Asymmetric and symmetric dimethylarginine gingival crevicular fluid levels in periodontitis

Abstract

Periodontitis is a chronic, progressive inflammatory disease with damage of the periodontium that can lead to tooth loss. 1 Disease features involve the activation of inflammatory cells such as PMNLs, macrophages, T and B cells 2 and, therefore, the expression of mediators such as cytokines, 2 prostaglandins, 3 acute phase reactants, 4 and nitric oxide (NO). 2 Nitric oxide, synthesized from l-arginine by nitric oxide synthase (NOS), is a free radical that is involved in a multitude of physiological

Impact of Inflammatory Markers and Senescence-Associated Secretory Phenotype in the Gingival Crevicular Fluid on the Outcomes of Periodontal Regeneration

“…Notably, statistically significant positive associations were established between pre-surgical levels of IL-1β, MMP-8, and -9 in the GCF and clinical and radiographic parameters at the 12-month follow-up. These observations are in agreement with what is biologically reasonable to expect since these molecules are widely recognized as inflammatory mediators, acting as key active players in the etiopathogenetic process of periodontitis [ 34 ]. Specifically, IL-1β and IL-6 are the principal pro-inflammatory cytokines which contribute to the immune T-helper 17 mediated dysregulated response underlying periodontitis pathogenesis [ 35 ].…”