Astrocytes and their Phenomenal Possibilities in the Treatment of Various Neurodegenerative Disorders: An Overview

Maslova, Alina Yuryevna; Bazaeva, Kheda Lechaevna; Abdullaeva, Zaira Arazovna; Khazamova, Shuainat Omarovna; Zeusheva, Karina Akhmedovna; Grechkina, Tatiana Alekseevna; Semkina, Evgeniya Nikolaevna; Abramov, Maksim Alekseevich; Mishvelov, Artem Evgenevich; Povetkin, Sergey Nikolaevich

doi:10.9734/jpri/2021/v33i33a31772

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…It was found that the activity of N-acetyltransferase (NAT -N-acetyltransferase) decreases during pregnancy. In some cases, caffeine was used to show that the normal activity of Nacetyltransferase in healthy women decreases during pregnancy [29,30].…”

Section: Resultsmentioning

confidence: 99%

Particular Patterns of the Influence of the Physiology of Normal Pregnancy on the Pharmacokinetics of Drugs in the Liver

Khasueva

Efimova

Khatanova³

et al. 2021

JPRI

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Pregnant women are the most "untouchable" group of people in relation to pharmacological research due to ethical and legal aspects, as well as concerns for the health and integrity of the fetus. And that is why pregnant women practically do not participate in clinical, pharmacodynamic, or pharmacokinetic testing. The mechanisms of teratogenesis are unpredictable, and in this case mutations can occur regardless of the duration of pregnancy and at any level. In women during pregnancy, the activity of liver enzyme systems involved in drug metabolism changes completely, which affects their clearance. This should be taken into account when selecting drugs and dosages for the treatment of various diseases. Our study showed that during pregnancy, a significant decrease in the intrinsic hepatic clearance of the CYP1A2 substrate is enhanced by a decrease in the binding of theophylline to plasma proteins and an increase in the glomerular filtration rate.

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Section: Resultsmentioning

confidence: 99%

Particular Patterns of the Influence of the Physiology of Normal Pregnancy on the Pharmacokinetics of Drugs in the Liver

Khasueva

Efimova

Khatanova³

et al. 2021

JPRI

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“…The analysis of literary and statistical data gives the right to assert that there are no finished products for people of older age groups that correspond to the physiological norms of consumption of basic macro-and micronutrients. In this regard, in order to systematize scientific approaches to meeting the needs of older age groups in basic energy substances, the results of research have been analyzed [4][5][6][7][8][9][10]. It has been established that the optimal, from a scientific point of view, the ratio between the main substances (%) is -proteins: fats : carbohydrates -(16-20) : (25-30) : (55-59).…”

Section: Resultsmentioning

confidence: 99%

“…They determine the importance of the geriatric problem, the negative consequences of which provoke degenerative diseases of the heart, blood vessels, kidneys, digestive organs, musculoskeletal system, including joints and the like [3][4][5][6][7]. Axiomatic is the fact that it is advisable to influence the nature, pace and direction of such changes in metabolism, adaptive and compensatory processes by rationally providing optimal nutrition that will meet the specific needs of natural aging [8,9].…”

Section: Introductionmentioning

confidence: 99%

Development of Scientifically-based Approaches to the Design of Food Products for Herodietic Purposes

Варивода

Kenijz

Dadueva

et al. 2021

JPRI

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The study conducted a detailed analysis and provides data on the demographic situation in the world, as well as in the Russian Federation, concluded that the trend of rapid aging. Nutrition refers to the most important factors of the influence of the external environment on the state of health, working capacity and life expectancy of a person. For this reason, every person needs high-quality and specialized nutrition that will fill all the needs of the body in nutrients, namely proteins, lipids, carbohydrates, vitamins and mineral elements. This scientific article analyzes and systematizes approaches to ensuring the nutritional needs of people of older age groups and recommends ratios in the composition of diets according to gender and age characteristics. The standards of energy and nutritional requirements for various groups of the population are analyzed. The problems associated with the development of the production of products for the elderly are investigated and promising directions of their production are established. It is determined that the most social problem for the elderly is providing the body with biologically and physiologically valuable substances, in particular macro - and microelements, vitamins, essential amino acids, the presence and ratio of which has a significant impact on the processes of metabolism and assimilation by the body.

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“…Gluten sensitivity without celiac disease is another exciting concept. Some patients with irritable bowel syndrome and functional dyspepsia who do not have signs of gluten disease experience a significant improvement in symptoms after excluding gluten from their diet [15,16]. Basic principles of treatment of functional disorder of the gastrointestinal tract in anxiety disorders are showed in Table 1.…”

Section: The Role Of Dietmentioning

confidence: 99%

Possibilities of Correction of Functional Disorders of the Gastrointestinal Tract in Patients with Anxiety Disorders

Volodikhina¹,

Akhmedova²,

Uzdenov³

et al. 2022

Pharmacophore

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Functional disorders of the gastrointestinal tract have recently occupied a niche of the most common diagnoses in gastroenterology, recognized by morphological and physiological abnormalities. Functional disorders of the gastrointestinal tract are a heterogeneous group of disorders, including not only symptoms characteristic of functional dyspepsia (14.6%) in combination with changes in intestinal motility but also irritable bowel syndrome (irritable bowel syndrome, 31.7%) and constipation. These are diseases classified by gastrointestinal manifestations, including one of the following symptoms: impaired motor skills, visceral hypersensitivity, changes in the function of the mucous membrane and the immune system, changes in the intestinal microbiota, and changes in the processing of the central nervous system. According to several studies, mental disorders such as depression and anxiety are often accompanied by functional disorders of the gastrointestinal tract. Thus, it can be concluded that functional disorders of the gastrointestinal tract require a multidisciplinary approach for timely diagnosis and treatment. A recent global Internet survey of the Rome Foundation, in which 127 54 people from 26 countries participated, reported that 32 112 (43%) of the respondents met the criteria for at least one of the manifestations of functional disorders of the gastrointestinal tract. Given the high prevalence of the disease, it is necessary to clearly understand the possibilities of correcting functional disorders of the gastrointestinal tract. This will allow researchers and practitioners to approach the treatment and prevention of this pathology more meaningfully.

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Astrocytes and their Phenomenal Possibilities in the Treatment of Various Neurodegenerative Disorders: An Overview

Cited by 9 publications

References 25 publications

Particular Patterns of the Influence of the Physiology of Normal Pregnancy on the Pharmacokinetics of Drugs in the Liver

Particular Patterns of the Influence of the Physiology of Normal Pregnancy on the Pharmacokinetics of Drugs in the Liver

Development of Scientifically-based Approaches to the Design of Food Products for Herodietic Purposes

Possibilities of Correction of Functional Disorders of the Gastrointestinal Tract in Patients with Anxiety Disorders

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