“…Among, 1,3,4-thiadiazoles having more applications and exhibiting potential biological activities like insecticidal 8,9 , fungicidal 10,11 ,herbicidal activity 12 , potent anti-cancer 13,14 ,anti-proliferative activity 15,16 , Antiviral 17 , inhibitors of acetyl cholinesterase (AChE) and butyrylcholinesterase (BuChE) 18 , Alzheimer 19,20 , and antimicrobial activities 21 . 1,3,4-thiadiazoles also used in electrical and optical 22 , liquid crystal [24][25][26] , corrosion inhibitors 27 , in dye preparation 28 . The literature survey reveals that various thiadiazoles are the part of many potential drugs ( Fig.…”