Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway

Chen, Yanjun; Wang, Jiayu; Li, Juntao; Zhu, Jinghan; Wang, Ruoqin; Xi, Qinhua; Wu, Hongya; Shi, Tongguo; Chen, Weichang

doi:10.1016/j.ejphar.2021.174518

Cited by 102 publications

(62 citation statements)

References 47 publications

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“…The basic features of iron sagging include iron deposition, lipid peroxidation accumulation, GSH depletion, GPX4 inactivation, and LOX upregulation, all of which have been elucidated to be associated with the pathogenesis of UC [ 16 , 46 – 49 ]. Iron chelators have been reported to significantly reduce ROS accumulation, improve clinical symptoms, and promote intestinal epithelial cell repair in UC patients [ 50 , 51 ], and conversely, high dietary iron supplementation can exacerbate UC symptoms [ 52 , 53 ].…”

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

“…Iron chelators have been reported to significantly reduce ROS accumulation, improve clinical symptoms, and promote intestinal epithelial cell repair in UC patients [ 50 , 51 ], and conversely, high dietary iron supplementation can exacerbate UC symptoms [ 52 , 53 ]. Sensitivity to erastin-induced ferroptosis was found in a UC cell model and could be rescued by a ferroptosis specific inhibitor [ 16 , 46 – 49 ]. The ferroptosis phenomenon has also been observed in mouse models of UC and can reduce symptoms by targeted inhibition of ferroptosis [ 16 , 46 – 49 ].…”

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

“…Sensitivity to erastin-induced ferroptosis was found in a UC cell model and could be rescued by a ferroptosis specific inhibitor [ 16 , 46 – 49 ]. The ferroptosis phenomenon has also been observed in mouse models of UC and can reduce symptoms by targeted inhibition of ferroptosis [ 16 , 46 – 49 ]. These findings further validate that inhibition of ferroptosis may be a novel target for alleviating UC.…”

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

“…Nrf2, a major regulator of the antioxidant response, induces the expression of endogenous antioxidant proteins responsible for blocking lipid peroxidation to alleviate OS. Recent studies have demonstrated that Nrf2 can protect UC by inhibiting ferroptosis [ 19 , 46 , 49 , 77 ]. Nrf2 has been reported to be involved in the regulation of ferroptosis by controlling the expression of quinone oxidoreductase 1, iron metabolism proteins, GPX4, and GSH production [ 82 , 83 ].…”

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

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Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics

Huang

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Ulcerative colitis (UC) is a recurrent and persistent nonspecific inflammatory bowel disease (IBD) that greatly affects human survival and social wealth. Despite the advances in the treatment of UC, there is still a high demand for novel therapeutic strategies for UC patients. Cell death is critical to the development and progression of UC. Understanding how intestinal cells die and how to prevent damage to intestinal cells is of great interest for the diagnosis and early treatment of UC. Ferroptosis, a novel form of regulated cell death (RCD) manifested by iron accumulation, lipid peroxidation, and excessive reactive oxygen species (ROS) production, has been shown to contribute to the development and progression of UC. Inhibitors of ferroptosis have been validated in models of UC. Here, we reviewed the mechanisms of initiation and control of ferroptosis and summarize the therapeutic activity of ferroptosis inhibitors in models of UC. We further discussed the possibility of inhibiting ferroptosis as a novel therapeutic target for UC. These findings revealed novel mechanisms to protect the colonic mucosa and highlighted the importance of ferroptosis in the disease process.

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Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

Section: Ferroptosis In Ulcerative Colitismentioning

confidence: 99%

See 2 more Smart Citations

Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics

Huang

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Astragalus polysaccharide (APS) is an active ingredient of Astragalus membranaceus and has been shown to ameliorate experimental colitis-an inflammatory bowel disease (IBD). Chen et al [191] observed that APS administration in experimental colitis mice APS attenuated total weight loss, colon length shortening, histological damage, and the expression of inflammatory cytokines in the colon. Such ameliorations were correlated with ferroptosis inhibition, by the decrease in the expression of ferroptosis-associated genes (PTGS2, FTH, and FTL) and the levels of surrogate ferroptosis markers (Malondialdehyde (MDA), GSH, and iron load).…”

Section: Polysaccharides As Ferroptosis Switchersmentioning

confidence: 99%

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies do not generally exist. Several drugs have been proposed in the last two decades for the treatment of different types of neurodegenerative diseases, with little therapeutic benefit, and often with severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural compounds including polysaccharides have demonstrated neuroprotective and even therapeutic effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and fungal species, and have received considerable attention for their wide-ranging bioactivity, including their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In this review, we summarize different mechanisms involved in neurodegenerative diseases and the neuroprotective effects of natural polysaccharides, highlighting their potential role in the prevention and therapy of neurodegenerative disease.

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Zero‐Valence Selenium‐Enriched Prussian Blue Nanozymes Reconstruct Intestinal Barrier against Inflammatory Bowel Disease via Inhibiting Ferroptosis and T Cells Differentiation

Zhu

Jiang

et al. 2023

Adv Healthcare Materials

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The structural disruption of mechanical barrier and dysfunction of immune barrier in intestinal, are important factors, that aggravate inflammatory bowel disease (IBD). To tackle this challenge, a multifunctional nanozyme capable of scavenging reactive oxygen species (ROS) and inhibiting ferroptosis or T cells differentiation for IBD therapy is here reported. In this work, zero‐valence selenium‐enriched Prussian blue nanozymes (Se‐HMPB nanozymes) are prepared via the hard template method. PB nanozymes with multi‐enzyme activities can effectively scavenge various ROS in inflammatory tissues. Meanwhile, the presence of selenium element endows the glutathione peroxidase activity of Se‐HMPB nanozymes, which can inhibit ferroptosis and reverse the lipid peroxidation of intestinal epithelial cells to protect the intestinal mechanical barrier in ulcerative colitis (UC) model. In addition, selenium supplementation can realize efficient inhibition on the differentiation of T cells in Crohn's disease (CD) model, regulating the intestinal immune barrier. Thus, the Se‐HMPB nanozymes reconstructed intestinal barrier via inhibiting ferroptosis and T cells differentiation in UC and CD models, depicting great potential to alleviate IBD.

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Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway

Cited by 102 publications

References 47 publications

Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics

Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Zero‐Valence Selenium‐Enriched Prussian Blue Nanozymes Reconstruct Intestinal Barrier against Inflammatory Bowel Disease via Inhibiting Ferroptosis and T Cells Differentiation

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