Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development

Xie, Yuliang; Kuan, Aaron T.; Wang, Wengang; Herbert, Zachary T.; Mosto, Olivia; Olukoya, Olubusola; Adam, Manal A; Vu, Steve; Kim, Minsu; Tran, Diana; Gómez, Nicolás; Charpentier, Claire; Sorour, Ingie; Lacey, Tiara E; Tolstorukov, Michael Y.; Sabatini, Bernardo L.; Lee, Wei-Chung Allen; Harwell, Corey C.

doi:10.1016/j.celrep.2022.110416

Cited by 51 publications

(56 citation statements)

References 75 publications

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“…In a seminal study, Farmer and colleagues demonstrated that neurons control Bergmann glia diversity through SHH release in the cerebellum, as well as the acquisition of astrocyte identity in hippocampus [58]. Interestingly, SHH is also produced in adult mouse cortex and SHH receptors are expressed on a proportion of cortical astrocytes [59], an arrangement which appears necessary for the expression of layer-specific astrocyte genes essential for correct synapse development [60,61]. Of course, this does not preclude a contribution of other signaling pathways, such as fibroblast growth factor (FGF) signaling [62].…”

Section: Transcriptome/proteomementioning

confidence: 99%

Astrocyte heterogeneity and interactions with local neural circuits

Holt

2023

Essays in Biochemistry

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Astrocytes are ubiquitous within the central nervous system (CNS). These cells possess many individual processes which extend out into the neuropil, where they interact with a variety of other cell types, including neurons at synapses. Astrocytes are now known to be active players in all aspects of the synaptic life cycle, including synapse formation and elimination, synapse maturation, maintenance of synaptic homeostasis and modulation of synaptic transmission. Traditionally, astrocytes have been studied as a homogeneous group of cells. However, recent studies have uncovered a surprising degree of heterogeneity in their development and function, suggesting that astrocytes may be matched to neurons to support local circuits. Hence, a better understanding of astrocyte heterogeneity and its implications are needed to understand brain function.

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Section: Transcriptome/proteomementioning

confidence: 99%

Astrocyte heterogeneity and interactions with local neural circuits

Holt

2023

Essays in Biochemistry

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“…We observed OXT-neuron-derived Indian hedgehog homolog ligand potentially signalling to glial pituicytes via Cell adhesion molecule-related/down-regulated by oncogenes (Cdon) and Brother of CDO (Boc) receptors. Apart from the role of Hedgehog signalling in midline axonal guidance (Charron and Tessier-Lavigne, 2007; Evans and Bashaw, 2010; Liu and Placzek, 2014), Neuron-derived Hedgehog proteins can regulate astrocyte reactivity and synaptogenesis during mice forebrain development (Chu et al, 2006; Garcia et al, 2010; Xie et al, 2022). It is unknown whether OXT-neuron-derived hedgehog signalling regulates glial pituicytes development and synaptic morphogenesis.…”

Section: Discussionmentioning

confidence: 99%

A ligand-receptor interactome atlas of the zebrafish

Chodkowski

Zieleziński

Anbalagan

2022

Preprint

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Studies in zebrafish can unravel the functions of cellular communication and thus identify novel bench-to-bedside drugs targeting cellular communication signalling molecules. Due to the incomplete annotation of zebrafish proteome, the knowledge of zebrafish receptome, secretome and tools to explore their interactome is limited. To address this gap, we de novo predicted the cellular localization of zebrafish reference proteome using deep learning algorithm. We combined the predicted and existing annotations on cellular localization of zebrafish proteins, and created repositories of zebrafish secretome, receptome, and interactome as well as associated diseases and targeting drugs. Unlike other tools, our interactome atlas is primarily based on physical interaction data of zebrafish proteome. The resources are available as R and Python scripts (https://github.com/DanioTalk). DanioTalk provides a novel resource for researchers interested in targeting cellular communication in zebrafish, as we demonstrate in applications studying synapse and axo-glial interactome.

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“…In addition to their neuron-supportive functions, astrocytes directly alter neuronal communication. They are in contact with tens of thousands of synapses at the tripartite synapse, thereby regulating the functions of presynaptic and postsynaptic terminals and neuronal somas. , A rapidly growing body of literature has revealed that astrocytes play a key role in the response to multiple neuronal diseases. ,, Recent studies have shown that astrocytes, especially SDH astrocytes, are commonly activated in multiple mouse models of dermatitis and contribute to the exacerbation of chronic itch. − …”

Section: Central Glial Cells and Itchmentioning

confidence: 99%

Glial Cells and Itch: Possible Targets for Novel Antipruritic Therapies

Gao

Wang

2023

ACS Chem. Neurosci.

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Glial cells, which are the non-neuronal cells of the nervous system, play essential roles in brain development, homeostasis, and diseases. Glial cells have attracted attention because of their active involvement in many neurological disorders. In recent years, substantial progress has been made in our understanding of the roles of glial cells in the pathogenesis of itch. Mechanistically, central and peripheral glial cells modulate acute and chronic pruritus via different mechanisms. In this review, we present the current knowledge about the involvement of glial cells in the modulation of itch processing and the mechanism of glial cell activation under itch stimuli. Targeting glial cells may provide novel approaches for itch therapy.

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Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development

Cited by 51 publications

References 75 publications

Astrocyte heterogeneity and interactions with local neural circuits

Astrocyte heterogeneity and interactions with local neural circuits

A ligand-receptor interactome atlas of the zebrafish

Glial Cells and Itch: Possible Targets for Novel Antipruritic Therapies

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