Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis by inhibiting polymerase I and transcript release factor and the TLR4/JNK/NF-κB/MyD88 pathway

Sun, Xu; Zheng, Yongri; Xu, Qi-Xiang; Liu, Shuochuan; Li, Huahua; Cheng, Kunming; Yuan, Jianan; Liu, Huaimin; Zhu, Ping

doi:10.1016/j.jep.2023.116662

Cited by 33 publications

(7 citation statements)

References 41 publications

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“…TLR4, which is a recognition receptor of pathogen- and damage-associated molecular patterns, plays an important role in hepatic injury induced by alcohol consumption and fatty liver disease. 32 Elevated LPS in ALD that enters the liver via the portal vein can be recognized by TLR4 on Kupffer cells, which then activates the MyD88-dependent pathway. Subsequently, the classical MyD88-dependent pathway promotes the release of inflammatory cytokines (such as TNF-α, IL-1β and IL-6) by mediating the activation of NF-κB.…”

Section: Discussionmentioning

confidence: 99%

Kluyveromyces marxianus supplementation ameliorates alcohol-induced liver injury associated with the modulation of gut microbiota in mice

Cui,

Guo,

Ning

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Kluyveromyces marxianus supplementation ameliorates alcohol-induced liver injury associated with the modulation of gut microbiota in mice

Cui,

Guo,

Ning

et al. 2023

Food Funct.

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“…Polysaccharides, glycosides, flavonoids, betaine, amino acids, folic acid, carotene, choline, linoleic acid, and other trace elements are some of the main active components of AR [7]. According to modern research, AR has anticancer, anti-inflammatory, and antioxidant properties, blood lipids, and improves immunity [8][9][10][11]. It is reported in the literature that AR is a common drug in the compound prescription for treating T2DM, and it can effectively prevent renal injury caused by T2DM [12][13][14].…”

Section: Results Of α-Glucosidase Inhibitionmentioning

confidence: 99%

Study of the Mechanism of Astragali Radix in Treating Type 2 Diabetes Mellitus and Its Renal Protection Based on Enzyme Activity, Network Pharmacology, and Experimental Verification

Li,

Zhang,

Liu

et al. 2023

Molecules

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Astragali Radix (AR) is a common Chinese medicine and food. This article aims to reveal the active role of AR in treating Type 2 diabetes mellitus (T2DM) and its renal protective mechanism. The hypoglycemic active fraction was screened by α-glucosidase and identified by UPLC-QE-Orbitrap-MS spectrometry. The targets and KEGG pathway were determined through the application of network pharmacology methodology. Molecular docking and molecular dynamics simulation technology were used for virtual verification. Subsequently, a mouse model of T2DM was established, and the blood glucose and renal function indexes of the mice after administration were analyzed to further prove the pharmacodynamic effect and mechanism of AR in the treatment of T2DM. HA was determined as the best hypoglycemic active fraction by the α-glucosidase method, with a total of 23 compounds identified. The main active components, such as calycoside-7-O-β-D-glucoside, methylnisoline, and formononetin, were revealed by network pharmacology. In addition, the core targets and the pathway have also been determined. Molecular docking and molecular dynamics simulation techniques have verified that components and targets can be well combined. In vivo studies have shown that AR can reduce blood sugar levels in model mice, enhance the anti-inflammatory and antioxidant activities of kidney tissue, and alleviate kidney damage in mice. And it also has regulatory effects on proteins such as RAGE, PI3K, and AKT. AR has a good therapeutic effect on T2DM and can repair disease-induced renal injury by regulating the RAGE/PI3K/Akt signaling pathway. This study provides ideas for the development of new drugs or dietary interventions for the treatment of T2DM.

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“…Furthermore, the administration of ZnCM clearly reduces the Cd-loaded local and systemic inflammation that is considered the critical reason for the progression of diabetic nephropathy. Meanwhile, ZnCM inhibited the activation of the inflammation-related TLR4/NF-κB signaling pathway, which is helpful in the alleviation of the progression of diseases ( Sun et al, 2021 ; Sun et al, 2023 ). The development of inflammation is related to zinc deficiency, which induces a decrease in the innate and adaptive immune response ( Bonaventura et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Zn(II)–curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis

Sun,

Mei,

Wang

et al. 2024

Front. Pharmacol.

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Background: Diabetic nephropathy (DN) is known as the most common complication of diabetes, resulting from a complex inheritance-environment interaction without effective clinical treatments. Herein, we revealed the protective effects and mechanisms of Zn(II)-curcumin, a curcumin derivative, against streptozotocin-induced DN in rats in the presence or absence of cadmium exposure.Methods: The present study focused on investigating the therapy of Zn(II)-curcumin against cadmium-aggravated DN by regulating gut microbiota, metabolism, inflammation and zinc homeostasis based on pathological changes, TLR4/NF-κB signaling pathway, inductively coupled plasma-mass spectrometry (ICP-MS), 16S rRNA gene sequencing and gas chromatography-mass spectrometer (GC-MS).Results: We found Zn(II)-curcumin significantly mitigated the cadmium-aggravated phenotypes of diabetic nephropathy, as indicated by the remission of renal dysfunction, pathological changes, inflammation and zinc dyshomeostasis in streptozotocin-treated rats exposed to cadmium. Administration of Zn(II)-curcumin significantly alleviated the dysbiosis of gut microbiota and the changes of serum metabolite profiles in rats treated with streptozotocin in combination with cadmium. Notably, fecal microbial transplantation identified the ability of Zn(II)-curcumin to regulate renal function, inflammation and zinc homeostasis was partly dependent on the gut microbiota.Conclusion: These findings revealed that Zn(II)-curcumin alleviated cadmium-aggravated diabetic nephropathy by reshaping the gut microbiota and zinc homeostasis, which provided unique insights into the mechanisms of the treatment and prevention of diabetic nephropathy.

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Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis by inhibiting polymerase I and transcript release factor and the TLR4/JNK/NF-κB/MyD88 pathway

Cited by 33 publications

References 41 publications

Kluyveromyces marxianus supplementation ameliorates alcohol-induced liver injury associated with the modulation of gut microbiota in mice

Kluyveromyces marxianus supplementation ameliorates alcohol-induced liver injury associated with the modulation of gut microbiota in mice

Study of the Mechanism of Astragali Radix in Treating Type 2 Diabetes Mellitus and Its Renal Protection Based on Enzyme Activity, Network Pharmacology, and Experimental Verification

Zn(II)–curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis

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