Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases

Elkader, Heba‐Tallah Abd Elrahim Abd; Essawy, Amina E.; Al‐Shami, Ahmed S.

doi:10.1016/j.phytochem.2022.113293

Cited by 33 publications

(16 citation statements)

References 74 publications

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“…In this study, amino acid, terpenoid, and polyketide metabolism were annotated to KEGG, which means that some rhizosphere microbes derived from Astragalus plants could produce such flavonoids and flavonols, lipopolysaccharides, and terpenoids in much higher yields. According to Abd Elrahim Abd Elkader et al [ 10 ], triterpenes, flavonoids, polysaccharides, and amino acids have been identified as the primary functional components of Astragalus . Indeed, in a previous study, flavonoids and terpenoids were isolated from the roots of A. ernestii , which have been used as a substitute for Radix Astragali (Huang-Qi) in southwestern China [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Astragalus , as a group of medicinal plants belonging to the Leguminosae family, are mainly distributed in the high-latitude region, including Inner Mongolia, Shanxi, Gansu, and Heilungkiang provinces of China according to some current records [ 9 ]. The dried root of A. membranaceus is used to tonify the qi and other functions in traditional Chinese medicine [ 10 ]. The Astragalus plants exhibit significant rhizosphere effects referred to as differences in soil biophysical–chemical properties and microbial community composition between rhizosphere soils and bulk soils at the same site [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Microbial Diversity and Community Structure of Rhizosphere Soil of Three Astragalus Species Grown in Special High-Cold Environment of Northwestern Yunnan, China

Ding,

Zhou,

Chen

et al. 2024

Microorganisms

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Astragalus is a medicinal plant with obvious rhizosphere effects. At present, there are many Astragalus plants with high application value but low recognition and resource reserves in the northwestern area of Yunnan province, China. In this study, metagenomics was used to analyze the microbial diversity and community structure of rhizosphere soil of A. forrestii, A. acaulis, and A. ernestii plants grown in a special high-cold environment of northwestern Yunnan, China, at different altitudes ranging from 3225 to 4353 m. These microbes were taxonomically annotated to obtain 24 phyla and 501 genera for A. forrestii, 30 phyla and 504 genera for A. acaulis, as well as 39 phyla and 533 genera for A. ernestii. Overall, the dominant bacterial phyla included Proteobacteria, Actinobacteria, and Acidobacteria, while the dominant fungal ones were Ascomycota and Basidiomycota. At the genus level, Bradyrhizobium, Afipia, and Paraburkholderia were the most prevalent bacteria, and Hyaloscypha, Pseudogymnoascus, and Russula were the dominant fungal genera. Some of them are considered biocontrol microbes that could sustain the growth and health of host Astragalus plants. Redundancy analysis revealed that pH, TN, and SOM had a significant impact on the microbial community structures (p < 0.05). Finally, triterpene, flavonoid, polysaccharide, and amino acid metabolisms accounted for a high proportion of the enriched KEGG pathways, which possibly contributed to the synthesis of bioactive constituents in the Astragalus plants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Microbial Diversity and Community Structure of Rhizosphere Soil of Three Astragalus Species Grown in Special High-Cold Environment of Northwestern Yunnan, China

Ding,

Zhou,

Chen

et al. 2024

Microorganisms

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“…A. mongholicus Bunge is widely distributed in temperate and arid regions. It is an annual or perennial herb, subshrub, or shrub; is usually glabrous, with sharp or hairy stipule and bract margins; is often with minute subsessile glands; and grows in rocky soil [ 26 ]. A. mongholicus Bunge was first recorded in Shennong's Classic of the Materia Medica more than 2000 years ago [ 27 , 28 ].…”

Section: Distribution and Description Of Plantsmentioning

confidence: 99%

Research progress on the mechanism of astragaloside IV in the treatment of asthma

Yuan,

Yang,

Liu

et al. 2023

Heliyon

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“…AR was reported to have a wide range of pharmacological effects, such as immune modulation, anti-oxidation, anti-inflammation, anti-tumorigenesis and anti-myocardial ischemia. Its main active components were water-soluble polysaccharides, isoflavones and saponins ( Abd Elkader et al., 2022 ). In ancient China, AR used was wild Astragalus Radix (WA) ( Zhao et al., 2022 ), but nowadays the resources of WA have been seriously insufficient.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of Astragali Radix with different growth patterns and years, based on a new multidimensional comparison method

Wang,

Yuan,

Zhao

et al. 2024

Front. Plant Sci.

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IntroductionWith the depletion of wild Astragali Radix (WA) resources, imitated-wild Astragali Radix (IWA) and cultivated Astragali Radix (CA) have become the main products of Astragali Radix. However, the quality differences of three growth patterns (WA, IWA, CA) and different growth years of Astragali Radix have not been fully characterized, leading to a lack of necessary scientific evidence for their use as substitutes for WA.MethodsWe innovatively proposed a multidimensional evaluation method that encompassed traits, microstructure, cell wall components, saccharides, and pharmacodynamic compounds, to comprehensively explain the quality variances among different growth patterns and years of Astragali Radix.Results and discussionOur study showed that the quality of IWA and WA was comparatively similar, including evaluation indicators such as apparent color, sectional structure and odor, thickness of phellem, diameter and number of vessels, morphology of phloem and xylem, and the levels and ratios of cellulose, hemicellulose, lignin, sucrose, starch, water-soluble polysaccharides, total-saponins. However, the content of sucrose, starch and sorbose in CA was significantly higher than WA, and the diameter and number of vessels, total-flavonoids content were lower than WA, indicating significant quality differences between CA and WA. Hence, we suggest that IWA should be used as a substitute for WA instead of CA. As for the planting years of IWA, our results indicated that IWA aged 1-32 years could be divided into three stages according to their quality change: rapid growth period (1-5 years), stable growth period (6-20 years), and elderly growth period (25-32 years). Among these, 6-20 years old IWA exhibited consistent multidimensional comparative results, showcasing elevated levels of key active components such as water-soluble polysaccharides, flavonoids, and saponins. Considering both the quality and cultivation expenses of IWA, we recommend a cultivation duration of 6-8 years for growers. In conclusion, we established a novel multidimensional evaluation method to systematically characterize the quality of Astragali Radix, and provided a new scientific perspective for the artificial cultivation and quality assurance of Astragali Radix.

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Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases

Cited by 33 publications

References 74 publications

Analysis of Microbial Diversity and Community Structure of Rhizosphere Soil of Three Astragalus Species Grown in Special High-Cold Environment of Northwestern Yunnan, China

Analysis of Microbial Diversity and Community Structure of Rhizosphere Soil of Three Astragalus Species Grown in Special High-Cold Environment of Northwestern Yunnan, China

Research progress on the mechanism of astragaloside IV in the treatment of asthma

An evaluation of Astragali Radix with different growth patterns and years, based on a new multidimensional comparison method

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