Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Wahis, Jérôme; Baudon, Angel; Althammer, Ferdinand; Kerspern, Damien; Goyon, Stéphanie; Hagiwara, Daisuke; Lefèvre, Arthur; Barteczko, Lara; Boury-Jamot, Benjamin; Bellanger, Benjamin; Abatis, Marios; Gouveia, Miriam da Silva; Benusiglio, Diego; Eliava, Marina; Rozov, Andrei; Weinsanto, Ivan; Knobloch‐Bollmann, H. Sophie; Kirchner, Matthew K.; Roy, Ranjan K.; Wang, Hong; Pertin, Marie; Inquimbert, Perrine; Pitzer, Claudia; Siemens, Jan; Goumon, Yannick; Boutrel, Benjamin; Lamy, Christophe; Décosterd, Isabelle; Chatton, Jean–Yves; Rouach, Nathalie; Young, W. Scott; Stern, Javier E.; Poisbeau, Pierrick; Stoop, Ron; Darbon, Pascal; Grinevich, Valery; Charlet, Alexandre

doi:10.1038/s41593-021-00800-0

Cited by 119 publications

(179 citation statements)

References 71 publications

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“…Somatodendritic release of AVP and OXT has important autocrine effects in MCNs and paracrine effects in nearby cells regulating a variety of functions such as the blood pressure 69 or the milk‐ejection reflex 70 . In addition, MCNs from the SON and PVN also send extra‐neurohypophyseal collateral projections to other brain areas contributing to central actions and affecting complex outputs, such as regulating pain perception, 71 affective/emotional states, 72,73 social behaviour, 74,75 fear, 76,77 and general anaesthesia and sleep 78 . It will be of great interest to identify individual MCN transcriptome signatures that mediate to these diverse physiological and behavioural roles.…”

Section: Study Limitationsmentioning

confidence: 99%

Osmoregulation of the transcriptome of the hypothalamic supraoptic nucleus: A resource for the community

Pauža

Mecawi

Paterson

et al. 2021

J Neuroendocrinology

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The hypothalamic supraoptic nucleus (SON) is a core osmoregulatory control centre that deciphers information about the metabolic state of the organism and orchestrates appropriate homeostatic (endocrine) and allostatic (behavioural) responses. We have used RNA sequencing to describe the polyadenylated transcriptome of the SON of the male Wistar Han rat. These data have been mined to generate comprehensive catalogues of functional classes of genes (enzymes, transcription factors, endogenous peptides, G protein coupled receptors, transporters, catalytic receptors, channels and other pharmacological targets) expressed in this nucleus in the euhydrated state, and that together form the basal substrate for its physiological interactions. We have gone on to show that fluid deprivation for 3 days (dehydration) results in changes in the expression levels of 2247 RNA transcripts, which have similarly been functionally catalogued, and further mined to describe enriched gene categories and putative regulatory networks (Regulons) that may have physiological importance in SON function related plasticity. We hope that the revelation of these genes, pathways and networks, most of which have no characterised roles in the SON, will encourage the neuroendocrine community to pursue new investigations into the new ‘known‐unknowns’ reported in the present study.

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Section: Study Limitationsmentioning

confidence: 99%

Osmoregulation of the transcriptome of the hypothalamic supraoptic nucleus: A resource for the community

Pauža

Mecawi

Paterson

et al. 2021

J Neuroendocrinology

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“…In various subcortical regions innervated by OT axons, the neuropeptide release is known to attenuate anxiety, fear, and physiological stress responses. Specifically, OT modulation of neural circuits in the central amygdala reduces contextual fear response (Knobloch et al, 2012;Hasan et al, 2019) and anxiety (Wahis et al, 2021), and in the lateral septum (LS) prevents social fear during lactation (Menon et al, 2018) as well as decreases aggression of female virgins (Oliveira et al, 2020). OT axons also reach the paraventricular nucleus of the thalamus (PVT) promoting maternal behavior (Knobloch et al, 2012;Cilz et al, 2018;Watarai et al, 2020).…”

Section: Brain-wide Ot Modulationmentioning

confidence: 99%

“…Although OTR neurons are present in the vast majority of forebrain regions, the anatomical and functional connectivity between them has only been explored by a few studies. While the dominating view is that OTR neurons generally represent GABAergic local interneurons (Marlin and Froemke, 2016 ), it is now known that principal glutamatergic neurons, as well as astrocytes, are also capable to express OTR (Mitre et al, 2016 ; Tan et al, 2019 ; Wahis et al, 2021 ).…”

Section: Do Otr Neurons In Distant Brain Regions Communicate To Each Other?mentioning

confidence: 99%

Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors

Lefèvre

Benusiglio

Tang

et al. 2021

Front. Neural Circuits

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Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT.

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“…The amygdala mediates both conditioned and unconditioned memory of stressful events, so its activity increases during recollection. Studies using functional magnetic resonance imaging (fMRI) have shown an increase in spontaneous amygdala activity, as well as amygdala activity, when recalling traumatic events [229]. This explains why people suffering from PTSD have hippocampal atrophy without change in amygdala volume.…”

Section: Post-traumatic Stress Disordermentioning

confidence: 99%

Understanding Emotions: Origins and Roles of the Amygdala

et al. 2021

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Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. Feelings are conscious, emotional experiences of these activations that contribute to neuronal networks mediating thoughts, language, and behavior, thus enhancing the ability to predict, learn, and reappraise stimuli and situations in the environment based on previous experiences. Contemporary theories of emotion converge around the key role of the amygdala as the central subcortical emotional brain structure that constantly evaluates and integrates a variety of sensory information from the surroundings and assigns them appropriate values of emotional dimensions, such as valence, intensity, and approachability. The amygdala participates in the regulation of autonomic and endocrine functions, decision-making and adaptations of instinctive and motivational behaviors to changes in the environment through implicit associative learning, changes in short- and long-term synaptic plasticity, and activation of the fight-or-flight response via efferent projections from its central nucleus to cortical and subcortical structures.

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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Cited by 119 publications

References 71 publications

Osmoregulation of the transcriptome of the hypothalamic supraoptic nucleus: A resource for the community

Osmoregulation of the transcriptome of the hypothalamic supraoptic nucleus: A resource for the community

Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors

Understanding Emotions: Origins and Roles of the Amygdala

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