Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis

Luan, Aina; Tang, Futian; Yang, Yuhong; Lü, Meili; Wang, Hongxin; Zhang, Yingjie

doi:10.1016/j.etap.2015.03.014

Cited by 45 publications

(30 citation statements)

References 27 publications

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“…The results also showed that in the APS administrated groups HMI and LVMI decreased significantly compared with ISO group, which indicated that the APS had cardiac protective effects. The result is consistent with the previous studies [26].…”

Section: Aps Attenuates Iso Induced Myocardial Hypertrophy In Ratssupporting

confidence: 94%

“…APS was orally administered to animals in many studies and found to be effective in treating many diseases [25,[40][41][42]. We have also previously reported that APS could inhibit ISO-induced cardiac hypertrophy [26,27]. It has also been reported that Astragalus membranaceus and its main components including APS could potently ameliorate endothelial dysfunction induced by homocysteine in which anti-oxidation played a key role [43].…”

Section: Discussionmentioning

confidence: 99%

“…The rats of control group were treated with the same volume of physiological saline (i.p.). The criteria for selection of the doses of APS and ISO in rats were based on the combination of our preliminary experiment and previous report [26,28,29].…”

Section: Experimental Designmentioning

confidence: 99%

“…We have previously reported that APS could inhibit isoproterenol-induced cardiac hypertrophy [26,27]. However, the effects of Astragalus polysaccharide to endothelial dysfunction in hypertrophic rats induced by isoproterenol remains unclear.…”

Section: Introductionmentioning

confidence: 98%

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Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Han

Tang

Lü

et al. 2016

International Immunopharmacology

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Section: Aps Attenuates Iso Induced Myocardial Hypertrophy In Ratssupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Han

Tang

Lü

et al. 2016

International Immunopharmacology

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“…The protein expression of calpain-1, calpain-2, CD68, eNOS and p65 in aorta was examined using Western blot as previously reported method (Luan et al 2015;Tang et al 2016). Nuclear proteins in aortic tissue were separated using Nuclear and Cytoplasm Extraction Kit (Active Motif provided by Dakewe Biotech Limited, China) as previously reported method .…”

Section: Protein Expressions Of Calpain-1 Calpain-2 Cd68 Enos and mentioning

confidence: 99%

Calpain inhibitor I attenuates atherosclerosis and inflammation in atherosclerotic rats through eNOS/NO/NF-κB pathway

Yin

Yang³

et al. 2018

Can. J. Physiol. Pharmacol.

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We previously reported that calpain, the Ca2+-sensitive cysteine protease, gets involved in atherogenesis. This study aimed to investigate the effects of calpain inhibitor I (CAI, 5 mg/kg per day) with or without NG-nitro-l-arginine-methyl ester (l-NAME) (100 mg/kg per day), the inhibitor of nitric oxide synthase (NOS), on atherosclerosis and inflammation in a rat model induced by high-cholesterol diet (HCD). The results demonstrated HCD increased protein expression of calpain-1 but not calpain-2 in aortic tissue. In addition, CAI reduced the thickness of atherosclerotic intima compared with HCD group, which was weakened by the l-NAME combination. CAI with or without l-NAME decreased the activity of calpain in the aorta. Also, CAI decreased the expressions of vascular cell adhesion molecule-1 (VCAM-1), intracellular cell adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1 (MCP-1) in the aorta at the levels of both mRNA and protein. Furthermore, CAI increased the activity and the protein expression of endothelial NOS (eNOS) accompanied by increased content of NO and downregulated the protein expression of nuclear factor κB (NF-κB) of the nucleus in the aorta. However, the abovementioned effects were at least partly cancelled by l-NAME except for the protein expression of eNOS. The results suggested that CAI attenuated atherosclerosis and inflammation through eNOS/NO/NF-κB pathway.

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Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)

Shaker

Kuang

et al. 2021

Medicinal Research Reviews

107

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Huang‐Qi (Astragali Radix) is an herbal tonic widely used in China and many other countries. It is derived from the roots of Astragalus membranaceus and A. membranaceus var. mongholicus and shows potent cardiovascular protective effects. In this article, we comprehensively reviewed 189 small molecules isolated from the two Astragalus species and discussed the interspecies chemical differences. Moreover, we summarized the pharmacological activities and mechanisms of action of Huang‐Qi and its major bioactive compounds for the treatment of cardiovascular diseases. This review covers 171 references published between February 1983 and March 2020.

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Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis

Cited by 45 publications

References 27 publications

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

Calpain inhibitor I attenuates atherosclerosis and inflammation in atherosclerotic rats through eNOS/NO/NF-κB pathway

Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)

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