2017
DOI: 10.1007/978-3-319-53150-2_5
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Asymmetric Cell Division in the One-Cell C. elegans Embryo: Multiple Steps to Generate Cell Size Asymmetry

Abstract: The first division of the one-cell C. elegans embryo has been a fundamental model in deciphering the mechanisms underlying asymmetric cell division. Polarization of the one-cell zygote is induced by a signal from the sperm centrosome and results in the asymmetric distribution of PAR proteins. Multiple mechanisms then maintain PAR polarity until the end of the first division. Once asymmetrically localized, PAR proteins control several essential aspects of asymmetric division, including the position of the mitot… Show more

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Cited by 15 publications
(25 citation statements)
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“…In the C. elegans zygote, the sperm entry point acts as a cue inducing an actomyosin flow 16 establishing Par complex polarity at the opposite end of the cell (see ref. 55 for a review). Septins 56 , Cindr, Roughest 39 and Flare 37 can be linked in one way or another to the regulation of actomyosin, and at least the maintenance of Baz localization in mitotic NBs is also actin-dependent 57 .…”
Section: Discussionmentioning
confidence: 99%
“…In the C. elegans zygote, the sperm entry point acts as a cue inducing an actomyosin flow 16 establishing Par complex polarity at the opposite end of the cell (see ref. 55 for a review). Septins 56 , Cindr, Roughest 39 and Flare 37 can be linked in one way or another to the regulation of actomyosin, and at least the maintenance of Baz localization in mitotic NBs is also actin-dependent 57 .…”
Section: Discussionmentioning
confidence: 99%
“…elegans and Drosophila melanogaster , have led to insights into the molecules and mechanisms that distribute developmental potential to the two daughter cells in an ACD. Many of these molecules control not only the distribution of fate but also the orientation of the mitotic spindle, a process that is critical for the appropriate distribution of fate unequally to daughter cells [ 3 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…We find that the cell volume differences along the anterior-posterior axis of the Ciona notochord can be fully explained by relatively subtle patterns of asymmetric division that act iteratively over multiple cell cycles to have a cumulatively important effect on organ shape. These subtle and iterative unequal cleavages that occur without obvious segregation of cell fate appear quite different than the canonical models of asymmetric division, such as Drosophila neuroblasts and C. elegans first cleavage [8,9].…”
Section: Introductionmentioning
confidence: 90%
“…Asymmetric divisions are common in developing embryos, but the canonical models, such as C. elegans first cleavage and fly neuroblasts, all involve highly polarized cells that divide to give daughters of considerably different size and completely different fate [8,9,23,[26][27][28][29]. The asymmetric divisions in the Ciona notochord, however, are relatively subtle and do not involve any obvious segregation of cell identity.…”
Section: Asymmetric Division As a Direct Morphogenetic Mechanismmentioning
confidence: 99%