Asymmetric Alkylation of Dimethoxyphosphoryl‐N‐[1‐(S)‐α‐methylbenzyl]acetamide Enolates. Synthesis of Both Stereoisomers from the Same Source of Chirality by Changing the Equivalents of LDA.

Abstract

Organo-phosphorus compounds S 0080 Asymmetric Alkylation of Dimethoxyphosphoryl-N-[1-(S)-α-methylbenzyl]acetamide Enolates. Synthesis of Both Stereoisomers from the Same Source of Chirality byChanging the Equivalents of LDA. -A novel method for the preparation of both diastereomers of α,α-disubstituted β-phosphonamides by changing the amount of LDA in the alkylation reaction is described. -(ORDONEZ*, M.; HERNANDEZ-FERNANDEZ, E.; XAHUENTITLA, J.; CATIVIELA, C.; Chem. Commun. (Cambridge) 2005, 10, 1336-1338; Cent. Invest. Quim., Univ. Auton. Estado Morelos, 62210 Cuernavaca, Mex.; Eng.) -M. Paetzel 30-160