Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

Bozoyan, Lusiné; Khlghatyan, Jivan; Saghatelyan, Armen

doi:10.1523/jneurosci.5531-11.2012

Cited by 119 publications

(131 citation statements)

References 36 publications

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“…56 RMS astrocytes also interact with blood vessels inside the glial tube and capture BDNF secreted from endothelial cells, which leads to the vasculature-associated migration of neuroblasts in the RMS. 57,58 It was reported that Slit1 and its receptors Robo2/3, which mediate the repellant properties of Slit1, are expressed by migrating neuroblasts in the RMS, suggesting that Slit1 has a cell-autonomous role in the RMS. 59 We showed that Robo2 is strongly expressed by tunnel-forming astrocytes in the RMS.…”

Section: Fig 2 Regulation Of Svz Neurogenesis By Wnt Signalingmentioning

confidence: 99%

Mechanisms of Neurogenesis in the Normal and Injured Adult Brain

Sawada

Sawamoto

2013

Keio J. Med.

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Even in the adult brain, new neurons are continuously generated from endogenous neural stem cells that reside in two restricted regions: the subventricular zone (SVZ) of the lateral ventricle and the dentate gyrus of the hippocampus. These new neurons are integrated into the mature neuronal circuitry and become involved in various functions, thereby contributing to structural and functional plasticity in the adult brain. In this review, we summarize our recent findings on the regulatory mechanisms of SVZ neurogenesis under physiological and pathological conditions in various animal models. Some of these findings were presented in the Kitazato Prize Lecture at Keio University School of Medicine in

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Section: Fig 2 Regulation Of Svz Neurogenesis By Wnt Signalingmentioning

confidence: 99%

Mechanisms of Neurogenesis in the Normal and Injured Adult Brain

Sawada

Sawamoto

2013

Keio J. Med.

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“…For the normal development and maintenance of the brain, neurons must migrate at the proper speed along their path and stop upon reaching their destination. Normally, the speed of neuronal migration is not constant, it can be affected by brain development and by the microenvironments surrounding neurons 5 . To control speed tightly, both acceleration and braking systems may be needed.…”

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confidence: 99%

Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA

et al. 2014

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“…Data are expressed as meanGS.E.M., nZ4, **P!0.01 and ***P!0.001 vs the control by unpaired Student's t-test. developing brain (Bozoyan et al 2012) and retina (Gerhardt et al 2003, Scott et al 2010. Proliferation of endothelial cells is mainly regulated by the signaling of VEGFA and VEGFR2 in the developing vasculature (Gerhardt et al 2003, Somanath et al 2009).…”

Section: Continuous Angiogenesismentioning

confidence: 99%

VEGF-dependent and PDGF-dependent dynamic neurovascular reconstruction in the neurohypophysis of adult mice

Furube¹,

Mannari²,

Morita³

et al. 2014

Journal of Endocrinology

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Hypothalamo-neurohypophysial system (HNS) releases arginine vasopressin (AVP) and oxytocin (OXT) from axonal terminals of the neurohypophysis (NH) into blood circulation for controlling body fluid homeostasis and lactation. Chronic osmotic and suckling stimulations have been shown to cause neurovascular and neuroglial reconstruction in the NH of adult mammals and no study has been reported for vascular dynamics. The aim of this study was to elucidate the occurrence of continuous angiogenesis and growth factor-dependent neurovascular reconstruction in the NH of adult mice. Active proliferation of endothelial cells and oligodendrocyte progenitor cells (OPCs) was observed using the immunohistochemistry of bromodeoxyuridine and Ki-67. Vascular endothelial growth factor A (VEGFA) and VEGF receptor 2 (VEGFR2 (KDR)) were highly expressed at pituicytes and endothelial cells respectively. Moreover, prominent expression of platelet-derived growth factor B (PDGFB) and PDGF receptor beta was observed at OXT-containing axonal terminals and pericytes respectively. Administration of the selective tyrosine kinase inhibitor AZD2171 for VEGFRs and STI571 for PDGFRs significantly decreased proliferation of endothelial cells and OPCs. Moreover, AZD2171 treatment decreased vascular density by facilitating apoptosis of endothelial cells and the withdrawal of its treatment led to remarkable rebound proliferation of endothelial cells, so that vascular density rapidly returned to normal levels. AZD2171 decreased the density of both AVP-and OXT-containing axonal terminals, whereas STI571 selectively decreased the density of AVP-containing ones. Thus, this study demonstrates that the signaling pathways of VEGF and PDGF are crucial mediators for determining proliferation of endothelial cells and OPCs and the density of AVP-and OXT-containing axonal terminals in the HNS.

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Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

Cited by 119 publications

References 36 publications

Mechanisms of Neurogenesis in the Normal and Injured Adult Brain

Mechanisms of Neurogenesis in the Normal and Injured Adult Brain

Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA

VEGF-dependent and PDGF-dependent dynamic neurovascular reconstruction in the neurohypophysis of adult mice

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