Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder

Attili, Durga; Schill, Daniel J.; DeLong, Cynthia J.; Lim, Katherine; Jiang, Guihua; Campbell, Katherine; Walker, Kendal; Laszczyk, Ann M.; McInnis, Melvin G.; O’Shea, K. Sue

doi:10.1007/978-3-030-45493-7_8

Cited by 11 publications

(9 citation statements)

References 64 publications

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“…To investigate novel approaches for BP patients, iPSCs were generated from the skin samples of BP patients. Attili et al established the iPSC model of BP using exosomes derived from iPSC astrocytes [65].…”

Section: Neurological Diseasementioning

confidence: 99%

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Wang

2021

IJMS

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Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.

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Section: Neurological Diseasementioning

confidence: 99%

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Wang

2021

IJMS

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“…Present studies regarding BD have not specified a cell type, neurotransmitter, or brain region that results in the neuropsychiatric disorder. Alterations in exosome levels are now an area of interest, as they are heavily involved in transport of proteins between cells in the nervous system and cell–cell communication [ 41 ]. Exosomes are a class of extracellular vesicles, which are released by neurons and other cells (including astrocytes) in the CNS and are accessible in the periphery through examination of saliva, urine, and plasma [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Astrocytes in the Neuropathology of Bipolar Disorder: Review of Current Evidence

2022

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(1) Background: Approximately one-third of patients with bipolar disorder (BD) do not experience sustained remission with current treatments. Presently, astrocytes, i.e., glial cells that act as key regulators of neuroinflammation, have been a target for therapeutic development. Research regarding their role in the neuropathology of BD is limited. We conducted a scoping review on evidence linking astrocytes to the pathology of BD. (2) Methods: The search was conducted in MEDLINE for studies published from inception to August 2022. Studies of interest were data-extracted and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. (3) Results: Overall, 650 publications were identified, of which 122 full texts were evaluated and 12 included. Four were in vitro, seven were ex vivo, and one study was both in vitro and in vivo. In vitro investigations focused on plasma levels of neuroinflammatory biomarkers S100B and glial fibrillary acidic protein (GFAP). Ex vivo investigations were post-mortem brain studies assessing astrocytes in regions of interest (i.e., anterior cingulate cortex, dorsolateral prefrontal cortex) using phosphorylated GFAP and ASCT-1. The in vivo and in vitro study evaluated morphological and chemical variations of YKL-40 between cohorts. (4) Conclusions: Reports indicate an association between astrocyte dysfunction and BD although larger studies are required to validate this association.

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“…Soluble cytokines like lipopolysaccharide (LPS), N-methyldopamine, noradrenaline and adiponectin can affect the size and production of exosomes ( Ti et al, 2015 ; Wang et al, 2020 ; Kita and Shimomura, 2021 ). However, the agents may be internalized into exosomes and cause otential physiological hazards ( Attili et al, 2020 ).…”

Section: Biogensismentioning

confidence: 99%

“…To give an example, bipolar I disorder (BP) is a serious recurrent mood disorder characterized by alternating episodes of mania and depression. Attili et al transformed the skin of BP patients into iPSCs, and then established an iPSC model of BP using exosomes derived from iPSC astrocytes ( Attili et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Breakthrough in large-scale production of iPSCs-derived exosomes to promote clinical applications

Chen,

Li,

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder

Cited by 11 publications

References 64 publications

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Astrocytes in the Neuropathology of Bipolar Disorder: Review of Current Evidence

Breakthrough in large-scale production of iPSCs-derived exosomes to promote clinical applications

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