Astrocyte responses to nanomaterials: Functional changes, pathological changes and potential applications

Dai, Danni; He, Longwen; Chen, Yuming; Zhang, Chao

doi:10.1016/j.actbio.2020.12.013

Cited by 10 publications

(10 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Astrocytes seeded on nanostructured scaffolds were able to align, following the nanograting axis ( Figure S7 ). An aligned nanotopography has even been ascribed to modulate the reactive response of astrocytes [ 28 ], which could be beneficial for future experiments on neural culture and tissue regeneration.…”

Section: Resultsmentioning

confidence: 99%

Lactide and Ethylene Brassylate-Based Thermoplastic Elastomers and Their Nanocomposites with Carbon Nanotubes: Synthesis, Mechanical Properties and Interaction with Astrocytes

Bello-Álvarez

Etxeberria

Polo³

et al. 2022

Polymers

View full text Add to dashboard Cite

Polylactide (PLA) is among the most commonly used polymers for biomedical applications thanks to its biodegradability and cytocompatibility. However, its inherent stiffness and brittleness are clearly inappropriate for the regeneration of soft tissues (e.g., neural tissue), which demands biomaterials with soft and elastomeric behavior capable of resembling the mechanical properties of the native tissue. In this work, both L- and D,L-lactide were copolymerized with ethylene brassylate, a macrolactone that represents a promising alternative to previously studied comonomers (e.g., caprolactone) due to its natural origin. The resulting copolymers showed an elastomeric behavior characterized by relatively low Young’s modulus, high elongation at break and high strain recovery capacity. The thermoplastic nature of the resulting copolymers allows the incorporation of nanofillers (i.e., carbon nanotubes) that further enable the modulation of their mechanical properties. Additionally, nanostructured scaffolds were easily fabricated through a thermo-pressing process with the aid of a commercially available silicon stamp, providing geometrical cues for the adhesion and elongation of cells representative of the nervous system (i.e., astrocytes). Accordingly, the lactide and ethylene brassylate-based copolymers synthesized herein represent an interesting formulation for the development of polymeric scaffolds intended to be used in the regeneration of soft tissues, thanks to their adjustable mechanical properties, thermoplastic nature and observed cytocompatibility.

show abstract

Section: Resultsmentioning

confidence: 99%

Lactide and Ethylene Brassylate-Based Thermoplastic Elastomers and Their Nanocomposites with Carbon Nanotubes: Synthesis, Mechanical Properties and Interaction with Astrocytes

Bello-Álvarez

Etxeberria

Polo³

et al. 2022

Polymers

View full text Add to dashboard Cite

show abstract

“…The reactive astrocytes can become hypertrophic, hyperplastic, and migratory, contributing to the structural formation of glial scar through the autonomous migration to the injury site and posing divergent effects on neural system regeneration. , The results from the wound healing assay confirmed that SRM1648a-induced reactive astrocytes had a stronger cell migration capability than did the control cells (Figure A,B). Similarly, the promoted cell infiltration and migration were induced in the astrocytes by other exogenous materials, like nanofiber . The chemokines of CCL7, CCL2, and CXCL10 are derived from the reactive astrocytes and involved in directing cell migration and inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the promoted cell infiltration and migration were induced in the astrocytes by other exogenous materials, like nanofiber. 36 The chemokines of CCL7, CCL2, and CXCL10 are derived from the reactive astrocytes 37 and involved in directing cell migration and inflammation. 38 Their transcript upregulation in exposure dose-related manners (Figure 3C) implicated the increase in the recruitment of innate immune cells and facilitation of cell migration.…”

Section: Discussionmentioning

confidence: 99%

AhR Agonistic Components in Urban Particulate Matter Regulate Astrocytic Activation and Function

Zhang,

Pei,

Sun

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Exposure to atmospheric particulate matter (PM) has been found to accelerate the onset of neurological disorders via the induction of detrimental neuroinflammatory responses. To reveal how astrocytes respond to urban atmospheric PM stimulation, a commercially available standard reference material (SRM1648a) was tested in this study on the activation of rat cortical astrocytes. The results showed that SRM1648a stimulation induced both A1 and A2 phenotypes in astrocytes, as characterized by the exposure concentration-dependent increases in Fkbp5, Sphk1, S100a10, and Il6 mRNA levels. Studying the functional alterations of astrocytes indicated that the neurotrophic factors of Gdnf and Ngf were transcriptionally upregulated due to astrocytic A2-type activation. SRM1648a also promoted autonomous motility of astrocytes and elevated the expressions of chemokines. The aryl hydrocarbon receptor (AhR) agonistic components, such as polycyclic aromatic hydrocarbons (PAHs), were recognized to greatly contribute to SRM1648a-induced effects on astrocytes, which was confirmed by the attenuation of PM-disturbed astrocytic effects via AhR blockage. This study, for the first time, uncovered the direct regulation of urban atmospheric PM on astrocytic activation and function and traced the containing bioactive components (e.g., PAHs) with AhR agonistic activity. The findings provided new knowledge on understanding the ambiguous neurological disturbance from ambient fine PM pollution.

show abstract

“…[6][7][8] With the development of nanotechnology, nanomodification has provided new opportunities for optimizing the properties of PUs critical for medical use. [9][10][11][12] On one hand, making use of the small size effect of NMs to combine with PUs could limit the flow of the soft and hard PU segments that regulate physicochemical properties. 13 Since NMs themselves possess excellent thermal conductivity, electrical conductivity, mechanical strength, and considerable stability, their addition further enhances the physicochemical properties of medical PU.…”

Section: Introductionmentioning

confidence: 99%

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

Wang

Dai

Xie

et al. 2022

IJN

Self Cite

View full text Add to dashboard Cite

Polyurethane (PU) has wide application and popularity as medical apparatus due to its unique structural properties relationship. However, there are still some problems with medical PUs, such as a lack of functionality, insufficient long-term implantation safety, undesired stability, etc. With the rapid development of nanotechnology, the nanomodification of medical PU provides new solutions to these clinical problems. The introduction of nanomaterials could optimize the biocompatibility, antibacterial effect, mechanical strength, and degradation of PUs via blending or surface modification, therefore expanding the application range of medical PUs. This review summarizes the current applications of nano-modified medical PUs in diverse fields. Furthermore, the underlying mechanisms in efficiency optimization are analyzed in terms of the enhanced biological and mechanical properties critical for medical use. We also conclude the preparation schemes and related parameters of nano-modified medical PUs, with discussions about the limitations and prospects. This review indicates the current status of nano-modified medical PUs and contributes to inspiring novel and appropriate designing of PUs for desired clinical requirements.

show abstract

Astrocyte responses to nanomaterials: Functional changes, pathological changes and potential applications

Cited by 10 publications

References 183 publications

Lactide and Ethylene Brassylate-Based Thermoplastic Elastomers and Their Nanocomposites with Carbon Nanotubes: Synthesis, Mechanical Properties and Interaction with Astrocytes

Lactide and Ethylene Brassylate-Based Thermoplastic Elastomers and Their Nanocomposites with Carbon Nanotubes: Synthesis, Mechanical Properties and Interaction with Astrocytes

AhR Agonistic Components in Urban Particulate Matter Regulate Astrocytic Activation and Function

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

Contact Info

Product

Resources

About