Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

Nagele, Robert G.; D’Andrea, Michael R.; Lee, H.; Venkataraman, V.; Wang, Hoau Yan

doi:10.1016/s0006-8993(03)02361-8

Cited by 388 publications

(311 citation statements)

References 58 publications

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“…In AD brains, astrocyte accumulation of Aβ 1−42 could result from phagocytosis of degenerated dendrites. Some of these Aβ 1−42 -laden astrocytes could undergo lysis, leading to the formation of astrocyte-derived plaque formation [37]. This phenomenon could help explain the various immunostaining results of astrocytes that we observed.…”

Section: Discussionsupporting

confidence: 51%

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease

Chaudhry

Zhuang

Crain

et al. 2007

Alzheimer's & Dementia

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Section: Discussionsupporting

confidence: 51%

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease

Chaudhry

Zhuang

Crain

et al. 2007

Alzheimer's & Dementia

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“…1); this astrogliosis was observed in both human tissues and in the brains isolated from AD animal models. [147][148][149][150] …”

Section: Astroglia In Alzheimer's Diseasementioning

confidence: 99%

“…Indeed, activated astrocytes located in the close vicinity to A␤ plaques formed in the brains of transgenic APP mice were found to express neprilysin, the amyloid-degrading enzyme. 181 Accumulation of A␤ was observed in astrocytes from entorhinal cortex of AD patients, 147 although it was rarely found in astrocytes from 3xTG-AD mice. 149,150 Functional experiments also demonstrated the ability of astrocytes to phagocyte and degrade ␤-amyloid deposits in an in vitro system.…”

Section: Astroglia and ␤-Amyloidmentioning

confidence: 99%

Astrocytes in Alzheimer's Disease

et al. 2010

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Summary:The circuitry of the human brain is formed by neuronal networks embedded into astroglial syncytia. The astrocytes perform numerous functions, providing for the overall brain homeostasis, assisting in neurogenesis, determining the micro-architecture of the grey matter, and defending the brain through evolutionary conserved astrogliosis programs.Astroglial cells are engaged in neurological diseases by determining the progression and outcome of neuropathological process. Astrocytes are specifically involved in various neurodegenerative diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and various forms of dementia. Recent evidence suggest that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotransmitter homeostasis, and neuronal death through increased excitotoxicity. At the later stages, astrocytes become activated and contribute to the neuroinflammatory component of neurodegeneration.

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“…Astroglial b-amyloid deposits are clearly associated with plaques, as astrocytes positioned away from the plaques show no b-amyloid burden. 54,55 Processes of activated astrocytes were also reported to participate in plaques formation. 54,55 At the very same time astroglial changes during AD progression remain virtually unexplored.…”

Section: Astroglia and Alzheimer's Diseasementioning

confidence: 99%

Astroglia in dementia and Alzheimer's disease

et al. 2008

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Astrocytes, the most numerous cells in the brain, weave the canvas of the grey matter and act as the main element of the homoeostatic system of the brain. They shape the microarchitecture of the brain, form neuronal-glial-vascular units, regulate the blood-brain barrier, control microenvirionment of the central nervous system and defend nervous system against multitude of insults. Here, we overview the pathological potential of astroglia in various forms of dementias, and hypothesise that both atrophy of astroglia and reactive hypertrophic astrogliosis may develop in parallel during neurodegenerative processes resulting in dementia. We also show that in the transgenic model of Alzheimer's disease, reactive hypertrophic astrocytes surround the neuritic plaques, whereas throughout the brain parenchyma astroglial cells undergo atrophy. Astroglial atrophy may account for early changes in synaptic plasticity and cognitive impairments, which develop before gross neurodegenerative alterations.

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Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

Cited by 388 publications

References 58 publications

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease

Astrocytes in Alzheimer's Disease

Astroglia in dementia and Alzheimer's disease

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