Asymmetric Biginelli Reaction Catalyzed by Silicon, Titanium and Aluminum Oxides

Recent Advances in Homogeneous and Heterogeneous Catalyst in Biginelli Reaction from 2015‐19: A Concise Review

“…Asymmetric Biginelli reaction was performed by using chiral inductor in the presence of metal oxides . The model reaction carried out between 1 (0.47 mmol ), 3 (1.41 mmol) and 5 (0.7 mmol ) in the presence of chiral inductor (0.047 mmol ) and metal oxide (0.047 mmol) in THF at 23 °C for 45 h as represented in the Scheme .…”

Synthesis of 3,4-Dihydropyrimidine-2-(1H)- Ones/Thiones Catalyzed by Ionic Liquid [C₂O₂BBTA][TFA]

“…众所周知，3,4-二氢嘧啶-2(1H)-酮/硫酮化合物具有抗过敏、降压、杀菌、消炎、抗病毒 [1]- [6]及抑制 有丝分裂驱动蛋白 [7] [8]等重要的药理和生物活性。100 多年前，意大利化学家 Biginelli 首次提出了浓盐 酸催化苯甲醛、尿素和乙酰乙酸乙酯三组分反应合成 3,4-二氢嘧啶-2(1H)-酮/硫酮的方法 [9]。然而该方法 存在条件苛刻、反应时间长(18 h)且产率低(20%~50%)的缺点。因此，各种催化体系被用于该反应以改进 经典方法的不足，如多组分聚合物 1,4-DHP 和 3,4-DHPM [10]、纳米共催化剂 TiO 2 -SiO 2 [11]、Cu-EDTA 负载的 APTMS-Fe 3 O 4 @SiO 2 核-壳体系 [12]、硅钛铝氧化物 MxOy [13]、微波促进 [14]等。 离子液体因具有蒸气压低、热稳定性好、毒性低、易于回收等诸多优点，在 Biginelli 反应中也得到 了应用 [15] [16]。基于本课题组在离子液体合成和催化应用领域的研究基础 [17]…”

Effect of the Exchanged Cation in an Algerian Montmorillonite Used as a Heterogeneous Catalyst for Biginelli Reaction

“…27 Given its importance, the Biginelli reaction has been the subject of several researches and was carried out in the presence of various catalysts such as Brønsted acids in homogeneous medium as HCl, [28][29][30][31][32] H 2 SO 4, [33][34] para-toluenesulfonic acid, 35 methanesulfonic acid, 36 HBF 4 , 37 b oric acid, 38 phenylboronic acid, 39 formylphenylboronic acid, 40 carboxylic acid, 41 molybdophosphoric acid, 42 trifluoroacetic acid, 43 Lewis acids in homogeneous medium [44][45][46][47] as FeCl 2 , FeCl 3 , NiCl 2 , CoCl 2 , Ce(NO 3 ) 3 , and heterogeneous catalysts as Fe 2 O 3 nanoparticles, 48 Nafion-Ga, Al 2 O 3 , TiO 2 , SiO 2 oxides. [49][50] The Biginelli reaction was also carried out in the presence of montmorillonite of different origins, which has undergone various modifications and treatments. In the works of Singh, ZrO 2 -pillared clay was prepared and used in the Biginelli reaction under thermal and microwave heating.…”