2024
DOI: 10.1002/ptr.8403
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Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway

Gang Kuang,
Yisi Zhao,
Liuyang Wang
et al.

Abstract: Acute hepatic injury (AHI) is associated with poor prognosis in sepsis patient; however, to date, no specific therapeutic approach has been established for this disease. Therefore, we aimed to explore the effects and action mechanisms of Astragaloside IV (AS) on AHI. C57BL/6 mice, RAW264.7 cells, and bone marrow‐derived macrophages were used in this study. Sepsis‐associated AHI model mice were established using lipopolysaccharide + D‐galactosamine. Pathological examination of liver tissues and serum alanine am… Show more

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