Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice

Jia, Yun Fang; Wininger, Katheryn; Ho, Ayy; Peyton, Lee; Baker, Matthew B.; Choi, Doo Sup

doi:10.3389/fnbeh.2020.00057

Cited by 25 publications

(16 citation statements)

References 47 publications

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“…That should not be very surprising knowing that GLT-1 accounts for more than 90% of glutamate uptake in the brain. These findings were recently confirmed by another research group [ 78 , 79 ]. Furthermore, postnatal disturbance of glia proliferation may lead to hyperactive behaviour in open field tests and alterations of social interactions in rats [ 80 ].…”

Section: Astrocytes As Important Players In the Cnssupporting

confidence: 75%

Astroglia in Autism Spectrum Disorder

Gzieło

Nikiforuk

2021

IJMS

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Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of different intensity and may vary in types. Risk factors for ASD include disturbed brain homeostasis, genetic predispositions, or inflammation during the prenatal period caused by viruses or bacteria. The number of diagnosed cases is growing, but the main cause and mechanism leading to ASD is still uncertain. Recent findings from animal models and human cases highlight the contribution of glia to the ASD pathophysiology. It is known that glia cells are not only “gluing” neurons together but are key players participating in different processes crucial for proper brain functioning, including neurogenesis, synaptogenesis, inflammation, myelination, proper glutamate processing and many others. Despite the prerequisites for the involvement of glia in the processes related to the onset of autism, there are far too little data regarding the engagement of these cells in the development of ASD.

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Section: Astrocytes As Important Players In the Cnssupporting

confidence: 75%

Astroglia in Autism Spectrum Disorder

Gzieło

Nikiforuk

2021

IJMS

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“…From a biological standpoint, one of the explanations for the high effectiveness of saffron in combination with MPH is its effect on monoaminergic and glutamatergic systems. Chemical compounds of saffron can improve mood and modulate brain function through monoaminergic and glutamatergic systems (45)(46)(47)(48). Furthermore, due to the pathophysiology of ADHD and the involvement of various mechanisms, such as reduced and fluctuated brain volume in some brain areas (prefrontal cortex, cerebellum, and basal ganglia), it seems that these regions are directly involved in ADHD emergence (49).…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Methylphenidate (MPH) and Combined Methylphenidate with Crocus sativus (Saffron) in the Treatment of Children and Adolescents with ADHD: A Randomized, Double-blind, Parallel-Group, Clinical Trial

Khaksarian

Ahangari

Masjedi-Arani

et al. 2021

Iran J Psychiatry Behav Sci

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Background: Attention-deficit/hyperactivity disorder (ADHD) is characterized by behavioral and neurodevelopmental problems. It is estimated that 3 - 7% of children and adolescents suffer from this problem. Apart from synthetic drugs, other effective types of medication like herbal medicines are of great importance. Objectives: This study aimed to evaluate the effectiveness of methylphenidate (MPH) and its combination with Crocus sativus (saffron) in the treatment of children suffering from ADHD. Methods: The sample included 70 children aged between 6 and 16 years who had been diagnosed with ADHD. The patients were randomly assigned into two equal groups (n = 35 in each group). While both groups received 20 or 30 mg/d of MPH (20 and 30 mg/d for < 30 and > 30, respectively), one of them also received 20 or 30 mg/d of saffron in a capsule based on BMI (20 and 30 mg/d for < 30 and > 30, respectively). To collect data, parents and teachers completed Attention-Deficit/Hyperactivity Disorder Rating Scale-IV (ADHD-RS-IV). Also, for analyzing the data, the repeated measures analysis of variance (RMANOVA) was used. Results: The results of general linear model (GLM) repeated measures indicated that in both groups, the patients had less symptoms after eight weeks of treatment. However, after four weeks, the average score assigned by the parents and teachers in the MPH with saffron group was lower than the average total score in the MPH group (P < 0.05). Conclusions: Using MPH combined with saffron proved to be more effective in the treatment of patients suffering from ADHD compared to separate treatments. It seems that the duration of therapy can be reduced and the effectiveness be improved by prescribing proposed combined treatment.

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“…For instance, reduced astrocytic EAAT2 correlated with chronic social defeat stress in a rat depression model (Rappeneau et al, 2016). Another example examined mice deficient in astrocytic EAAT2 and uncovered that these mice exhibited less anxiety and depression-related behavior (Jia et al, 2020). Relating to sexual behavior, researchers tested the effects of glutamate transporter inhibitors on the male sexual behavior of Long-Evans rats (Dominguez et al, 2006).…”

Section: Glutamate Transporters and Rodent Male Sexual Behaviormentioning

confidence: 99%

Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence

Chiang

Park

2020

Front. Behav. Neurosci.

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The survival of animal species predicates on the success of sexual reproduction. Neurotransmitters play an integral role in the expression of these sexual behaviors in the brain. Here, we review the role of glutamate in sexual behavior in rodents and non-rodent species for both males and females. These encompass the release of glutamate and correlations with glutamate receptor expression during sexual behavior. We then present the effects of glutamate on sexual behavior, as well as the effects of antagonists and agonists on different glutamate transporters and receptors. Following that, we discuss the potential role of glutamate on steroid-independent sexual behavior. Finally, we demonstrate the interaction of glutamate with other neurotransmitters to impact sexual behavior. These sexual behavior studies are crucial in the development of novel treatments of sexual dysfunction and in furthering our understanding of the complexity of sexual diversity. In the past decade, we have witnessed the burgeoning of novel techniques to study and manipulate neuron activity, to decode molecular events at the single-cell level, and to analyze behavioral data. They pose exciting avenues to gain further insight into future sexual behavior research. Taken together, this work conveys the essential role of glutamate in sexual behavior.

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Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice

Cited by 25 publications

References 47 publications

Astroglia in Autism Spectrum Disorder

Astroglia in Autism Spectrum Disorder

A Comparison of Methylphenidate (MPH) and Combined Methylphenidate with Crocus sativus (Saffron) in the Treatment of Children and Adolescents with ADHD: A Randomized, Double-blind, Parallel-Group, Clinical Trial

Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence

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