long polysaccharide.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Ginsenoside Rg6 in Periodontal Tissue Inflammation and Recovering Damaged Alveolar Bone

Lee,

Kim,

Trang

et al. 2023

Molecules

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Periodontal disease is a chronic disease with a high prevalence, and in order to secure natural materials to prevent oral diseases, new materials that protect periodontal tissue from inflammation are being sought. Genes were identified using real-time quantitative polymerase chain reaction (RT-qPCR), and proteins were confirmed using Western blot. Dichlorodihydrofluorescein diacetate (DCF-DA) analysis was used, and the antibacterial effects were confirmed through Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) analysis. To confirm this effect in vivo, Sprague–Dawley rats, in which periodontitis was induced using ligation or Lipopolysaccharide of Porphyromonas gingivalis (PG-LPS), were used. In vitro experiments using human periodontal ligament (HPDL) cells stimulated with PG-LPS showed that Ginsenoside Rg6 (G-Rg6) had anti-inflammatory, antibacterial, antioxidant, and osteoblast differentiation properties. In vivo, G-Rg6 was effective in Sprague–Dawley rats in which periodontitis was induced using ligation or PG-LPS. Therefore, Ginsenoside Rg6 shows potential effectiveness in alleviating periodontitis.

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