Asymmetric Borane Reduction of Prochiral Ketones Catalyzed by α,α-Disubstituted Aziridinemethanols

Abstract

A series of novel a,a-disubstituted aziridinemethanols have been developed for the enantioselective reduction of ketones in refluxing tetrahydrofuran. The optically active secondary alcohol products were obtained in good enantiomeric excess (*96.8%) and excellent yields. The results showed that the substituent groups on the hydroxyl-bearing carbon of aziridinemethanols obviously affected the enantioselectivity.

Synthesis of a Novel Class of Phosphonoaziridines as Interesting Antibacterial Agents

“…Therefore, an assumption might be made that the presence of an aziridine moiety in natural as well as synthetic compounds structures is essential to the observed activities [11]. As a result, several syntheses are found in the literature and it is beyond the scope of this work to mention all of them [12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”