Asymmetric Catalytic Phenyl Transfer to Imines: Highly Enantioselective Synthesis of Diarylmethylamines.

Hermanns, Nina; Dahmen, Stefan; Bolm, Carsten; Braese, Stefan

doi:10.1002/chin.200305104

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Directed Evolution Of Monoamine Oxidase From Aspergillus Nig1

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2019

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“…5), motifs that are present in the commercially available drugs Levocetirizine (17) and Solifenacin (18) ( Fig. 5), respectively (Hermanns et al 2002;Nguyen et al 2011). To improve the "toolbox" of MAO-N further to catalyze these bulky amines, the D5 variant of MAO-N was subjected to further directed evolution.…”

Section: Directed Evolution Of Monoamine Oxidase From Aspergillus Nigmentioning

confidence: 99%

Recent progress in directed evolution of stereoselective monoamine oxidases

Duan

Qin

et al. 2019

Bioresour. Bioprocess.

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Monoamine oxidases (MAOs) use molecular dioxygen as oxidant to catalyze the oxidation of amines to imines. This type of enzyme can be employed for the synthesis of primary, secondary, and tertiary amines by an appropriate deracemization protocol. Consequently, MAOs are an attractive class of enzymes in biocatalysis. However, they also have limitations in enzyme-catalyzed processes due to the often-observed narrow substrate scope, low activity, or poor/wrong stereoselectivity. Therefore, directed evolution was introduced to eliminate these obstacles, which is the subject of this review. The main focus is on recent efforts concerning the directed evolution of four MAOs: monoamine oxidase (MAO-N), cyclohexylamine oxidase (CHAO), D-amino acid oxidase (pkDAO), and 6-hydroxy-D-nicotine oxidase (6-HDNO).

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Section: Directed Evolution Of Monoamine Oxidase From Aspergillus Nigmentioning

confidence: 99%