The third Antarctic Survey Telescope array instrument at Dome A in Antarctica, the AST3-3 telescope, has been in commissioning from March 2021. We deployed AST3-3 at the Yaoan astronomical station in Yunnan Province for an automatic time-domain survey and follow-up observations with an optimised observation and protection system. The telescope system of AST3-3 is similar to that of AST3-1 and AST3-2, except that it is equipped with a 14 K × 10 K QHY411 CMOS camera. AST3-3 has a field of view of 1.65∘×1.23∘ and is currently using the g band filter. During commissioning at Yaoan, AST3-3 aims to conduct an extragalactic transient survey, coupled with prompt follow-ups of opportunity targets. In this paper, we present the architecture of the AST3-3 automatic observation system. We demonstrate the data processing of observations by representatives SN 2022eyw and GRB 210420B.