2023
DOI: 10.1039/d3cs00701d
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Asymmetric catalysis with FLPs

Xiangqing Feng,
Wei Meng,
Haifeng Du

Abstract: This review provides an overview of the important progress in FLP-catalyzed asymmetric reactions made over the past 15 years, and both the merits and limitations of FLP-catalysis have been highlighted.

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Cited by 13 publications
(4 citation statements)
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References 102 publications
(85 reference statements)
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“…[2][3][4][5][6] The initial finding that FLPs have the ability to activate H 2 7 has led to a large number of studies exploring the substrate scope for metal-free FLP reductions and the development of effective metal-free FLP hydrogenation catalysts. 8 In addition, the adaptation of FLP catalysts to asymmetric reductions 9,10 has been demonstrated and continues to evolve. These advances clearly have potential for applications in pharmaceutical synthesis as this methodology avoids catalysts derived metal residues in the products.…”
Section: Introductionmentioning
confidence: 99%
“…[2][3][4][5][6] The initial finding that FLPs have the ability to activate H 2 7 has led to a large number of studies exploring the substrate scope for metal-free FLP reductions and the development of effective metal-free FLP hydrogenation catalysts. 8 In addition, the adaptation of FLP catalysts to asymmetric reductions 9,10 has been demonstrated and continues to evolve. These advances clearly have potential for applications in pharmaceutical synthesis as this methodology avoids catalysts derived metal residues in the products.…”
Section: Introductionmentioning
confidence: 99%
“…4 In relation to donor–acceptor complexation, frustrated Lewis pairs (FLPs) are gaining interest as they contain unquenched sites of Lewis acidity and basicity, leading to advantageous small molecule activation and/or catalysis. 5 Over the past few years, our group has used Bourissou's FLP chelate, i Pr 2 P(C 6 H 4 )BCy 2 (Cy = cyclohexyl), abbreviated here as PB , 6 to isolate adducts of dihydrotetrelenes (EH 2 ; E = Si and Ge). 7,8 Specifically, PB{EH 2 } complexes can release films of amorphous Si and Ge, respectively, upon heating to ca.…”
Section: Introductionmentioning
confidence: 99%
“…[19] In addition, the expanding field of Frustrated Lewis Pair (FLP) chemistry originating from the combination of sterically encumbered chiral Lewis acidic boranes and achiral Lewis bases or vice versa has advanced the chemical landscape of main group enantioselective transformations. [20][21][22][23] Moving down group 13, aluminium has often been employed in enantioselective catalysis using chiral ligands. [24] Commonly, the aluminium centre is embedded in salen complexes to promote reactions such as the enantioselective hydroborations of ketones, [25] carboxycyanations of aldehydes, [26,27] desymmetrisation of mesoepoxides, [28] and hydrocyanations of aldimines.…”
Section: Introductionmentioning
confidence: 99%