Astrocytic contribution to glutamate-related central respiratory chemoreception in vertebrates

Olivares, María José; Flores, A.; Bernhardi, Rommy von; Eugenı́n, Jaime

doi:10.1016/j.resp.2021.103744

Cited by 5 publications

(4 citation statements)

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“…Further studies are needed to determine how Epo might modulate RTN chemosensitivity. Paracrine stimulation of RTN/pFRG neurons by astrocytes having CO 2 /H + -sensing properties has also been implicated in the RTN/pFRG neuron activation under hypercapnia ( Gourine et al, 2010 ; Olivares et al, 2021 ). Thus, a possible explanation would be that Epo deficiency affects the coupling between astrocytes and neurons in this medullary area.…”

Section: Discussionmentioning

confidence: 99%

“…Astrocytes, a well-known source of Epo, are involved in the modulation of neighbouring neurons at the RTN/pFRG place ( Marti et al, 1996 ; Gourine et al, 2010 ; Olivares et al, 2021 ). To determine if the RTN/pFRG hypercapnic c-FOS-positive cells were astrocytes, double labelling c-FOS and GFAP was performed.…”

Section: Methodsmentioning

confidence: 99%

“…These observations can be related to the presence of EpoR in the main peripheral and central respiratory areas that regulate breathing ( Soliz et al, 2005 ). On the basis of these data, and keeping in mind that the CO 2 /H + regulation of breathing mainly depends on brainstem structures ( Feldman et al, 2003 ; Guyenet et al, 2005 , 2019 ; Nattie and Li, 2006a ; Guyenet and Bayliss, 2015 ; Olivares et al, 2021 ), recent studies have aimed to determine if Epo modulates the hypercapnic ventilatory response to CO 2 (HcVR). Searching for an influence of Epo in HcVR is relevant because the central CO 2 /H + chemosensitivity is essential.…”

Section: Introductionmentioning

confidence: 99%

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In Transgenic Erythropoietin Deficient Mice, an Increase in Respiratory Response to Hypercapnia Parallels Abnormal Distribution of CO2/H+-Activated Cells in the Medulla Oblongata

et al. 2022

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Erythropoietin (Epo) and its receptor are expressed in central respiratory areas. We hypothesized that chronic Epo deficiency alters functioning of central respiratory areas and thus the respiratory adaptation to hypercapnia. The hypercapnic ventilatory response (HcVR) was evaluated by whole body plethysmography in wild type (WT) and Epo deficient (Epo-TAgh) adult male mice under 4%CO2. Epo-TAgh mice showed a larger HcVR than WT mice because of an increase in both respiratory frequency and tidal volume, whereas WT mice only increased their tidal volume. A functional histological approach revealed changes in CO2/H+-activated cells between Epo-TAgh and WT mice. First, Epo-TAgh mice showed a smaller increase under hypercapnia in c-FOS-positive number of cells in the retrotrapezoid nucleus/parafacial respiratory group than WT, and this, independently of changes in the number of PHOX2B-expressing cells. Second, we did not observe in Epo-TAgh mice the hypercapnic increase in c-FOS-positive number of cells in the nucleus of the solitary tract present in WT mice. Finally, whereas hypercapnia did not induce an increase in the c-FOS-positive number of cells in medullary raphe nuclei in WT mice, chronic Epo deficiency leads to raphe pallidus and magnus nuclei activation by hyperacpnia, with a significant part of c-FOS positive cells displaying an immunoreactivity for serotonin in the raphe pallidus nucleus. All of these results suggest that chronic Epo-deficiency affects both the pattern of ventilatory response to hypercapnia and associated medullary respiratory network at adult stage with an increase in the sensitivity of 5-HT and non-5-HT neurons of the raphe medullary nuclei leading to stimulation of fR for moderate level of CO2.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Transgenic Erythropoietin Deficient Mice, an Increase in Respiratory Response to Hypercapnia Parallels Abnormal Distribution of CO2/H+-Activated Cells in the Medulla Oblongata

et al. 2022

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“…Известно, что нейроны РТЯ имеют возбуждающие проекции в ростральный и каудальный отделы вентральной респираторной группы, понтинную респираторную группу, а также в комплексы Бетцингера и пре-Бетцингера [5], отвечающие за респираторный ритмогенез. Синаптические контакты РТЯ оказывают модулирующие влияния на процессы регуляции ритма и паттерна дыхания, благодаря множеству нейромедиаторных веществ, включая ГАМК [13], глутамат [10], серотонин [6], АТФ [7] и др. Среди перечисленных нейромедиаций до сих пор недостаточно изученными остаются роль и рецепторные механизмы участия ГАМК в формировании респираторных реакций на уровне РТЯ.…”

Section: Respiratory Responses To Microinjections Of Baclofen and 2-h...unclassified

Реакции Дыхания На Микроинъекции Баклофена И 2-Гидроксисаклофена В Ретротрапециевидное Ядро У Крыс

Будаев¹,

Конашенкова²,

Ведясова³

et al. 2022

Современная Нейробиология: Фундаментальные Исследования И Практические Аспекты

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Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water

Paley

2023

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

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Astrocytic contribution to glutamate-related central respiratory chemoreception in vertebrates

Cited by 5 publications

References 254 publications

In Transgenic Erythropoietin Deficient Mice, an Increase in Respiratory Response to Hypercapnia Parallels Abnormal Distribution of CO2/H+-Activated Cells in the Medulla Oblongata

In Transgenic Erythropoietin Deficient Mice, an Increase in Respiratory Response to Hypercapnia Parallels Abnormal Distribution of CO2/H+-Activated Cells in the Medulla Oblongata

Реакции Дыхания На Микроинъекции Баклофена И 2-Гидроксисаклофена В Ретротрапециевидное Ядро У Крыс

Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water

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